Current Research and Scholarly Interests
Our research program focuses on the mechanisms that control the proliferation of mammalian cells under normal and pathological conditions (regeneration, cancer), with a particular emphasis on stem cells and gene regulatory networks. We combine genetic, genomics, and proteomics approaches to identify and investigate genes and pathways involved in cancer initiation and progression. We use genome-editing strategies to develop and study genetically-engineered mouse models for human cancers, including lung cancer, pancreatic cancer, and liver cancer. Our work spans the investigation of fundamental biological processes to the implementation of clinical trials based on our findings in pre-clinical models.