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2008 Nanobiotechnology Seminar SeriesSeminar & Discussion 4:30 - 5:30 pmReception 5:30 - 6:00 pm All Seminars will be held in Clark Auditorium Stanford University Campus You will need the free RealPlayer  to view the webcast of lectures and the Adobe Acrobat Reader plugin  to view the abstracts.
Current Seminar − 2008 Future Nanobiotechnology Seminars: 2009 Archived Nanobiotechnology Seminars: 2006-07 |
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Jan 15, 2008
 Shuming Nie, Ph.D. Prof. Wallace H. Coulter Distinguished Chair Professor Biomedical Engineering Georgia Tech & Emory View Webcast 
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Nanotechnology for Cancer Molecular Imaging and Targeted Therapy: from Quantum Dots to SERS
Abstract: Nanotechnology is an interdisciplinary area of research in science, engineering, and medicine with broad applications for molecular imaging, molecular diagnosis, and targeted therapy. The basic rationale is that nanometer-sized particles such as semiconductor quantum dots (QDs) have novel optical, electronic, magnetic, and structural properties that are not available from either individual molecules or bulk solids. When linked with biotargeting or biorecognition ligands such as monoclonal antibodies, peptides, or small molecules, these nanoparticles can be used to target molecular biomarkers as well as diseased organs with high affinity and specificity. In the “mesoscopic” size range of 10-100 nm (diameter), quantum dots and polymeric nanoparticles also have more surface areas and functional groups that can be linked to multiple diagnostic (e.g., optical, radioisotopic, or magnetic) and therapeutic (e.g., anticancer) agents. Recent developments include a new class of size-minimized quantum dots for molecular and cellular imaging at the single-particle level, and a new class of nontoxic nanoparticles for in-vivo tumor targeting and spectroscopic detection based on the use of pegylated colloidal gold and surface-enhanced Raman scattering (SERS). |
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Feb 19, 2008
 Xiaoyuan (Shawn) Chen, Ph.D. Assistant Prof., Dept. of Radiology, MIPS View Webcast
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What's Next in Nanobio
Abstract: The convergence of nanotechnology and biotechnology has created and will continue to produce many excitements in the study of single molecules, biomimetics and biological nanostructure, electronic-biology interface, nanodevices for early detection of diseases, tissue engineering, molecular imaging and therapy. Despite the dazzling potential of nanobiotechnology to improve health care, there are also enormous technical hurdles for the translation of the scientific findings in the bench to the bedside. This talk will focus on the discussion of the current status and future perspective of nanotechnology in molecular imaging and therapy. |
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Mar 18, 2008
 Xiaogang Peng, Ph.D. Scharlau Professor of Chemistry Dept of Chem & Biochem Univ of Arkansas View Webcast
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Non-Cadmium Quantum Dots by Bandgap-Composition Engineering for Bio-Medical Imagining
Abstract: Semiconductor nanocrystals (quantum dots) are considered as the next generation labeling reagents for bio-medical imaging and sensing. Unfortunately, the current workhorse of quantum dots, CdSe and related materials, are so intrinsic toxic that they don’t have a real-life future. The nanocrystals without heavy metal ions, however, are with poor efficiency and poor stability. In addition, both CdSe based nanocrystals and the nanocrystals without non-heavy metal possess poor biocompatibility, including non-specific bonding, surface conjugation, and physiological permeability in biological tissue. This talk will discuss approaches to meet these challenges. |
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Apr 15, 2008
 Thomas J. Meade, Ph.D. Eileen M. Foell Prof., Dept. of Chemistry Northwestern Univ. |
The Coordination Chemistry of Molecular Probes: Its all about the Background
Abstract: Fundamental biological and clinical questions have driven technological advances in a number of diagnostic techniques. From ex-vivo DNA chip-analysis, to in vivo molecular imaging, the last decade has seen significant advances and it is clear that this trend will continue. In vivo molecular imaging has demonstrated the ability to profoundly change our understanding of these events. One technique that has been a powerful tool in both experimental and clinical settings is magnetic resonance imaging (MRI). MRI offers a non-invasive means to map structure and function by sampling the amount, flow or environment of water protons in vivo. Such intrinsic contrast can be augmented by the use of paramagnetic contrast agents in both clinical and experimental settings. It is non-invasive and yields a true volume rendering of the subject with near cellular resolution (~10 microns). Currently, the direct observation of ongoing developmental events in living embryos and the descendants of individual precursors in an intact embryo are labelled by microinjection of a stable, nontoxic, membrane impermeable MRI lineage tracers. Since a complete time-series of high-resolution three-dimensional MR images can be analyzed forward or backward in time, it is possible to reconstruct the cell divisions and cell movements responsible for any particular descendant(s). Unlike previous methods, where labelled cells are identified at the termination of the experiment, this technique allows the entire kinship relationships of a clone to be determined. In order to realize the potential of this technique a high efficient means of delivering charged MR contrast agents must be developed. In order to understand signal transduction mechanisms of gene expression in whole animals we have developed a library of molecular MR probes that are biochemically activated in-vivo. The lanthanide chelates modulate fast water exchange with the paramagnetic center, yielding distinct "strong" and "weak" relaxivity states. The modulation is triggered by two types of biological events: i. enzymatic processing of the contrast agent and, ii. the reversible binding of an intracellular messengers (e.g., Ca2+, Zn2+). |
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May 20, 2008
 Otto Zhou, Ph.D Lyles Jones Distinguished Professor of Physics and Materials Sciences View Webcast
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Carbon Nanotube X-Ray for Diagnostic Medical Imaging
Abstract: X-ray radiation is widely used today for diagnostic medical imaging, homeland security and industrial applications. Conventional x-ray source based on the original design of Roentgen and Coolidge is a single-pixel thermionic device with low spatial and temporal resolution and limited programmability, which hinders the performance of modern x-ray imaging systems. We have developed a new field emission x-ray technology based on the carbon nanotube field emitters. The new technology is capable of generating temporally and spatially modulated x-ray radiation that can be readily gated and synchronized with physiological signals. It has the potential to increase the resolution and scanning speed of today’s tomography scanners, and enable new imaging systems with new functionalities. Since the initial conception, the technology has moved from a simple laboratory curiosity to prototype production in commercial settings. In this talk we will introduce the nanotube x-ray technology. We will describe two imaging systems under development in our lab that utilize this unique x-ray technology. One is a dynamic micro-computed tomography (micro-CT) scanner for in-vivo imaging of small animal cancer models. The second is a stationary digital breast tomosynthesis system for in-vivo imaging of human breast cancer. Some other biomedical imaging and radiotherapy systems under development will be briefly described. |
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June 17, 2008
 Kannan Krishnan, Ph.D. Campbell Chair Prof., Mat'l Sci & Eng University of Washington View Webcast
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Biomedical Nanomagnetics: A Spin Through New Possibilities in Imaging, Diagnostics and Therapy
Abstract: Following a brief outlook on nanotechnology and an overview of our research, I will describe the ongoing development of nanomagnetic molecular probes (NMPs) with tailored properties, optimized for localized heating, MRI contrast enhancement and triggered drug release, and individually conjugated for specific functionality. Primary advantages of this class of NMPs are: a) the flexibility and precision with which the physical properties of the nanoparticle core -- size, size distribution, MRI relaxivity, magnetic relaxation dynamics and pH-sensitivity -- can be tailored and optimized. b) their functionality as ultrasmall and ultrasensitive MRI contrast agents with competitive performance suggesting lower dose and increased penetration. c) the optimized properties of these NMPs to generate heat locally and the therapeutic potential that this feature implies. d) their biocompatibility and very low cytotoxicity. e) their potential for translational application, primarily focused on detection and treatment of atherosclerosis and cancer. Finally, if time permits, preliminary results on the development of a magnetic particle imaging microscope -- an inexpensive, quantitative nanoimaging platform for meaningful dosimetry -- will also be presented. |
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| June 19, 2008 Clark Auditorium  Bing Xu, PhD Associate Professor, Dept. of Chemistry, Hong Kong Univ. of Sci. and Tech. View Webcast
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Design and Synthesis of Bionanomaterials for Applications from Outside to Inside of Cells
Abstract: This talk will focus on the development of two types of biofunctional nanostructures: (1) magnetic nanoparticles and (2) nanofibers formed by small therapeutic molecules. First, we will discuss the applications of magnetic nanoparticles for pathogen detections, protein separations, and intracellular manipulations. Compared to conventional used magnetic particles (with the sizes of 1-5 ?m) in biological separation or drug delivery, magnetic nanoparticles, combining with specific receptor-ligand interactions, confer high sensitivivity and selectivity for applications. Second, we will show the self-assembly of small molecules to form fibrillar nanostructures and result in hydrogels, which act as the scaffolds for potential biomedical applications such as wound healing, drug delivery, and inhibitor screening. Moreover, we will demonstrate the use of intracellular enzymatic reactions as a new way to triggers the self-assembly of hydrogelators and its potential applications for controlling the fate of cells. |
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July 15, 2008
 Kattesh Katti, M.Sc.Ed, Ph.D., FRSC Professor of Radiology and Physics University of Missouri |
Green Nanotechnology In Medicine and Technology
Abstract: Nanoparticles are used in a myriad of applications from renewable energy, medical imaging, cancer therapy, in the design of smart materials, fast computers, heat transfer agents and as environmental restoration agents. As the nanotechnology revolution continues to unfold to unleash its power on our day to day lives, the environmental impacts of various nanotechnological production processes and finished products that are embedded with a wide spectrum of nanoparticles must be addressed right at the time of inception of this emerging technology. There is spawning fundamental and mission oriented research, in both academia and industry globally, toward applications of 100% ‘Green’ nanotechnologies for the design and development of nanoparticles which in turn make their way into the design and development of smart electronic materials, life saving nanopharmaceuticals, environmental restoration technologies and in alternate green energy production devices. The sound economic models for hefty profits for the industrial corporations and their ability to perpetuate future Green nanotechnologies have created great niche for policy makers for future industrial and technological expansions. Green Nanotechnology is an interdisciplinary rapidly developing knowledge base at the interface of chemistry, physics, engineering and biological fields. Environmentally benign ‘Green’ nanotechnological processes are being developed to give the global corporate sectors the ability to design new products that are made from more eco - friendly materials including plants, crops, various phytochemicals and phytoconstructs, using processes that use less energy and generate less waste throughout the product lifecycle. This presentation will encompass description of latest discoveries from the speaker’s laboratories on the production of gold nanoparticles without the intervention of any ‘Man Made’ chemicals [1-4]. This lecture will encompass synthetic and biomedical aspects of gold nanoparticles produced via phytcohemicals, present in Soy and various plant origins. The applications of 100% ‘Green’ gold nanoparticles and green nanotechnologies in the design and development of new medical diagnostic/therapeutic agents, and biological sensors will be described. |
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Aug 19, 2008
 R. Bruce Weisman, Ph.D., Professor of Chemistry Rice University |
Near-infrared Fluorescence Imaging of Single-walled Carbon Nanotubes in Biomedicine
Abstract: TBA |
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Sept 16, 2008
 Jonathan W. Simons, M.D. Chief Executive Officer and President David H. Koch Chair Prostate Cancer Foundation |
Nanotechnologies for Personalized and Predictive Prostate Cancer Care
Abstract: TBA |
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Oct 14, 2008
 Charles Lieber, Ph.D. Mark Hyman Professor of Chemistry, Dept. of Chemistry & Chemical Biology, Harvard University |
Nanoelectronic-Biology Interfaces: From Ultrasensitive Detection to New Biomaterials
Abstract: TBA |
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Nov 13, 2008
 Chad Mirkin, Ph.D. Prof., Chemistry, Medicine, Mat'ls Science & Engineering Dir.,Intl Inst for Nanotechnology Northwestern University |
Nanostructures in Biodiagnostics and Gene Therapy
Abstract: TBA |
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Dec 16, 2008
 James Heath, Ph.D. Elizabeth W. Gilloon Professor of Chemistry, CalTech Prof., Molecular & Med Pharm, UCLA Dir., NanoSystems Biology Cancer Center, CalTech |
Systems Biology Driven Technologies for In Vitro Diagnostics of Cancer (Making Measurements Cheap)
Abstract: TBA |
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Sponsored by: Center for Cancer Nanotechnology Excellence Focused on Therapy Response (CCNE) Program - NIH/NCI U54 (MIPS); Host: Director, Sanjiv Sam Gambhir, MD, PhD (sgambhir@stanford.edu) If you would like to be included on the CCNE email distribution list for weekly meeting reminders, contact Billie Robles. |
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| Updated July 2, 2008 | |||||
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