Current Research and Scholarly Interests
I conduct and develop clinical research trials in allogeneic and autologous hematopoietic cell transplantation (HCT) for hematologic malignancies: acute myelogenous leukemia (AML), acute lymphocytic leukemia (ALL), chronic myelogenous leukemia (CML), chronic lymphocytic leukemia (CLL), myeloproliferative disease, non-Hodgkin lymphoma (NHL), Hodgkin disease, myelodysplasia and aplastic anemia.
A specific interest is graft versus host disease (GVHD), exploring prevention and treatment of acute and chronic GVHD via clinical trials. The objectives of the GVHD trials are to reduce the incidence of GVHD, successfully treat acute and chronic GVHD, identify modalities or agents with more tolerable toxicity profiles and ultimately improve morbidity and mortality of affected patients. To this end, I have established a chronic GVHD clinic within the Stanford BMT division which aids in prospectively identifiing appropriate patients for clinical trials. The chronic GVHD clinic allows comprehensive evaluation and treatment for allogeneic BMT patients with new or progressive CGVHD. Through a multidisciplinary approach with my interested colleagues, I hope to impact the formidable effects GVHD has on the quality of life of the post-allogeneic transplant patient.
Other interests include unrelated donor HCT exploring alternate preparative regimens or graft sources as well as HLA typing.