School of Medicine
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Professor of Molecular and Cellular Physiology, of Neurology and Neurological Sciences, of Photon Science and, by courtesy, of Structural Biology
Current Research and Scholarly Interests One of Axel Brunger's major goals is to decipher the molecular mechanisms of synaptic neurotransmitter release by conducting single-molecule/particle reconstitution and imaging experiments, combined with high-resolution structural studies of the synaptic vesicle fusion machinery. A second goal is to develop advanced biomolecular imaging methods at the molecular scale.
Assistant Professor of Molecular and Cellular Physiology
Current Research and Scholarly Interests We are interested in the structure, dynamics and function of eukaryotic transport proteins mediating ions and major nutrients crossing the membrane, the kinetics and regulation of transport processes, the catalytic mechanism of membrane embedded enzymes and the development of small molecule modulators based on the structure and function of membrane proteins.
Professor of Molecular and Cellular Physiology and of Structural Biology
Current Research and Scholarly Interests Structural and functional studies of transmembrane receptor interactions with their ligands in systems relevant to human health and disease - primarily in immunity, infection, and neurobiology. We study these problems using protein engineering, structural, biochemical, and combinatorial biology approaches.
Miriam B. Goodman
Associate Professor of Molecular and Cellular Physiology and, by courtesy, of Mechanical Engineering
Current Research and Scholarly Interests We study the molecular events that give rise to the sensation of touch and temperature in C. elegans. To do this, we use a combination of quantitative behavioral analysis, genetics, in vivo electrophysiology, and heterologous expression of ion channels. We also collaborate with Pruitt's group in Mechanical Engineering to develop and fabricate novel devices for the study of sensory transduction.
Professor of Neurology, of Neurosurgery and, by courtesy, of Molecular and Cellular Physiology
Current Research and Scholarly Interests We are interested in the neuronal mechanisms that underlie synchronous oscillatory activity in the thalamus, cortex and the massively interconnected thalamocortical system. Such oscillations are related to cognitive processes, normal sleep activities and certain forms of epilepsy. Our approach is an analysis of the discrete components (cells, synapses, microcircuits) that make up thalamic and cortical circuits, and reconstitution of components into in silico computational networks.
Helene Irwin Fagan Chair in Cardiology and Professor, by courtesy, of Chemical and Systems Biology
Current Research and Scholarly Interests Structure, function and physiology of adrenergic receptors.
Professor of Molecular and Cellular Physiology
Current Research and Scholarly Interests We study molecular mechanisms of calcium signaling with a focus on store-operated CRAC channels and their essential roles in T cell development and function. Currently we aim to define the molecular mechanism for CRAC channel activation and the means by which calcium signal dynamics mediate specific activation of transcription factors and T-cell genes during development.
Daniel V. Madison
Associate Professor of Molecular and Cellular Physiology
Current Research and Scholarly Interests Our laboratory is interested in the function and plasticity CNS synapses, including studies of the detailed structure and protein content of synapses in different plastic states. We also have a strong interest in the pathophysiology of Azheimer’s disease as related to endocannabinoids. We use primarily electrophysiogy and high-resolution array tomographic imaging to dissect the function of synapses undergoing changes due either to external stimuli, disease states or internal modulation.