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An NIH Training Program |
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Center for Cancer Nanotechnology Excellence focused on Therapeutic Response (CCNE-TR) Sanjiv Sam Gambhir, M.D., Ph.D., Principal Investigator This research is centered around our strong belief that ex vivo diagnostics used in conjunction with in vivo diagnostics can markedly impact future cancer patient management. Furthermore, we believe that nanotechnology can significantly advance both ex vivo diagnostics through proteomic nanosensors and in vivo diagnostics through nanoparticles for molecular imaging. Either the ex vivo or in vivo strategy alone will not be optimal; both together will likely provide significant synergy. Clinical tools are lacking to reliably predict which individuals will respond, or to monitor response to a specific anti-cancer therapy regimen. The goal of this grant is the development and validation of nanotechnology in order to eventually predict which patients will likely respond to a specific anti-cancer therapy, and monitor response to therapy. Both the use of ex vivo protein nannosensors and in vivo nanoparticles (quantum dots) for molecular imaging are pursued in an integrated cohesive five year plan. Web Site: http://mips.stanford.edu/public/grants/ccne/ In Vivo Cellular and Molecular Imaging Center (ICMIC) Sanjiv Sam Gambhir, M.D., Ph.D., Principal Investigator The vision of ICMIC@Stanford is to bring together researchers from various disciplines to form synergistic teams that will make significant advances in the use of multimodality molecular imaging strategies for better linking pre-clinical models of cancer with the clinical management of cancer. Members of these teams will include trainees that will gain access to a highly multidisciplinary experience, and who will become well-equipped to establish independent, multidisciplinary research programs. Web Site: http://mips.stanford.edu/public/grants/icmic/ The Network for Translational Research in Optical Imaging (NTROI) Christopher Contag, Ph.D., Principal Investigator In this project, an interdisciplinary team of investigators at Stanford University, and partner institutions, is involved in a translational research program that combines imaging-technology development with biomarker discovery for the early detection of cancer in the esophagus. New imaging technologies have often been a key to the early detection and treatment of cancer. In this project, a unique endoscopic imaging tool that performs a noninvasive "optical biopsy" of esophagus tissues is being developed for detecting pre-cancerous conditions in the esophagus. The power of this tool, the miniature dual-axes confocal microscope, is that it images tissue structure with enough clarity and resolution to identify pre-cancerous tissues. This technology is also compatible with the use of optically-labeled biomarkers being developed in our group to specifically tag and identify pre-cancerous tissues. The combination of developing an advanced imaging technology, which greatly improves upon current in vivo imaging techniques, as well as the development of biomarkers specifically formulated for use with this imaging technology to locate pre-cancerous tissues, is an extremely powerful strategy. Web Site: http://ntroi.stanford.edu/ Integrative Cancer Biology Program Sylvia K. Plevritis, Ph.D., Principal Investigator Genomic and proteomic probes of cancerous and normal tissue require new computational methods for data analysis. Our goal is to develop the computational tools that will aid in the discovery of molecular perturbations implicated in cancer initiation and progression. We aim to elucidate the genetic, signaling and metabolic pathways of malignant processes through the integration of experimentation and computational methods. By revealing the molecular pathways of cancer, our work promises to advance the basic knowledge of the disease and enable the development of molecularly targeted therapies that will ultimately reduce cancer mortality. Web Site: http://rsl.stanford.edu/icbp/index.html Center for Advanced Magnetic Resonance Technology at Stanford Gary Glover, Ph.D., Principal Investigator The Center for Advanced Magnetic Resonance Technology at Stanford (CAMRT) was established as a National Research Resource in January 1995. The Center joins the Radiology Department's Richard M. Lucas Center for Magnetic Resonance Spectroscopy and Imaging with those of the Electrical Engineering Department's Magnetic Resonance Systems Research Laboratory toward the common goals of developing innovative Magnetic Resonance Imaging and Spectroscopy (MRI/MRS) techniques for fundamental anatomic, physiologic and pathophysiologic studies, and serving the academic and scientific community through collaborations, education and access to Center facilities and resources. Our mission is to develop innovative MR technology and make it widely available to users and students locally and nationwide. Core development is motivated by (1) core director's vision for technology advancement, (2) potential for future hypothesis-driven research, (3) medical need and potential health impact, (4) opportunity for collaboration and feedback from collaborators, (5) service application. Web site: http://rsl.stanford.edu/research/camrt.html |
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