School of Medicine


Showing 1,311-1,320 of 1,334 Results

  • Xiaoyi Zheng

    Xiaoyi Zheng

    Postdoctoral Research fellow, Nephrology

    Current Research and Scholarly Interests I hope you have a happy day with your research!

    Nephrology (postdoc 2013-current)

    Diabetes causes kidney disease in 40% of the patients, and people don`t know which gene(s) causes the differential susceptibility to kidney disease. By using modern biotechnology such as microarray, I aim to identify the genes that cause diabetic kidney disease. These genes may become biomarkers for early diagnosis or new therapeutic targets for treatments. My expertise includes primary cell isolation and flow cytometry, IHC/IF (paraffin and frozen), WB/qPCR, establishing ELISA methods, chromatography, cell culture, animals/i.v. injection/hydrodynamic injection. I have a 3-year postdoctoral fellowship from Larry L. Hillblom Foundation.

    Cancer (Ph.D 2009-2013)

    Late diagnosis of cancer often causes death due to metastasis. By establishing ELISA method to detect a new cancer marker, I aim to detect cancer early so that the doctors can eliminate death. This new cancer marker and ELISA method are patented or under patent application. I further studied the biological function of this cancer marker to discover a new therapeutic target.

    Communication facilitator (2014-current)

    A scientist needs communications to promote their research. I learned scientific communication in Stanford Leadership in Communication (workshop), and later become a facilitator in the workshop to coach beginners.

  • Bo Zhou

    Bo Zhou

    Postdoctoral Research fellow, Neurosciences

    Current Research and Scholarly Interests Genetic information encoded in our DNA sequence are inherited from our parents and determine our own unique appearance and predisposition to certain diseases. Recent scientific findings have revealed that patterns of molecular modification (methylation) on the Cs in our DNA sequence can also be inherited from our parents. These methylation patterns vary from individual to individual and regulate important biological processes inside the various cell types of our bodies. Although the mechanisms of how these methylation patterns regulate biological processes is very poorly understood, more and more cases have confirmed that diseases including many types of cancer may develop when erroneous DNA methylation occurs in an individual. Interestingly, in many instances, the DNA sequences inherited paternally and maternally are asymmetrically methylated, and this phenomenon, also known as imprinting, has been associated with the preferential silencing of either paternally or maternally inherited genes. Though this phenomenon is thought to occur throughout our DNA, due to mainly technological limitations, only a handful of such imprinted genes has been identified in humans, and as a result, very little is known about how the process of imprinting regulates our biology in healthy or diseased states including cancer, neurological disorders, and possibly psychiatric illnesses as well. I am interested in developing a method to not only capture the entire methylation pattern in one’s DNA but also place this this pattern in the context of paternal and maternal inheritance such that all the imprinted regions in one’s DNA can also be identified. Such a method will serve as an important stepping-stone in furthering our understanding of the rules and mechanisms that govern the biology of DNA methylation and how to leverage them in the treatment of human disease.