School of Medicine
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Alexander Eckehart Urban
Assistant Professor of Psychiatry and Behavioral Sciences (Major Laboratories and Clinical Translational Neurosciences Incubator) and of Genetics
Current Research and Scholarly Interests Complex behavioral and neuropsychiatric phenotypes often have a strong genetic component. This genetic component is often extremely complex and difficult to dissect. The current revolution in genome technology means that we can avail ourselves to tools that make it possible for the first time to begin understanding the complex genetic and epigenetic interactions at the basis of the human mind.
Professor of Medicine (Immunology and Rheumatology)
Current Research and Scholarly Interests The long-term research goal of Dr. Utzs laboratory is (1) to develop a better understanding of the pathogenic mechanisms underlying systemic lupus erythematosus (SLE) and other autoimmune diseases by exploring signaling pathways that are activated during apoptosis; and (2) to better understand the complicated process of programmed cell death.
Postdoctoral Research fellow, SCRDP/ Heart Disease Prevention
Current Research and Scholarly Interests My main research interests are on the effect of social mobility and social policies on health inequalities. My dissertation work focused on the effect of the Korean War GI Bill on mental health; I showed that eligibility for the Korean War GI Bill reduced socio-economic disparities in depression markers among veterans, but found no evidence of a spillover to veteran wives. We also found that GI Bill eligibility is associated with improved lung function for veterans from socially vulnerable backgrounds, but not for the socially advantaged. I am working on two papers studying the impact of lifecourse social mobility on inequalities in biologic and physical markers of health; we found that the upwardly mobile have similar health to those with consistently high socio-economic status, while the downwardly mobile retain few benefits from their early-life advantage. These studies indicate that health and health inequalities are mutable across the lifecourse. In future work, I will examine the effect of the Vietnam War GI Bill and compulsory schooling laws on socio-economic and racial disparities in smoking behaviors and smoking-related morbidity.
In order to explore health inequalities as rigorously as possible, I have lead several methodological analyses. In one paper, we compared different matching methods (propensity score matching, PSM, and coarsened exact matching, CEM) for making causal inference from observational data, and found that CEM drastically out-performs PSM in balancing the multivariate distribution of matching covariates. We are now in the process of conducting a simulation analysis to determine how PSM and CEM perform under different common support and confounding scenarios. In other methodological work, we used factor analysis to create scales that measure childhood human, financial, and social capital; we psychometrically validate these markers, and compared them to other comprehensive operationalizations for quality of predictions. We found the validated measures out-performed other operationalizations, increasing statistical power and reducing bias. Through these studies, I show tangible ways to improve the quality of health research.
Randall Vagelos, MD
Professor of Medicine (Cardiovascular) at the Stanford University Medical Center
Current Research and Scholarly Interests I. Congestive Heart Failure New Medical Therapies Prognostic Evaluation Selection for Cardiac Transplantation II. Screening for Myocardial Necrosis New ECG Monitoring Devices New Serum Markers III. Screening for CAD Patients Who Have Received Radiation Rx Diabetics Being Considered for Renal Transplantation
IV. Advanced coronary and valvular disease, evaluationg candidacy for high risk interventions.
Yona Vaisbuch MD
Clinical Instructor, Otolaryngology (Head and Neck Surgery)
Current Research and Scholarly Interests Translational Medicine, Robotics, EHealth, Middle and Inner ear Mechanics
Professor of Medicine (Cardiovascular) at SUMC
Current Research and Scholarly Interests My lab is focused on understanding the mechanism mediating acute and chronic allograft failure, in particular on the role of microvascular injury in acute allograft failure and the mechanisms of mediating transplant coronary artery disease. 1. Role of microvascular injury in acute allograft failure.