School of Medicine
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Emma Pfeiffer Merner Professor in the Medical Sciences
Current Research and Scholarly Interests The goal of our research is to elucidate the molecular mechanisms by which proteins are targeted to specific membrane compartments. How do transport vesicles select their contents, bud, translocate through the cytoplasm, and then fuse with their targets? We study Rab GTPases-- as master regulators of all receptor trafficking events. We are trying to understand how phosphorylation of Rabs may trigger Parkinson's Disease. We also study how cells acquire cholesterol from the diet and from LDL.