Mechanotransduction and fibrosis
JOURNAL OF BIOMECHANICS
2014; 47 (9): 1997-2005
Diabetes impairs the angiogenic potential of adipose-derived stem cells by selectively depleting cellular subpopulations
STEM CELL RESEARCH & THERAPY
Cutaneous innervation of the ankle: An anatomical study showing danger zones for ankle surgery
2014; 27 (4): 653-658
Scarring and tissue fibrosis represent a significant source of morbidity in the United States. Despite considerable research focused on elucidating the mechanisms underlying cutaneous scar formation, effective clinical therapies are still in the early stages of development. A thorough understanding of the various signaling pathways involved is essential to formulate strategies to combat fibrosis and scarring. While initial efforts focused primarily on the biochemical mechanisms involved in scar formation, more recent research has revealed a central role for mechanical forces in modulating these pathways. Mechanotransduction, which refers to the mechanisms by which mechanical forces are converted to biochemical stimuli, has been closely linked to inflammation and fibrosis and is believed to play a critical role in scarring. This review provides an overview of our current understanding of the mechanisms underlying scar formation, with an emphasis on the relationship between mechanotransduction pathways and their therapeutic implications.
View details for DOI 10.1016/j.jbiomech.2014.03.031
View details for Web of Science ID 000338621900009
Time is money: a faster way of Steri-Strip application (the 3-finger technique).
Aesthetic surgery journal
2013; 33 (6): 924-925
Three nerves innervate the skin in the foot and ankle region: the saphenous, sural, and superficial peroneal nerves. Because they are close to the medial and lateral malleoli, these nerves are at significant risk during orthopedic interventions. The aims of this study were to investigate the distal courses of the three cutaneous nerves of the ankle and to determine their exact relationships with easily identifiable bony landmarks. Ten freshly frozen and 40 embalmed lower extremities of adults were dissected. The positions of the superficial peroneal, sural, and saphenous nerves were determined using reference lines based on easily palpable osseous landmarks. The frequencies and distributions of all three nerves and their branches were converted into absolute numbers. A danger zone for each nerve was established on the basis of the distribution of crossings between the nerves and the different reference lines. Determination of the exact orientation of the nerves around the ankle should help minimize the nerve injury rate during surgical approaches in this area. Using this easily translatable new grid system, the course and danger zones of each cutaneous nerve around the ankle can be estimated clinically. Clin. Anat., 2013. © 2013 Wiley Periodicals, Inc.
View details for DOI 10.1002/ca.22347
View details for Web of Science ID 000333922000020
View details for PubMedID 24343871