School of Medicine
Showing 1-10 of 20 Results
Jonathan S. Berek, MD, MMS
Laurie Kraus Lacob Professor
Bio Chair, Department of Obstetrics and Gynecology
Clinical Assistant Professor, Obstetrics & Gynecology - Gynecologic Oncology
Bio Dr. Diana P. English is presently a Clinical Assistant Professor in Gynecologic Oncology at Stanford Hospital and Clinics. Dr. English received her medical school training at The University of the West Indies, Mona Campus, Jamaica where she graduated with honors. After graduating from medical school in 2005, she then worked as an intern followed by working as a medical officer in Jamaica for 2 years before starting residency in Obstetrics and Gynecology at University of Miami/Jackson Memorial Hospital in Florida. After completing residency, she began fellowship training in Gynecologic Oncology at Yale University in 2012. Following her fellowship, Dr. English joined the Gynecologic Oncology team at Stanford Hospital and Clinics.
Dr. English has shown herself to be a dedicated researcher and has several original research papers related to targeted therapeutic approaches to Uterine Serous Carcinoma with several publications in high impact journals.
She maintains an interest in serving her community as well and has had the opportunity to work as the American Congress of Obstetricians and Gynecologists (ACOG) Junior Fellow Chair for the Florida section (2011-2012). She also has a strong interest in international service particularly medical mission trips to developing countries.
Her main interests include
•Cancer prevention strategies
•Health disparities in gynecologic oncology
Outside of work, Dr. English maintains an avid interest in playing and watching sport when the time allows.
Huanhuan (Mahsa) He
Postdoctoral Research Fellow, Gynecologic Oncology
Bio What is the role of macrophages in human body? What do they do under different physiological and pathological settings? During my Ph.D. training with Dr. Luisa Iruela-Arispe, my research was focusing on the biological consequences of the interactions between macrophages and endothelial cells. These two types of cells are known to engage in tight and specific interactions that contribute to vascular and oncogenic diseases. The findings from my work (He et al., 2012, Blood) uncovered a critical role for endothelial cells in the induction of M2- macrophage differentiation, which is relevant to the progression of angiogenesis in both developmental and pathological settings. Subsequently, my research on the association between macrophages and endothelial cells in vivo demonstrated that M2-like resident macrophages play a crucial role in regulating vessel permeability through direct cell-cell interactions.
For postdoctoral research, I'm attempting to apply the knowledge of macrophages to oncology field and focus on the role of macrophages in ovarian cancer. In ovarian cancer, more than 75% of mononuclear immune cells close to a tumor are tumor-associated macrophages (TAMs; Wang et al., 2006). Although it has been suggested that macrophages can potentially promote tumor invasion, migration and angiogenesis, no study has yet extensively addressed the role of macrophages in ovarian cancer (Pollard, 2004). We hypothesize that macrophages mediate tumor growth and metastasis through direct interaction with ovarian cancer cells. They play a potential role in regulating cancer cell proliferation, migration and/or survival. We will establish an in vivo imaging model where macrophages can be traced and monitored and their functions can be broadly explored. Such study will provide information on the various mechanisms by which macrophages affect cancer progression, which potentially will lead to the treatment for ovarian cancer and even other types of cancer.