Current Research and Scholarly Interests
I wish to develop new therapies to prevent and treat the respiratory distress syndrome (RDS) and its sequelae, bronchopulmonary dysplasia (BPD).
Previous research focused on how the lung's airspaces become fluid filled (mechanisms of pulmonary edema) and how airspace fluid is cleared under both physiologic (fetal lung liquid at birth) and pathophysiologic (pulmonary edema) conditions. Since the rate limiting step in airspace fluid clearance is the active transport of Na+ by distal lung epithelium, our studies investigated the effect of lung maturity, mediators and hormones on the pre and post-translational regulation of the epithelial Na+ channel (ENaC).
My current research focuses on identifying the
- genetic factors that explain the heritability of BPD, currently estimated to explain 50-80% of the risk for BPD. We conduct population based studies and have used both Genome Wide Association Studies (GWAS) and exome sequencing.
- perinatal risk factors that are associated with long term clinical outcomes of infants and children with BPD.