Our lab's goals are twofold, the first is a translational area of research, the second is more basic.

• To improve cancer therapy by exploiting the low oxygenation and presence of necrosis in solid tumors. We are doing this by developing new drugs that are active in killing cells only at low oxygenation, and by using non-pathogenic obligate anaerobes to target gene therapy to tumors.
• To find new cancer susceptibility genes using the power of yeast genomics. To do this we are identifying novel genes in S. cerevisiae that are defective in DNA repair or cell cycle checkpoints using new tools including a pool of genome wide deletions of all non-essential genes and modern approaches to identifying protein-protein interactions. Novel candidate genes are followed through mouse knockout studies to test their tumor suppression in vivo.

For more information, please visit the Dr. Brown's Lab website.