School of Medicine
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Jens Durruthy Durruthy
Postdoctoral Research fellow, Stem Cell Biology and Regenerative Medicine
Current Research and Scholarly Interests I graduated from Stanford University and Technical University Berlin in a joined program with a PhD in biomedical engineering in 2014. During my PhD I developed a transplantation model in which undifferentiated RNA-derived human induced pluripotent stem cells are transplanted into mouse testes to study early-stage germ cell formation. I am currently a postdoctoral fellow at Stanford University and pursue my interest in human stem cell research, RNA biology and early human embryo development. Specifically, my research focuses on exploring a novel class of long noncoding RNAs that are of retroviral origin and pluripotent specific. I study the underlying mechanisms of how long noncoding RNAs are regulating pluripotency acquisition and maintenance of human stem cells on a single cell level.
Moreover, I study human preimplantation embryo development and the complex dynamic cellular and molecular events that lead to the formation of all three lineages of the blastocyst (trophectoderm, epiblast, primitive endoderm). In particular, I use high throughput single-cell quantitative RT-PCR gene expression analysis to uncover crucial new insights into the earliest cell differentiation events of the human preimplantation embryo. I further extend this analysis on a genome wide level (RNA-seq) to assess the transcriptional profile characteristic of single cells to eventually reconstruct a gene expression map of the human blastocyst.