Bio

Clinical Focus


  • Neurology
  • Monitoring, Intraoperative
  • Neurophysiology
  • Spasticity
  • Brain Concussion

Academic Appointments


Professional Education


  • Fellowship:Stanford University School of Medicine (2010) CA
  • Residency:Stanford University School of Medicine (2009) CA
  • Board Certification, American Board of Clinical Neurophysiology, Advanced Central Clinical Neurophysiology with Added Competency in Intraoperative Monitoring (2014)
  • Board Certification: Neurology, American Board of Psychiatry and Neurology (2009)
  • Internship:Santa Clara Valley Medical Center (2006) CA
  • Medical Education:Rosalind Franklin University / The Chicago Medical School (2005) IL

Research & Scholarship

Clinical Trials


  • Study to Assess the Efficacy, Safety, Tolerability, and Pharmacokinetics of BIIB033 in Participants With Relapsing Forms of Multiple Sclerosis When Used Concurrently With Avonex Not Recruiting

    The primary objective of the study is to evaluate the efficacy of BIIB033 in participants with active relapsing MS when used concurrently with Avonex. Secondary objectives of this study in this study population are to assess the safety, tolerability, and population PK of BIIB033 when used concurrently with Avonex

    Stanford is currently not accepting patients for this trial.

    View full details

Teaching

2016-17 Courses


Publications

All Publications


  • In Vivo Imaging of Human Sarcomere Twitch Dynamics in Individual Motor Units NEURON Sanchez, G. N., Sinha, S., Liske, H., Chen, X., Viet Nguyen, V., Delp, S. L., Schnitzer, M. J. 2015; 88 (6): 1109-1120

    Abstract

    Motor units comprise a pre-synaptic motor neuron and multiple post-synaptic muscle fibers. Many movement disorders disrupt motor unit contractile dynamics and the structure of sarcomeres, skeletal muscle's contractile units. Despite the motor unit's centrality to neuromuscular physiology, no extant technology can image sarcomere twitch dynamics in live humans. We created a wearable microscope equipped with a microendoscope for minimally invasive observation of sarcomere lengths and contractile dynamics in any major skeletal muscle. By electrically stimulating twitches via the microendoscope and visualizing the sarcomere displacements, we monitored single motor unit contractions in soleus and vastus lateralis muscles of healthy individuals. Control experiments verified that these evoked twitches involved neuromuscular transmission and faithfully reported muscle force generation. In post-stroke patients with spasticity of the biceps brachii, we found involuntary microscopic contractions and sarcomere length abnormalities. The wearable microscope facilitates exploration of many basic and disease-related neuromuscular phenomena never visualized before in live humans. VIDEO ABSTRACT.

    View details for DOI 10.1016/j.neuron.2015.11.022

    View details for Web of Science ID 000368443900008

    View details for PubMedID 26687220

  • Neuromonitoring: EMG, SSEP and MEP Neurosurgery Tricks of the Trade: Spine and Peripheral Nerves Nguyen, V., Lopez, J. R. edited by Nader, R., Berta, S. Thieme. 2014; 1st edition: Chapter 88
  • Peripheral Nerve Surgery A Practical Approach to Neurophysiologic Intraoperative Monitoring Nguyen, V., Jones, E. edited by Husain, A. M. Demos Medical Publishing. 2014; 2nd edition: 163-179
  • Detection of inferolateral trunk syndrome by neuromonitoring during catheter angiography with provocative testing. Journal of neurointerventional surgery Le, S., Dodd, R., L√≥pez, J., Nguyen, V., Cho, S. C., Lee, L. 2013; 5 (2)

    Abstract

    It is not uncommon that endovascular balloon test occlusion (BTO) is performed to assess collateral blood flow and risk of injury of permanent occlusion of the internal carotid artery (ICA). This case is the first reported of detection and reversal of the inferolateral trunk (ILT) syndrome in an awake patient during provocative BTO; prompt recognition of the syndrome effectively prevented permanent neurologic deficits.The case of a 42-year-old woman is reported who had a left sphenoid wing meningioma with extension into the cavernous sinus and who underwent awake catheter angiography with provocative BTO of the ICA. Serial examinations by intraoperative monitoring neurologists and neurointerventionalists detected acute progressive left retro-orbital pressure followed by sudden inability to adduct the left eye, or a left medial rectus palsy, indicative of the ILT syndrome which led to immediate balloon deflation and resolution of the deficits. The hypothesis was that hypoperfusion of the ILT, an arterial branch of the ICA which provides blood supply to several cranial nerves (CN) III, CN V1 and CN V2, caused her acute symptoms.Although cerebral ischemia is a well known complication of endovascular procedures, CN ischemia is a rare potential risk. Knowledge of cerebrovascular anatomy and serial examinations prevented neurologic deficits; this case underscores the added utility of examinations by intraoperative monitoring neurologists and interdisciplinary collaboration.

    View details for DOI 10.1136/neurintsurg-2011-010236

    View details for PubMedID 22345146