School of Medicine
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Professor of Medicine (Hematology) and, by courtesy, of Chemical and Systems Biology
Current Research and Scholarly Interests We study angiogenesis, cancer genomics, intestinal stem cells (ISC), and hepatic glucose metabolism. We use primary organoid cultures of diverse tissues for oncogene functional screening and therapeutics discovery. Angiogenesis projects include endothelial miRNA and GPCR ko mice, blood-brain barrier regulation, stroke therapeutics and anti-angiogenic cancer therapy. ISC projects apply organoid culture and ko mice to injury-inducible vs homeostatic stem cells and symmetric division mechanisms.
Joseph (Joe) Lipsick
Professor of Pathology, Genetics and, by courtesy, of Biology
Current Research and Scholarly Interests Function and evolution of the Myb oncogene family; function and evolution of E2F transcriptional regulators and RB tumor suppressors; epigenetic regulation of chromatin and chromosomes; cancer genetics.
Assistant Professor of Molecular and Cellular Physiology
Current Research and Scholarly Interests We study the primary cilium, a once-obscure cellular organelle recently "re-discovered" for its role in a number of signaling pathways. Defects in cilium biogenesis lead to a variety of hereditary disorders characterized by retinal degeneration, kidney cysts and obesity. Our goal is to characterize these disorders at the molecular and cellular levels to gain insight into the basic mechanisms of primary cilium biogenesis and to discover novel ciliary signaling pathways.
Rudy J. and Daphne Donohue Munzer Professor in the School of Medicine and Professor of Molecular and Cellular Physiology
Current Research and Scholarly Interests Our research objectives are to understand the cellular mechanisms involved in the development and maintenance of epithelial cell polarity. Polarized epithelial cells play fundamental roles in the ontogeny and function of a variety of tissues and organs.
Anthony Oro MD/PhD
Professor of Dermatology
Current Research and Scholarly Interests Our lab uses the skin to answer questions about epithelial stem cell biology, differentiation and carcinogenesis using genomics, genetics, and cell biological techniques. We have studied how hedgehog signaling regulates regeneration and skin cancer, and how tumors evolve to develop resistance. We study the mechanisms of early human skin development using human embryonic stem cells. These fundamentals studies provide a greater understanding of epithelial biology and novel disease therapeutics.
Emma Pfeiffer Merner Professor in the Medical Sciences
Current Research and Scholarly Interests The goal of our research is to elucidate the molecular mechanisms by which proteins are targeted to specific membrane compartments. How do transport vesicles select their contents, bud, translocate through the cytoplasm, and then fuse with their targets? We study the Ras-like Rab GTPases--how they serve as master regulators of all receptor trafficking events. We also study how cells acquire cholesterol from the diet and from LDL.
Associate Professor of Pediatrics (Cancer Biology) and of Genetics
Current Research and Scholarly Interests We investigate the mechanisms by which normal cells become tumor cells, and we combine genetics, genomics, and proteomics approaches to investigate the differences between the proliferative response in response to injury and the hyperproliferative phenotype of cancer cells and to identify novel therapeutic targets in cancer cells.
Stanford W. Ascherman, MD, FACS, Professor in Genetics
Current Research and Scholarly Interests Our laboratory use different omics approaches to study a) regulatory networks, b) intra- and inter-species variation which differs primarily at the level of regulatory information c) human health and disease. For the later we have established integrated Personal Omics Profiling (iPOP), an analysis that combines longitudinal analyses of genomic, transcriptomic, proteomic, metabolomic, DNA methylation, microbiome and autoantibody profiles to monitor healthy and disease states
Associate Professor of Biochemistry amd, by courtesy, of Chemical and Systems Biology
Current Research and Scholarly Interests We study the biology of chromosomes. Our research is focused on understanding how chromosomal domains are specialized for unique functions in chromosome segregation, cell division and cell differentiation. We are particularly interested in the genetic and epigenetic processes that govern vertebrate centromere function, in the organization of the genome in the eukaryotic nucleus and in the roles of RNAs in the regulation of chromosome structure.
Professor of Urology
Current Research and Scholarly Interests We focus on understanding the molecular mechanism of transcription factors that govern the transformation of normal cells to a neoplastic state. We are especially interested in nuclear hormone action and its interactions with other signaling pathways in tumor development and progression.