Current Research and Scholarly Interests
We are investigating the use of focused ultrasound for neuromodulation of the brain for direct stimulation and inhibition of the brain for preclinical mapping of brain function, reduction of epileptic seizures, and for general study of the brain. We are using focused ultrasound to open the blood brain barrier in order to enhance drug delivery to cancers of the brain. We are also using focused ultrasound to thermally ablate tissue for movement disorders such as essential tremor, as well as for cancers in the body.
In addition to the basic science study of neuromodulation and cancer treatment, we are also engineering key MRI methods that enable monitoring these interventions, include MR thermometry, MR-acoustic radiation force imaging, and phase aberration correction using a combined approach of simulation and ultrashort echo time MRI imaging of bone.