School of Medicine

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  • Pratyush Gupta

    Pratyush Gupta

    Postdoctoral Research fellow, Chemical and Systems Biology

    Current Research and Scholarly Interests Diabetes and insulin-resistance affect a staggering 8.3% of world’s population and are a leading cause of death worldwide (World Health Organization). It has a huge impact on global health. Diabetes is the seventh leading cause of death in U.S. and more than 1/3 of U.S. population is resistant to insulin (American Diabetes Association). Insulin-resistance is tightly linked to adipocyte differentiation dysfunction and to defects in adipogenesis. Thus, it becomes necessary to study the molecular and genetic implications of adipogenesis in order to understand mechanisms that can help us to treat insulin-resistance and diabetes. Adipocytes store fat and since accumulation of fat (or obesity) is directly related to development of insulin-resistance, proper control of adipogenesis can link to regulation of accumulation of fat and help us develop strategies to prevent diabetes. That is the goal of this research – to understand how adipocyte differentiation is regulated and use that information to develop therapeutics. The overall goal is find out what feedback loops participate in controlling the terminal differentiation rate of adipocytes as a means to control fat storage and prevent insulin-resistance and diabetes. Through this research, I intend to investigate how post-translational regulation such as proteasomal-degradation, sumoylation and neddylation are involved in mediating the differentiation switch and adipogenesis. This knowledge will be crucial in developing therapeutic strategies to prevent insulin-resistance and diabetes. Diabetes being a leading cause of concern for people, my research will have significant positive consequences on the health of people throughout the world.