School of Medicine
Showing 1-100 of 221 Results
Russ B. Altman
Kenneth Fong Professor and Professor of Bioengineering, of Genetics, of Medicine (General Medical Discipline), of Biomedical Data Science and, by courtesy, of Computer Science
Current Research and Scholarly Interests I refer you to my web page for detailed list of interests, projects and publications. In addition to pressing the link here, you can search "Russ Altman" on http://www.google.com/
Cristina M. Alvira
Assistant Professor of Pediatrics (Critical Care)
Current Research and Scholarly Interests The overall objective of the Alvira Laboratory is to elucidate the mechanisms that promote postnatal lung development and repair, by focusing on three main scientific goals: (i) identification of the signaling pathways that direct the transition between the saccular and alveolar stages of lung development; (ii) exploration of the interplay between postnatal vascular and alveolar development; and (iii) determination of developmentally regulated pathways that mediate lung repair after injury.
Professor of Neurology at the Stanford University Medical Center
Current Research and Scholarly Interests Our research focuses on the investigation of the brain’s innate immune response, and the role that maladaptive microglial activity plays in initiation and progression of neurological disease.
Timothy Angelotti MD, PhD
Associate Professor of Anesthesiology, Perioperative and Pain Medicine (ICU) at the Stanford University Medical Center
Current Research and Scholarly Interests My research efforts are focused on investigating the pharmacological and physiological interface of the autonomic nervous system with effector organs. Utilizing molecular, cellular, and electrophysiological techniques, we are examining alpha2 adrenergic receptor function in cultured sympathetic neurons. Future research aims will be directed toward understanding neurotransmitter release in general.
Euan A. Ashley
Associate Professor of Medicine (Cardiovascular), of Genetics, of Biomedical Data Science and, by courtesy, of Pathology at the Stanford University Medical Center
Current Research and Scholarly Interests The Ashley lab is focused on precision medicine. We develop methods for the interpretation of whole genome sequencing data to improve diagnosis of genetic disease and to personalize the practice of medicine. We also use network approaches to characterize biology. The wet bench is where we take advantage of cell systems, transgenic models and microsurgical models of disease to prove causality of our favorite targets.
Themistocles L. Assimes, MD PhD
Assistant Professor of Medicine (Cardiovascular Medicine)
Current Research and Scholarly Interests Genetic Epidemiology, Genetic Determinants of Complex Traits related to Cardiovasular Medicine, Coronary Artery Disease related pathway analyses and integrative genomics, Mendelian randomization studies, risk prediction for major adverse cardiovascular events, cardiovascular medicine related pharmacogenomics, ethnic differences in the determinants of Insulin Mediated Glucose Uptake, pharmacoepidemiology of cardiovascular drugs & outcomes
Leah Backhus MD MPH FACS
Associate Professor of Cardiothoracic Surgery (Thoracic Surgery) at the Palo Alto Veterans Affairs Health Care System
Bio Leah Backhus trained in general surgery at the University of Southern California and cardiothoracic surgery at the University of California Los Angeles. She practices at Stanford Hospital and is Chief of Thoracic Surgery at the VA Palo Alto. Her surgical practice consists of general thoracic surgery with special emphasis on thoracic oncology and minimally invasive surgical techniques. She is also involved in research with the Thoracic Surgical Health Services Research group, and has grant funding through the Veterans Affairs Administration. Her current research interests are in imaging surveillance following treatment for lung cancer and cancer survivorship. She serves as a professional member of the Patient Centered Outcomes Research Institute (PCORI) Advisory Panel on Improving Healthcare Systems. She is Thoracic Track Residency Associate Program Director and serves on the ACGME Residency Review Committee for Thoracic Surgery.
The Ernest and Amelia Gallo Professor in the School of Medicine and Professor of Developmental Biology
Current Research and Scholarly Interests Function of Hedgehog proteins and other extracellular signals in morphogenesis (pattern formation), in injury repair and regeneration (pattern maintenance). We study how the distribution of such signals is regulated in tissues, how cells perceive and respond to distinct concentrations of signals, and how such signaling pathways arose in evolution. We also study the normal roles of such signals in stem-cell physiology and their abnormal roles in the formation and expansion of cancer stem cells.
Professor of Radiology (General Radiology) at the Stanford University Medical Center
Current Research and Scholarly Interests Myocardial bridges (MB) with associated upfront atherosclerotic lesions are common findings on coronary computed tomography angiography (CTA). Abnormal septal wall motion in exercise echocardiography (EE) may to be associated with MB. Intravascular ultrasound (IVUS) is considered the gold standard for the detection of MB. We investigate whether CTA is comparable to IVUS for the assessment of MB and upstream plaques in symptomatic patients with suspicion for MB raised by EE.
Alfred Woodley Salter and Mabel Smith Salter Endowed Professor in Pediatrics
Current Research and Scholarly Interests 1. Role of the G protein coupled receptors in regulating mitochondrial structure and function.
2. Differences between R and L ventricular responses to stress, including gene expression and miR regulation.
3. Using iPSC-derived myocytes to understand heart failure and congenital heart disease.
4. Tools for evaluation of cardiac physiology in transgenic mice and isolated cardiomyocytes.
5. Anti-body mediated rejection.
6. Biomarkers for post-transplant lymphoproliferative disorder.
Professor of Pathology at the Stanford University Medical Center
Current Research and Scholarly Interests Cardiopulmonary and pulmonary transplant medicine; diagnostic surgical pathology
Vivek Bhalla, MD, FASN
Assistant Professor of Medicine (Nephrology) at the Stanford University Medical Center
Current Research and Scholarly Interests Dr. Bhalla's research interests are in the pathogenesis of diabetic kidney disease and salt-sensitive hypertension. The laboratory is interested in elucidating regulators of inflammation in diabetic glomeruli. We interface these studies with collaborative projects on biomarkers for human diabetic nephropathy. We also study the mechanisms of aberrant sodium handling in the setting of obesity and insulin resistance. We use molecular and transgenic approaches to address our research questions.
Sandip Biswal, MD
Associate Professor of Radiology (General Radiology) at the Stanford University Medical Center
Current Research and Scholarly Interests Chronic pain sufferers are unfortunately limited by poor diagnostic tests and therapies. Our research group is interested in 'imaging pain' by using multimodality molecular imaging techniques to study peripheral nociception and inflammation with the goal of accurately identifying pain generators. We are developing new approaches with positron emission tomography (PET) and magnetic resonance imaging (MRI) (PET/MRI) and are currently in clinical trials.
Professor (Research) of Pediatrics (Neonatology)
Current Research and Scholarly Interests Our research focuses on the pathogenesis and treatment of acute and chronic neonatal lung injury and the mechanisms that regulate lung fluid balance and alveolar & pulmonary vascular development after premature birth.
Helen M. Blau
The Donald E. and Delia B. Baxter Foundation Professor and Director, Baxter Laboratory for Stem Cell Biology
Current Research and Scholarly Interests Prof. Helen Blau's research area is regenerative medicine with a focus on stem cells. Her research on nuclear reprogramming and demonstrating the plasticity of cell fate using cell fusion is well known and her laboratory has also pioneered the design of biomaterials to mimic the in vivo microenvironment and direct stem cell fate. Current findings are leading to more efficient iPS generation, cell based therapies by dedifferentiation a la newts, and discovery of novel molecules and therapies.
Michele and Timothy Barakett Endowed Professor
Current Research and Scholarly Interests Our lab studies the molecular basis of longevity. We are interested in the mechanism of action of known longevity genes, including FOXO and SIRT, in the mammalian nervous system. We are particularly interested in the role of these longevity genes in neural stem cells. We are also discovering novel genes and processes involved in aging using two short-lived model systems, the invertebrate C. elegans and an extremely short-lived vertebrate, the African killifish N. furzeri.
Professor of Biomedical Data Science, of Genetics and, by courtesy, of Biology
Current Research and Scholarly Interests My research focuses on analyzing genome wide patterns of variation within and between species to address fundamental questions in biology, anthropology, and medicine. My group works on a variety of organisms and model systems ranging from humans and other primates to domesticated plant and animals. Much of our research is at the interface of computational biology, mathematical genetics, and evolutionary genomics.
Steven D. Chang, MD
Robert C. and Jeannette Powell Neurosciences Professor and, by courtesy, of Otolaryngology-Head and Neck Surgery
Current Research and Scholarly Interests Clinical research includes studies in the treatment of cerebrovascular disorders, such as aneurysms and AVMs, as well as the use of radiosurgery to treat tumors and vascular malformations of the brain and spine.
Dr. Chang is C0-Director of the Cyberknife Radiosurgery Program.
Dr. Chang is also the head of the The Stanford Neuromolecular Innovation Program with the goal of developing new technologies to improve the diagnosis and treatment of patients affected by neurological conditions.
Tara I. Chang, MD, MS, FASN
Assistant Professor of Medicine (Nephrology) at the Stanford University Medical Center
Current Research and Scholarly Interests My research focuses on issues such as blood pressure control, coronary revascularization, and the comparative effectiveness of cardioprotective medications in patients with chronic kidney disease, with the long-term goal of improving cardiovascular outcomes in these high-risk patients.
Jennifer R. Cochran
Associate Professor of Bioengineering and, by courtesy, of Chemical Engineering
Current Research and Scholarly Interests Molecular Bioengineering, Protein Biochemistry, Biotechnology, Cell and Tissue Engineering, Molecular Imaging, Chemical Biology
Andrew J. Connolly, MD/PhD
Associate Professor of Pathology at the Stanford University Medical Center
Current Research and Scholarly Interests Cardiovascular pathology using patient material and animal models
Associate Professor of Pediatrics (Pulmonary Medicine) at Lucile Salter Packard Children's Hospital
Current Research and Scholarly Interests I am interested in studying the effects of inflammation in the lung, in particular, how N-acetylcysteine may affect and decrease that in CF patients. I am the PI of a multi-center study researching this question. Additionally, in a separate study involving children who have received lung transplants, I am a participating site in an NIH-sponsored observational and mechanistic multi-center study that will examine the role of viral infections in causing chronic graft rejection.
Department of Pathology Professor in Experimental Pathology and Professor of Developmental Biology
Current Research and Scholarly Interests Chromatin regulation and its roles in human cancer and the development of the nervous system. Engineering new methods for studying and controlling chromatin in living cells.
Martha S. Cyert
Professor of Biology
Current Research and Scholarly Interests The Cyert lab is identifying signaling networks for calcineurin, the conserved Ca2+/calmodulin-dependent phosphatase, and target of immunosuppressants FK506 and cyclosporin A, in yeast and mammals. Cell biological investigations of target dephosphorylation reveal calcineurin’s many physiological functions. Roles for short linear peptide motifs, or SLiMs, in substrate recognition, network evolution, and regulation of calcineurin activity are being studied.
The J.G. Jackson and C.J. Wood Professor in Chemistry
Bio Professor Dai’s research spans chemistry, physics, and materials and biomedical sciences, leading to materials with properties useful in electronics, energy storage and biomedicine. Recent developments include near-infrared-II fluorescence imaging, ultra-sensitive diagnostic assays, a fast-charging aluminum battery and inexpensive electrocatalysts that split water into oxygen and hydrogen fuels.
Born in 1966 in Shaoyang, China, Hongjie Dai began his formal studies in physics at Tsinghua U. in Beijing (B.S. 1989) and applied sciences at Columbia U. (M.S. 1991). His doctoral work under Dr. Charles Lieber at Harvard U. (Ph.D. 1994) focused on charge-density waves and superconductivity. During postdoctoral research at Rice U. with Dr. Richard Smalley, he developed carbon nanotube probes for atomic force microscopy. He joined the Stanford faculty in 1997, and in 2007 was named Jackson–Wood Professor of Chemistry. Among many awards, he has been recognized with the ACS Pure Chemistry Award, APS McGroddy Prize for New Materials, Julius Springer Prize for Applied Physics and Materials Research Society Mid-Career Award. He has been elected to the American Academy of Arts and Sciences, AAAS and National Academy of Sciences.
The Dai Laboratory has advanced the synthesis and basic understanding of carbon nanomaterials and applications in nanoelectronics, nanomedicine, energy storage and electrocatalysis.
The Dai Lab pioneered some of the now-widespread uses of chemical vapor deposition for carbon nanotube (CNT) growth, including vertically aligned nanotubes and patterned growth of single-walled CNTs on wafer substrates, facilitating fundamental studies of their intrinsic properties. The group developed the synthesis of graphene nanoribbons, and of nanocrystals and nanoparticles on CNTs and graphene with controlled degrees of oxidation, producing a class of strongly coupled hybrid materials with advanced properties for electrochemistry, electrocatalysis and photocatalysis. The lab’s synthesis of a novel plasmonic gold film has enhanced near-infrared fluorescence up to 100-fold, enabling ultra-sensitive assays of disease biomarkers.
Nanoscale Physics and Electronics
High quality nanotubes from his group’s synthesis are widely used to investigate the electrical, mechanical, optical, electro-mechanical and thermal properties of quasi-one-dimensional systems. Lab members have studied ballistic electron transport in nanotubes and demonstrated nanotube-based nanosensors, Pd ohmic contacts and ballistic field effect transistors with integrated high-kappa dielectrics.
Nanomedicine and NIR-II Imaging
Advancing biological research with CNTs and nano-graphene, group members have developed π–π stacking non-covalent functionalization chemistry, molecular cellular delivery (drugs, proteins and siRNA), in vivo anti-cancer drug delivery and in vivo photothermal ablation of cancer. Using nanotubes as novel contrast agents, lab collaborations have developed in vitro and in vivo Raman, photoacoustic and fluorescence imaging. Lab members have exploited the physics of reduced light scattering in the near-infrared-II (1000-1700nm) window and pioneered NIR-II fluorescence imaging to increase tissue penetration depth in vivo. Video-rate NIR-II imaging can measure blood flow in single vessels in real time. The lab has developed novel NIR-II fluorescence agents, including CNTs, quantum dots, conjugated polymers and small organic dyes with promise for clinical translation.
Electrocatalysis and Batteries
The Dai group’s nanocarbon–inorganic particle hybrid materials have opened new directions in energy research. Advances include electrocatalysts for oxygen reduction and water splitting catalysts including NiFe layered-double-hydroxide for oxygen evolution. Recently, the group also demonstrated an aluminum ion battery with graphite cathodes and ionic liquid electrolytes, a substantial breakthrough in battery science.
Michael D. Dake
Thelma and Henry Doelger Professor of Cardiovascular Surgery
Current Research and Scholarly Interests Improved endovascular procedures and devices to treat aortic lesions, peripheral arterial disease and venous abnormalities. Focused interest in drug-eluting stents and balloons, endovascular stent-grafts, including branched aortic devices and techniques for the endovascular management of aortic dissection. Current clinical research projects include drug-eluting stents for superficial femoral arterial disease and multiple device trials to evaluate stent-grafts for the treatment of aortic lesions.
Ronald L. Dalman MD
Walter Clifford Chidester and Elsa Rooney Chidester Professor of Surgery
Current Research and Scholarly Interests Vascular biology, arterial remodeling, aneurysm development; innovative treatment strategies for AAA, animal models of arterial disease, arterial remodeling and flow changes in spinal cord injury, genetic regulation of arterial aneurysm formation
Rajesh Dash, MD, PhD, Medical & Scientific Director, SSATHI
Assistant Professor of Medicine (Cardiovascular Medicine) at the Stanford University Medical Center
Current Research and Scholarly Interests My research focuses on imaging cell signaling in the heart. I am developing molecular imaging probes that track to injured heart tissue, such that non-invasive imaging techniques, like cardiac MRI, can visualize these probe signals in real-time. The translational goal of my research is to develop new ways to detect early cardiac injury before permanent damage occurs, so that preventive medical therapy can be started.
Mark M. Davis
The Burt and Marion Avery Family Professor
Current Research and Scholarly Interests Molecular mechanisms of lymphocyte recognition and differentiation; Systems immunology and human immunology; vaccination and infection.
Vinicio de Jesus Perez MD
Assistant Professor of Medicine (Pulmonary and Critical Care Medicine)
Current Research and Scholarly Interests My work is aimed at understanding the molecular mechanisms involved in the development and progression of pulmonary arterial hypertension (PAH). I am interested in understanding the role that the BMP and Wnt pathways play in regulating functions of pulmonary endothelial and smooth muscle cells both in health and disease.
Gundeep Dhillon, MD, MPH
Associate Professor of Medicine (Pulmonary and Critical Care Medicine) at the Stanford University Medical Center
Current Research and Scholarly Interests 1. Use of an administrative database (UNOS) to study lung transplant outcomes.
2. Expression of the plasminogen activator inhibitor (PAI) 1 antibody in peripheral blood after lung transplantation and its association with bronchiolitis obliterans syndrome (chronic rejection).
3. Impact of airway hypoxia, due to lack of bronchial circulation, on long-term lung transplant outcomes.
4. CMV specific T-cell immunity in lung transplant recipients and its impact on acute rejection.
Professor of Pediatrics (Pediatric Cardiology) at the Lucile Salter Packard Children's Hospital
Current Research and Scholarly Interests Arrhythmia management in pediatric heart failure, especially resynchronization therapy in congenital heart disease,Radio frequency catheter ablation of pediatric arrhythmias,
Associate Professor of Chemical Engineering
Current Research and Scholarly Interests My lab is deeply interested in understand how living cells sense and respond to mechanical stimuli.
Assistant Professor of Chemical and Systems Biology
Current Research and Scholarly Interests Developing new mass spectrometry-based experimental and computational tools that advance the field of proteomics, and applying them to a variety of important biomedical paradigms, including antigen presentation in cancer, and monitoring host responses to the gut microbiome.
Professor of Cardiothoracic Surgery (Adult Cardiac Surgery) at the Stanford University Medical Center
Current Research and Scholarly Interests Cardiac surgery education and simulation-based learning, coronary artery bypass surgery, cardiac valve disease, thoracic aortic disease
William Fearon, MD
Professor of Medicine (Cardiovascular Medicine) at the Stanford University Medical Center
Current Research and Scholarly Interests Dr. Fearon's general research interest is coronary physiology. In particular, he is investigating invasive methods for evaluating the coronary microcirculation. His research is currently funded by an NIH R01 Award.
Jeffrey A. Feinstein, MD, MPH
Dunlevie Family Professor of Pulmonary Vascular Disease and Professor, by courts, of Bioengineering at the Lucile Salter Packard Children's Hospital
Current Research and Scholarly Interests Research interests include (1) computer simulation and modeling of cardiovascular physiology with specific attention paid to congenital heart disease and its treatment, (2) the evaluation and treatment of pulmonary hypertension/pulmonary vascular diseases, and (3) development and testing of medical devices/therapies for the treatment of congenital heart disease and pulmonary vascular diseases.
Assistant Professor of Pediatrics (Endocrinology)
Current Research and Scholarly Interests The overall goal of our research is to understand on both a molecular and systemic level how hormones regulate stem cell fate decisions and the role these pathways play in both physiology and disease. We use molecular biology and in vivo models to elucidate mechanisms of regulating cell fate determination by the endocrine system. Understanding these processes has profound and broad implications for both science and health.
Associate Professor of Cardiothoracic Surgery (Adult Cardiac Surgery) at the Stanford University Medical Center
Current Research and Scholarly Interests Molecular and genetic mechanisms of aortic aneurysm/dissection development. Molecular mechanisms of aneurysm formation in Marfan Syndrome. Clinical research interests include thoracic aortic diseases (aneurysms, dissections).
Professor of Radiology (General Radiology) at the Stanford University Medical Center
Current Research and Scholarly Interests Non-invasive Cardiovascular Imaging
Contrast Medium Dynamics
Michael B. Fowler, MB, FRCP
Professor of Medicine (Cardiovascular) at the Stanford University Medical Center
Current Research and Scholarly Interests Adrenergic nervous system; beta-adrenergic function in, heart failure; drugs in heart failure.
W. M. Keck, Sr. Professor in Engineering and Professor, by court, of Materials Science and Engineering and of Chemistry
Bio The properties of ultrathin polymer films are often different from their bulk counterparts. We use spin casting, Langmuir-Blodgett deposition, and surface grafting to fabricate ultrathin films in the range of 100 to 1000 Angstroms thick. Macromolecular amphiphiles are examined at the air-water interface by surface pressure, Brewster angle microscopy, and interfacial shear measurements and on solid substrates by atomic force microscopy, FTIR, and ellipsometry. A vapor-deposition-polymerization process has been developed for covalent grafting of poly(amino acids) from solid substrates. FTIR measurements permit study of secondary structures (right and left-handed alpha helices, parallel and anti-parallel beta sheets) as a function of temperature and environment.
A broadly interdisciplinary collaboration has been established with the Department of Ophthalmology in the Stanford School of Medicine. We have designed and synthesized a fully interpenetrating network of two different hydrogel materials that have properties consistent with application as a substitute for the human cornea: high water swellability up to 85%,tensile strength comparable to the cornea, high glucose permeability comparable to the cornea, and sufficient tear strength to permit suturing. We have developed a technique for surface modification with adhesion peptides that allows binding of collagen and subsequent growth of epithelial cells. Broad questions on the relationships among molecular structure, processing protocol, and biomedical device application are being pursued.
Fletcher Jones II Professor in the School of Engineering
Bio The processing of complex liquids (polymers, suspensions, emulsions, biological fluids) alters their microstructure through orientation and deformation of their constitutive elements. In the case of polymeric liquids, it is of interest to obtain in situ measurements of segmental orientation and optical methods have proven to be an excellent means of acquiring this information. Research in our laboratory has resulted in a number of techniques in optical rheometry such as high-speed polarimetry (birefringence and dichroism) and various microscopy methods (fluorescence, phase contrast, and atomic force microscopy).
Another application of orientation dynamics is in the development of solar cells. The efficiency of second-generation solar cells fabricated with conjugated polymers is limited by photoelectron transport within the polymer film. Inspired by electrorheological fluids, an external electric field is applied to the film to induce anisotropy in polymer crystallites, which is expected to enhance electron mobility.
The microstructure of polymeric and other complex materials also cause them to have interesting physical properties and respond to different flow conditions in unusual manners. In our laboratory, we are equipped with instruments that are able to characterize these materials such as shear rheometer, capillary break up extensional rheometer, and 2D extensional rheometer. Then, the response of these materials to different flow conditions can be visualized and analyzed in detail using high speed imaging devices at up to 2,000 frames per second.
There are numerous processes encountered in nature and industry where the deformation of fluid-fluid interfaces is of central importance. Examples from nature include deformation of the red blood cell in small capillaries, cell division and structure and composition of the tear film. Industrial applications include the processing of emulsions and foams, and the atomization of droplets in ink-jet printing. In our laboratory, fundamental research is in progress to understand the orientation and deformation of monolayers at the molecular level. These experiments employ state of the art optical methods such as polarization modulated dichroism, fluorescence microscopy, and Brewster angle microscopy to obtain in situ measurements of polymer films and small molecule amphiphile monolayers subject to flow. Langmuir troughs are used as the experimental platform so that the thermodynamic state of the monolayers can be systematically controlled. For the first time, well characterized, homogeneous surface flows have been developed, and real time measurements of molecular and microdomain orientation have been obtained. These microstructural experiments are complemented by measurements of the macroscopic, mechanical properties of the films.
Margaret T. Fuller
Reed-Hodgson Professor in Human Biology and Professor of Genetics and of Obstetrics/Gynecology (Reproductive and Stem Cell Biology)
Current Research and Scholarly Interests Regulation of stem cell division and self-renewal Cell type specific transcription machinery and regulation of cell differentiation Developmental regulation of cell cycle progression during male meiosis Molecular dissection of the mechanism of cytokinesis.
Sanjiv Sam Gambhir, MD, PhD
Virginia and D.K. Ludwig Professor for Clinical Investigation in Cancer Research and Professor, by courtesy, of Bioengineering and of Materials Science and Engineering
Current Research and Scholarly Interests My laboratory focuses on merging advances in molecular biology with those in biomedical imaging to advance the field of molecular imaging. Imaging for the purpose of better understanding cancer biology and applications in gene and cell therapy, as well as immunotherapy are all being studied. A key long-term focus is the earlier detection of cancer by combining in vitro diagnostics and molecular imaging.
Professor (Research) of Medicine (Stanford Prevention Research Center)
Current Research and Scholarly Interests The role of nutrition in individual and societal health, with particular interests in: plant-based diets, differential response to low-carb vs. low-fat weight loss diets by insulin resistance status, chronic disease prevention, randomized controlled trials, human nutrition, community based studies, Community Based Participatory Research, sustainable food movement (animal rights and welfare, global warming, human labor practices), stealth health, nutrition policy, nutrition guidelines
John Giacomini, MD
Professor of Medicine (Cardiovascular Medicine) at the Palo Alto Veterans Affairs Health Care System
Current Research and Scholarly Interests Calcium channel blockers; membrane pharmacology;, coronary physiology; antiarrhythmic drugs; cardiac hemodynamics;, cellular mechanisms of myocyte hypertrophy.
Mary Kane Goldstein
Professor of Medicine (Center for Primary Care and Outcomes Research) and, by courtesy, of Health Research and Policy at the Palo Alto Veterans Affairs Health Care System
Current Research and Scholarly Interests Health services research in primary care and geriatrics: developing, implementing, and evaluating methods for clinical quality improvement. Current work includes applying health information technology to quality improvement through clinical decision support (CDS) integrated with electronic health records; encoding clinical knowledge into computable formats in automated knowledge bases; natural language processing of free text in electronic health records; analyzing multiple comorbidities
Professor of Psychology
Current Research and Scholarly Interests I am interested in emotion and emotion regulation. My research employs behavioral, physiological, and brain measures to examine emotion-related personality processes and individual differences. My current interests include emotion coherence, specific emotion regulation strategies (reappraisal, suppression), automatic emotion regulation, and social anxiety.
Johnson & Johnson Professor of Surgery and Professor, by courtesy, of Bioengineering and of Materials Science and Engineering
Current Research and Scholarly Interests Geoffrey Gurtner's Lab is interested in understanding the mecahnism of new blood vessel growth following injury and how pathways of tissue regeneration and fibrosis interact in wound healing.
Lawrence Crowley, M.D., Endowed Professor in Child Health
Current Research and Scholarly Interests His research and clinical work focuses on the development of interventional techniques for fetal and neonatal treatment of congenital heart disease, pulmonary, vascular physiology, and the neurologic impact of open-heart surgery. He developed and pioneered the unifocalization procedure, in which a single procedure is used to repair a complex and life-threatening congenital heart defect rather than several staged open-heart surgeries as performed by other surgeons.
Arthur L. Bloomfield Professor of Medicine
Bio Dr. Robert A. Harrington is an interventional cardiologist and the Arthur L. Bloomfield Professor of Medicine and Chairman of the Department of Medicine at Stanford University. Dr. Harrington was previously the Richard Sean Stack, MD Distinguished Professor and the Director of the Duke Clinical Research Institute (DCRI) at Duke University. His research interests include evaluating antithrombotic therapies to treat acute ischemic heart disease and to minimize the acute complications of percutaneous coronary procedures, studying the mechanism of disease of the acute coronary syndromes, understanding the issue of risk stratification in the care of patients with acute ischemic coronary syndromes, building local, national and international collaborations for the efficient conduct of innovative clinical research and trying to better understand and improve upon the methodology of clinical research. His research has been extensively funded through NIH, NIA, other peer reviewed agencies and private industry. Committed to training and mentorship, Harrington has served as the principal mentor for more than 20 post-doctoral clinical research fellows focused on cardiovascular research.
He has authored more than 520 peer-reviewed manuscripts, reviews, book chapters, and editorials. Thomson Reuters lists him as one of the most cited investigators in clinical medicine from 2002-2014. He is a deputy editor of JAMA Cardiology and an editorial board member for the Journal of the American College of Cardiology. He has served as editor of five textbooks and is a senior editor of the 13th and 14th editions of Hurst’s The Heart, one of the leading textbooks of cardiovascular medicine. He has been a member of the NHLBI’s Clinical Trials Study Section and the IOM’s Working Group on Data Sharing. He served as a member of the NIH NCATS Advisory Council Working Group on the IOM CTSA Program. He is currently serving a second term as a member and the chair of the US Food and Drug Administration Cardiovascular and Renal Drugs Advisory Committee.
Harrington was recently a member of the American College of Cardiology (ACC) Board of Trustees and is currently a member of the American Heart Association’s (AHA) Board of Directors and its Science Advisory and Coordinating Committee and served as the Chair for the AHA’s Scientific Sessions in 2013 and 2014. Harrington is a Fellow of the American College of Cardiology, the American Heart Association, the Society for Cardiac Angiography and Intervention, the European Society of Cardiology, the American College of Chest Physicians and the American College of Physicians. He is an elected member of the Association of American Physicians and the Association of University Cardiologists. In 2015, he was elected to membership in the National Academy of Medicine/Institute of Medicine. In 2016, he was named a Master of the American College of Cardiology.
Harrington received his BA in English at the College of the Holy Cross, Worcester, MA. He attended Dartmouth Medical School and received his MD from Tufts University School of Medicine, Boston MA. He did his internship, residency and served as the chief resident in internal medicine at the University of Massachusetts Medical Center, Worcester MA. He trained in cardiology, interventional cardiology and clinical research (Duke Databank for Cardiovascular Disease) at Duke University Medical Center, Durham NC where he was a faculty member from 1993-2012 before joining the Stanford University faculty in 2012. Interested in innovative learning tools, including novel methods of communicating scientific information, Harrington hosts a regular podcast on theheart.org, The Bob Harrington Show, and can be followed on Twitter @HeartBobH.
Paul Heidenreich, MD
Professor of Medicine (Cardiovascular) and, by courtesy, of Health Research and Policy at the Palo Alto Veterans Affairs Health Care System
Current Research and Scholarly Interests My research interests include
1) The cost-effectiveness of new cardiovascular technologies.
Example: tests to screen asymptomatic patients for left ventricular systolic dysfunction.
2) Interventions to improve the quality of care of patients with heart disease. Examples: include clinical reminders and home monitoring.
3) Outcomes research using existing clinical and administrative datasets.
4) Use of echocardiography to predict prognosis (e.g. diastolic dysfunction).
Associate Professor of Materials Science and Engineering and, by courtesy, of Chemical Engineering and of Bioengineering
Current Research and Scholarly Interests Protein engineering
H Craig Heller
Lorry I. Lokey/Business Wire Professor
Current Research and Scholarly Interests Neurobiology of sleep, circadian rhythms, regulation of body temperature, mammalian hibernation, and human exercise physiology. Currently applying background in sleep and circadian neurobiology the understanding and correcting the learning disability of Down Syndrome.
Mark Hlatky, MD
Professor of Health Research and Policy (Health Services Research) and of Medicine (Cardiovascular Medicine)
Current Research and Scholarly Interests My main research work is in "outcomes research", especially examining the field of cardiovascular medicine. Particular areas of interest are the integration of economic and quality of life data into randomized clinical trials, evidence-based medicine, decision models, and cost-effectiveness analysis. I am also interested in the application of novel genetic, biomarker, and imaging tests to assess risk and guide clinical management of coronary artery disease.
Assistant Professor of Cardiothoracic Surgery (Adult Cardiac Surgery)
Current Research and Scholarly Interests Dr. Huangs laboratory aims to understand the chemical and mechanical interactions between extracellular matrix (ECM) proteins and pluripotent stem cells that regulate vascular and myogenic differentiation. The fundamental insights of cell-matrix interactions are applied towards stem cell-based therapies with respect to improving cell survival and regenerative capacity, as well as engineered vascularized tissues for therapeutic implantation.
Professor of Medicine (Cardiovascular Medicine)
Current Research and Scholarly Interests I am interested in the link between metabolic disturbances, such as obesity and insulin resistance, and the development of cardiovascular disease. My research is translational and interdisciplinary, combining methods from the molecular epidemiology field with in vivo and in vitro work to reach new insights into the pathophysiology of cardiovascular disease and related conditions, identification of new biomarkers for improved risk prediction, and discovery of novel drug targets.
John P.A. Ioannidis
C. F. Rehnborg Professor in Disease Prevention in the School of Medicine and Professor of Health Research and Policy (Epidemiology) and, by courtesy, of Statistics
Current Research and Scholarly Interests Meta-research
Clinical and molecular epidemiology
Human genome epidemiology
Reporting of research
Empirical evaluation of bias in research
Statistical methods and modeling
Meta-analysis and large-scale evidence
Prognosis, predictive and personalized medicine and health
Sociology of science
Associate Professor of Medicine (Pulmonary and Critical Care Medicine)
Current Research and Scholarly Interests Our research program has several active projects:
1.) Pulmonary Vascular Disease Simvastatin reversed experimental pulmonary hypertension, and is safe for treatment of patients. Blinded clinical trials of efficacy are in progress.
2.) Lung inflammation and regeneration (stem cells)
3.) Lung surfactant rheology and oxidative stress
4.) Gene regulation by RNA binding proteins, NF45 and NF90 through transcriptional and posttranscriptional mechanisms
Kiran Kaur Khush, MD, MAS
Associate Professor of Medicine (Cardiovascular Medicine) at the Stanford University Medical Center
Current Research and Scholarly Interests Dr. Khush's clinical research interests include the evaluation of donors and recipients for heart transplantation; mechanisms of adverse outcomes after heart transplantation, including cardiac allograft vasculopathy and antibody-mediated rejection; and development of non-invasive diagnostic approaches for post-transplant monitoring.
Seung K. Kim M.D., Ph.D.
Professor of Developmental Biology and, by courtesy, of Medicine (Oncology)
Current Research and Scholarly Interests We study the genetics of pancreatic islet cell differentiation using molecular, embryologic and genetic methods in several model systems, including mice, embryonic stem cells, and Drosophila. Our work suggests that critical factors required for islet development are also needed to maintain essential functions of the mature islet. Our knowledge of genetic and cellular pathways governing islet formation has allowed us to use stem cell lines to produce islet replacements in vitro.
Abby C. King
Professor of Health Research and Policy (Epidemiology) and of Medicine (Stanford Prevention Research Center)
Current Research and Scholarly Interests My interests include the application of behavioral theory and social ecological approaches to achieve large scale changes impacting chronic disease prevention and control; expanding the reach and translation of evidence-based interventions through state-of-the-art technologies; exploring social and physical environmental influences on health; applying community participatory research perspectives to address health disparities; and policy-level approaches to health promotion/disease prevention.
Joshua W. Knowles
Assistant Professor of Medicine (Cardiovascular Medicine) at the Stanford University Medical Center
Current Research and Scholarly Interests Genetic basis of coronary disease
Genetic basis of insulin resistance
Familial Hypercholesterolemia (FH)
Helene Irwin Fagan Chair in Cardiology and Professor, by courtesy, of Chemical and Systems Biology
Current Research and Scholarly Interests Structure, function and physiology of adrenergic receptors.
Nishita Kothary, MD
Associate Professor of Radiology (General Radiology) at the Stanford University Medical Center
Current Research and Scholarly Interests Interventional Oncology: Percutaneous and transarterial interventions for diagnosis and treatment of primary and metastatic tumors (lung, liver and renal)
Gastrointestinal and Hepatic Oncology
Stanford University Professor in Endocrinology
Current Research and Scholarly Interests Our research interests are in the general area of cellular lipid and lipoprotein metabolism. The work is aimed primarily at understanding the mechanisms regulating cholesterol and triglyceride accumulation in cells. We utilize a variety of techniques from cell biology, biochemistry, and molecular biology.
Professor of Biochemistry
Current Research and Scholarly Interests - Lung development and stem cells
- Neural circuit of breathing
- Lung diseases including lung cancer
- New genetic model organisms for medicine
Professor of Mechanical Engineering and, by courtesy, of Bioengineering
Current Research and Scholarly Interests computaitonal simulation of brain development, cortical folding, computational simulation of cardiac disease, heart failure, left ventricular remodeling, electrophysiology, excitation-contraction coupling, computer-guided surgical planning, patient-specific simulation
Maureen Lyles D'Ambrogio Professor and Professor, by courtesy, of Chemical and Systems Biology
Current Research and Scholarly Interests We study angiogenesis, cancer genomics, intestinal stem cells (ISC), and hepatic glucose metabolism. We use primary organoid cultures of diverse tissues for oncogene functional screening and therapeutics discovery. Angiogenesis projects include endothelial miRNA and GPCR ko mice, blood-brain barrier regulation, stroke therapeutics and anti-angiogenic cancer therapy. ISC projects apply organoid culture and ko mice to injury-inducible vs homeostatic stem cells and symmetric division mechanisms.
Laura C. Lazzeroni, Ph.D.
Associate Professor (Research) of Psychiatry and Behavioral Sciences (General Psychiatry and Psychology-Adult) and, by courtesy, of Medicine (Cardiovascular Medicine) and of Biomedical Data Science
Current Research and Scholarly Interests Biostatistics/biomathematics. I develop & implement models, methods & algorithms for complex data in medical science. I am also interested in the interplay between fundamental statistical properties (e.g. variability, bias, significance, replication) and how scientists actually use and interpret data. My work is in statistical genetics includes: the Plaid biclustering model for gene expression; twin, association, and family studies; pharmacogenetics & large-scale multiple testing & estimation.
Anson M. Lee, MD
Assistant Professor of Cardiothoracic Surgery (Adult Cardiac Surgery) at the Stanford University Medical Center
Bio Dr. Anson Lee specializes in the surgical treatment of all heart diseases, including ischemic heart disease, structural heart disease, aortic disease, and arrhythmias. He has practiced cardiothoracic surgery at Stanford since 2015. Dr. Lee has a special interest in the surgical treatment of abnormal heart rhythms and minimally invasive techniques to treat heart disease.
David Lee, MD
Associate Professor of Medicine (Cardiovascular Medicine) at the Stanford University Medical Center
Current Research and Scholarly Interests 1. Novel treatments and devices for the treatment of vaulvular disease
2. Alcohol septal ablation for hypertrophic obstructive cardiomyopathy
3. Novel approaches to coronary revascularization
4. Closure devices for atrial septal defects and patent foramen ovale
Associate Director, Cardiovascular Institute Operations
Bio Hana Lee, MPH is the Associate Director of the Stanford Cardiovascular Institute (CVI). Prior to this appointment, she was the Director of Strategic Initiatives at the Stanford Center for Population Health Sciences and an epidemiologist at the University of California, San Francisco.
Jason T. Lee
Professor of Surgery (Vascular Surgery) at the Stanford University Medical Center
Current Research and Scholarly Interests Dr. Lee is the Principal Investigator on several clinical trials examining therapeutic strategies for management of cerebrovascular disease, claudication and limb salvage, and complex aortic aneurysm disease.
Dr. Lees clinical interests include:
Endovascular repair of abdominal/thoracic aneurysms
Fenestrated and Branch Repair of the aorta
Endovascular lower extremity procedures
Thoracic outlet syndrome
Vascular disorders in high-performance athletes
So Ah Lee
Postdoctoral Research Fellow, Cardiovascular Institute
Bio Soah is a biomaterials scientist and bio engineer who specializes in developing artificial cell niche using hydrogels for various tissue engineering/drug delivery applications.
During 5 years of Ph.D. training in Stem Cell and Biomaterials Laboratory under Dr. Fan Yang's guidance, Soah has focused on developing novel hydrogel-based cell niche platforms and examining effect of biophysical properties of the cell niche using various natural polymers (Matrigel, collagen, alginate, etc.) and synthetic polymers (poly(ethylene glycol), poly(acryl amide) etc.).
After completion of her Ph.D. training, she has joined Sean Wu's lab in CVI to extend her expertise in biomaterials to develop a bioink for bioprinting 3D cardiac tissues.