School of Medicine

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  • Maral Tajerian

    Maral Tajerian

    Postdoctoral Research Fellow, Anesthesiology, Perioperative and Pain Medicine

    Bio Chronic pain affects millions of people worldwide and is a serious socioeconomic problem. Unfortunately, pain mechanisms are poorly understood, often resulting in inadequate treatment outcomes where the vast majority of individuals suffer for years with little relief. Fortunately, in the last decade, we have witnessed an increased enthusiasm in the field of pain research; a trend that is very encouraging for the millions of pain sufferers worldwide.
    My PhD work has focused on a very prevalent condition: chronic low back pain. The main emphasis was on the mechanisms of back pain in a mouse model and we were fortunate enough to translate our findings to humans. Interestingly, we were also the first group to report the link between DNA methylation and pain; a field that is currently advancing very rapidly since it provides a molecular mechanism of environment-gene interactions. In addition to our back pain studies, we have also carried out research examining the brain changes that occur after peripheral nerve injury, with particular emphasis on reversible methylation changes in the prefrontal cortex. Our findings provide the molecular link between peripheral nerve injury and changes in the brain, thus helping us account for the co-morbidities associated with pain. These formative years at the Alan Edwards Center for Research on Pain (AECRP) have given me a solid training in the field of pain research.
    I began my postdoctoral training at Stanford University in 2013, where I chose to study another debilitating chronic pain condition, Complex Regional Pain Syndrome (CRPS). Using a previously-validated mouse model of CRPS, we could show that pain-associated comorbidities are paralleled by dendritic architectural changes in various brain regions. In parallel, I developed a novel interest in the autoimmune mechanisms of CRPS, an area that remains largely unexplored. We believe this line of investigation to be paradigm shifting; indeed, approaching CRPS as an autoimmune disease opens entirely new experimental pathways to identifying specific supporting mechanisms and provides opportunities for novel therapeutic development.
    In addition to laboratory research, I am passionate about science outreach in general and pain outreach in particular. I believe it is our responsibility as scientists to disseminate our knowledge to the layperson, particularly since chronic pain is a widespread condition with significant socioeconomic impact. To that end, I am an avid participant in pain awareness efforts through public lectures and social media involvement.

  • Michal Tal

    Michal Tal

    Postdoctoral Research Fellow, Stem Cell Biology and Regenerative Medicine

    Current Research and Scholarly Interests Investigating how the CD47-SIRPa axis modulates multiple facets of immunity

  • Susanna Tan

    Susanna Tan

    Postdoctoral Medical Fellow, Infectious Diseases

    Bio I am an infectious diseases-trained physician-investigator dedicated to translating novel diagnostics and diagnostic strategies that advance the management of infections in transplantation. My research focuses on the use of next-generation sequencing (NGS) to better understand and improve the care of viral infections in transplant recipients. I evaluate novel virus-disease associations, the virome in transplantation, and host-virus responses in solid organ and hematopoietic cell transplant recipients. I perform clinical validation and utility studies of NGS-based broad pathogen assays and targeted assays based on NGS-derived findings. I have particular interests in polyomaviruses and donor-derived infections in solid organ transplantation.