School of Medicine
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Professor of Pediatrics (Neonatology) at the Lucile Packard Children's Hospital and, by courtesy, of Obstetrics and Gynecology at the Stanford University Medical Center
Current Research and Scholarly Interests 1. development of hospital operations centers coupled with sophisticated simulation capabilities
2. re-creation of near misses and adverse events
3. optimizing human and system performance during resuscitation
4. optimizing pattern recognition and situational awareness at the bedside
5. evaluation and optimization of debriefing
6. patient simulator design
Huanhuan (Mahsa) He
Postdoctoral Research fellow, Gynecologic Oncology
Bio What is the role of macrophages in human body? What do they do under different physiological and pathological settings? During my Ph.D. training with Dr. Luisa Iruela-Arispe, my research was focusing on the biological consequences of the interactions between macrophages and endothelial cells. These two types of cells are known to engage in tight and specific interactions that contribute to vascular and oncogenic diseases. The findings from my work (He et al., 2012, Blood) uncovered a critical role for endothelial cells in the induction of M2- macrophage differentiation, which is relevant to the progression of angiogenesis in both developmental and pathological settings. Subsequently, my research on the association between macrophages and endothelial cells in vivo demonstrated that M2-like resident macrophages play a crucial role in regulating vessel permeability through direct cell-cell interactions.
For postdoctoral research, I'm attempting to apply the knowledge of macrophages to oncology field and focus on the role of macrophages in ovarian cancer. In ovarian cancer, more than 75% of mononuclear immune cells close to a tumor are tumor-associated macrophages (TAMs; Wang et al., 2006). Although it has been suggested that macrophages can potentially promote tumor invasion, migration and angiogenesis, no study has yet extensively addressed the role of macrophages in ovarian cancer (Pollard, 2004). We hypothesize that macrophages mediate tumor growth and metastasis through direct interaction with ovarian cancer cells. They play a potential role in regulating cancer cell proliferation, migration and/or survival. We will establish an in vivo imaging model where macrophages can be traced and monitored and their functions can be broadly explored. Such study will provide information on the various mechanisms by which macrophages affect cancer progression, which potentially will lead to the treatment for ovarian cancer and even other types of cancer.
Wm. LeRoy Heinrichs
Professor of Obstetrics and Gynecology, Emeritus
Current Research and Scholarly Interests Surgical simulation; team-training in virtual environments; online training of healthcare providers in virtual environments; tele-medicine for acute & chronic disease management in virtual environments
Professor of Obstetrics and Gynecology at the Stanford University Medical Center
Bio Paula J. Adams Hillard, M.D., is Professor of Obstetrics and Gynecology at Stanford University School of Medicine where she serves as Associate Chair for Medical Student Education. She earned a B.S. in Zoology from the University of North Carolina and obtained her M.D. from Stanford University School of Medicine. She completed a residency in OB/Gyn at the University of North Carolina, Chapel Hill. She was on the faculty at the University of Virginia, and served as Professor in the Departments of OB/Gyn and Pediatrics at the Cincinnati Children’s Hospital (CCHMC) /University of Cincinnati Medical Center for 23 years. At CCHMC she was the founder of a postgraduate fellowship in Pediatric and Adolescent Gynecology. She currently directs the program in Adolescent and Pediatric Gynecology at the Lucile Packard Children’s Hospital at Stanford.
She has been active on a number of national medical committees, including chair of the American College Obstetricians and Gynecologists' (ACOG) Committees on Patient Education, Adolescent Health, and Guidelines for Women’s Health; she is a past member of the Gynecologic Practice Committee and the Gynecology Document Review Committee, and is currently a member of the Ethics Committee. She has been an examiner for the American Board of Obstetricians and Gynecologists since 1991. She is a Board Member of the Association of Professors of Gynecology and Obstetrics, and was elected a fellow of the American Gynecological and Obstetrical Society. She is a past president of the North American Society for Pediatric and Adolescent Gynecology, and is an active contributor to the literature in adolescent gynecology and contraception with over 160 journal articles and abstracts published. She is the sole editor of two textbooks: the 5-Minute Consult in Obstetrics and Gynecology (2008) and Practical Pediatric and Adolescent Gynecology (2013). She is the author of over 140 peer -reviewed articles and abstracts, and over 100 book chapters on women’s health. She has been a consultant and a member of tasks forces and committees for the CDC, the U.S. FDA, the NICHD, the AMA, American Cancer Society, and ACOG. In addition to her work as a member of editorial boards and as an ad hoc reviewer for professional publications, Dr. Hillard has extensive experience with the consumer press. She was a contributing editor to Parents magazine from 1982-1990, writing a monthly column on pregnancy and birth--and currently acts as an editorial consultant to women’s publications such as Good Housekeeping, Family Circle, Woman’s Day, Cosmopolitan, Redbook, Glamour, YM, and Seventeen, as well as ABC News. She has been recognized for her teaching, and has been selected as one of 15 senior faculty master teachers/mentors for medical students at the Stanford University School of Medicine in a formal mentoring program called Educators for CARE: Compassion, Advocacy, Responsibility, and Empathy.
Professor of Obstetrics and Gynecology (Reproductive and Stem Cell Biology)
Current Research and Scholarly Interests Hormonal regulation of ovarian function; gonadotropin receptors and related genes, bioinformatic ananlyses of polypeptide hormones and receptors, follicle recruitment and GDF-9; analysis of oocyte and ovarian-expressed genes.
Professor of Pediatrics (Genetics) at the Lucile Salter Packard Children's Hospital and, by courtesy, of Obstetrics and Gynecology at the Stanford University Medical Center
Current Research and Scholarly Interests I am interested in prenatal genetic screening and diagnosis.