School of Medicine
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Mrs. George A. Winzer Professor in Cell Biology
Current Research and Scholarly Interests CELLULAR INFORMATION PROCESSING The main problem in signal transduction is to understand how different receptor-stimuli specifically control diverse cell functions. We are using automated microscopy, live-cell fluorescent biosensors and perturbations of predicted signaling proteins to systematically dissect signaling networks. This allows us to identify signaling modules and to elucidate and ultimately model the flow of cellular information.
Beverly S. Mitchell, M.D.
George E. Becker Professor in Medicine and Professor, by courtesy, of Chemical and Systems Biology
Current Research and Scholarly Interests Beverly Mitchell's research relates to the development of new therapies for hematologic malignancies, including leukemias and myelodsyplastic syndromes. She is interested in preclinical proof of principle studies on mechanisms inducing cell death and on metabolic targets involving nucleic acid biosynthesis in malignant cells. She is also interested in the translation of these studies into clinical trials.
The George D. Smith Professor in Translational Medicine
Current Research and Scholarly Interests Two areas: 1. Using rationally-designed peptide inhibitors to study protein-protein interactions in cell signaling. We focus on protein kinase C (PKC)-mediated signal transduction and on mitochondrial dynamics in several disease models. 2. Using small molecules (identified in a high throughput screens and synthetic chemistry) as activators and inhibitors of aldehyde dehydrogenases, a family of detoxifying enzymes, we study their involvement in normal cells and in models of human diseases.