Master of Science in Engr, Technical University of Denmark (2005)
Doctor of Philosophy, Kjobenhavns Universitet (2011)
Jianghong Rao, Postdoctoral Faculty Sponsor
Drug Design: An (18) F-labeled caspase-3-sensitive nanoaggregation positron emission tomography tracer was prepared and evaluated for imaging the caspase-3 activity in doxorubicin-treated tumor xenografts. Enhanced retention of the (18) F activity in apoptotic tumors is achieved through intramolecular macrocyclization and in situ aggregation upon caspase-3 activation.
View details for DOI 10.1002/anie.201303422
View details for Web of Science ID 000325091500023