Cellular Pathway Imaging Laboratory (CPIL)
Ramasamy Paulmurugan
|
The main focus of this laboratory is to develop in vivo imaging strategies that can be used to study signal transduction at different stages of its network, starting from the extracellular stimulus along the path until the nucleus. Signal transduction is a regulated biochemical process by which cells convert extracellular stimuli into functional changes within the cell. This network involves many proteins, small molecule ligands and other physical agents. The intact signal transduction network plays a key role in maintaining the cells at their normal functional state. The break in the signal transduction network contributes for cells to undergo different pathological status including cancer. Currently, we are working on signal transduction imaging of estrogen receptor. Estrogen receptor is a ligand inducible transcription factor that plays an important role in the development, progression, invasiveness and response to therapy, in breast cancer. The multimodality molecular imaging approach in conjunction with the split-reporter complementation system is used to achieve this target. |
List of all MIPS Faculty and Staff
|
