School of Medicine
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Manish J. Butte, MD PhD
Assistant Professor, Pediatrics - Immunology and Allergy
Current Research and Scholarly Interests Our laboratory's goal is to address fundamental and therapeutic questions in immunology using innovative nanotechnological and biophysical approaches to visualize and manipulate cells. Our primary focus is on understanding the molecular controls that balance T cell activation versus tolerance. The ultimate aim of our work is to manipulate T cell signaling pathways to control immunologically-mediated diseases.
Professor (Research) of Pediatrics, Emerita
Current Research and Scholarly Interests Our group uses molecular biology, biochemistry, and cellular immunology to investigate the activation and effector function of T lymphocytes. Research in the laboratory is currently focused on three areas: granulysin, a lytic molecule expressed late (7-12 days) after T cell activation; identification of correlates of immunity in diseases such as tuberculosis; and tolerance. The long term goal of this work is to develop new ways to treat human disease.
David B. Lewis M.D.
Professor of Pediatrics (Immunology) at the Lucile Salter Packard Children's Hospital
Current Research and Scholarly Interests My laboratory has two major research interests. First, to define cellular and molecular mechanisms that limit T cell responses to vaccines and pathogens during normal early postnatal development and in cases of inherited genetic immunodeficiencies. Second, to determine how these limitations in immunity can be overcome by using novel approaches for vaccine adjuvants, with a particular focus on anti-viral vaccines.
Clinical Associate Professor, Pediatrics - Immunology and Allergy
Current Research and Scholarly Interests Bioinformatics
Kari Nadeau, MD, PhD
Professor of Medicine (Pulmonary and Critical Care Medicine), of Pediatrics (Allergy and Clinical Immunology) and, by courtesy, of Otolaryngology - Head and Neck Surgery at the Lucile Salter Packard Children's Hospital
Current Research and Scholarly Interests Kari Nadeau, MD, PhD, Allergy, Immunology and Asthma
Our research interests in the laboratory focus on the role of human T cells, specifically natural regulatory T cells (Treg, in immunological diseases. We aim to differentiate the mechanisms of action of regulatory T cell suppressive function. We study how pollution, such as diesel exhause, disrupt Treg suppressive function and how chemokines, like lymphotactin, enhance Treg suppressive function. We also study Treg function in tolerance.