Signal Transduction Imaging and Engineering (STIE)
Michael Lin
This laboratory performs protein engineering to develop genetically encoded fluorescent reporters of cellular processes and methods for exogenous control of protein functions. We are particularly interested in protein translation pathways involved in cellular differentiation and cancer development in mammals. Current projects include the development of fluorescent proteins with optical properties suitable for deep-tissue imaging in mammals, the development of fluorescent protein pairs suitable for fluorescence resonance energy transfer-based biosensing in whole- animals, and the design of new reporters for protein translation pathways. We are also further improving methods for controlling protein tagging in vivo with drugs using the "TimeSTAMP system" to track protein translation products in real time and control protein translation with high speed. These technologies are being used to study aberrations of protein translation in disease and to tune the activity of gene therapies using drugs.
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