Current Research and Scholarly Interests
Immune suppression; Immune tolerance; Dendritic cells; Regulatory myeloid cells; T cell immune responses; GVHD; Transplantation; Autoimmune diseases.
1) Understand the plasticity of myeloid cells and T cells in different immune-related diseases, like inflammation, cancer, autoimmune diseases, etc.
2) Understand how immune suppression and immune tolerance are formed in both physiological and pathological settings.
3) To apply the discoveries from the bench to the bedside.
Myeloid cells including DCs, macrophages and MDSCs are my foci, especially their function on different T cell lineage (Th1, Th2, Th17, Treg), or vice versa.
In collaboration with Prof. Samuel Strober, I am also working on a project to understand the role of DCs in the induction of immune tolerance to organ and bone marrow transplants.