School of Medicine
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James L. Zehnder, M.D.
Professor of Pathology and of Medicine (Hematology) at the Stanford University Medical Center
Current Research and Scholarly Interests Our laboratory focuses on translational research in 2 main areas - genomic approaches to diagnosis and minimal residual disease testing for patients with cancer, and molecular basis of disorders of thrombosis and hemostasis. My clinical focus is in diagnosis and treatment of disorders of hemostasis and thrombosis and general hematology.
Basic Life Science Research Associate, Pathology Blood Center Sponsored Projects
Bio I received Ph.D. in Cell Biology from Peking University, and had my postdoctoral training in Dr. Jack Strominger’s lab at Harvard University. By using the EAE mouse model, we found a synthetic amino acid copolymer could significantly ameliorate the disease through inducing antigen-specific, IL-10-producing regulatory T cells. After postdoc, I worked in Sanford-Burnham Medical Research Institute from 2010 to 2012 as a Scientist under the supervision of Dr. Salvatore Albani, and we were trying to identify predictive biomarkers for the therapeutical outcome of Juvenile Idiopathic Arthritis patients. I joined Dr. Edgar Engleman’s lab at Stanford University in August 2012 as a Research Associate. My research in Dr. Engleman's lab has been mainly focused on studying the pathogenesis of human autoimmune disease. We found iNKT cells in lupus patients could help B cells to produce autoantibodies including anti-double strand DNA antibodies, and therefore were pathogenic to the disease. More recently, I have been working on human plasmacytoid dendritic cells (pDC), and we have identified a rare but novel human pDC subset which shows distinct phenotype and functions from regular pDCs,
Postdoctoral Research fellow, Pathology
Current Research and Scholarly Interests Immune suppression; Immune tolerance; Dendritic cells; Regulatory myeloid cells; T cell immune responses; GVHD; Transplantation; Autoimmune diseases.