Current Research and Scholarly Interests
As Director of the Pediatric Bipolar Disorders Program, Dr. Chang conducts research into various facets of bipolar disorder. He is currently conducting phenomenologic, biologic, pharmacologic, and genetic studies of bipolar disorder in adults and children. These studies include brain imaging (MRI, MRS, fMRI) and medication and therapy trials. He is particularly interested in detecting prodromal bipolar disorder in children who might then be treated to prevent the development of full bipolar disorder. To do this, he has been studying children of parents with bipolar disorder who are at high risk for developing the disorder themselves.
As Director of the PANS Research Program, an offshoot of the PBDP, Dr. Chang is investigating underlying causes for the acute neuropsychiatric symptoms in these children. In conjunction with the PANS Clinic at LPCH, he is collecting phenomenological, immunologic, and brain imaging data, the first study ever to investigate this illness in this way.