ICMIC@Stanford

Specialized Resources

Specialized Resource 1
Chemistry/Radiochemistry Resource

Dr. Chin
Project Director

This resource is designed to help ICMIC@Stanford investigators with their needs for radiochemistry and synthetic organic chemistry. Since the design and utilization of chemistry probes is at the core of molecular imaging it is important that ICMIC@Stanford investigators have available routinely utilized PET tracers (e.g., FDG, FHBG, FIAU, FLT) as well as the ability to help investigators with custom synthesis. Support for Iodinations for PET and SPECT tracers is also provided. Furthermore, because the evolving needs of investigators may require totally new chemistry; this resource will also help researchers with synthetic organic chemistry. This resource is utilized by all four Research Projects. As more investigators start to use microPET we expect this resource will be further utilized.

Specialized Resource 2
Flow Cytometry Resource

Dr. Nolan
Principal Investigator

This resource is designed to help ICMIC@Stanford investigators with their needs in cell sorting and cell/molecular biology assays such as detection of phosphorylation events. Reporter gene strategies are critical to several of the research projects and possible future developmental projects. This facility will utilize state-of-art cytometry to allow investigators to select various cell populations as well provide quantitative assays for imaging protein phosphorylation through fluorescent antibody strategies. Furthermore Dr. Nolan's direct expertise in cell biology and phosphorylation will be very helpful for all projects. Research Projects #1-3 will significantly utilize this resource and Research Project #4 may also utilize it.

Specialized Resource 3
Small Animal Imaging Resource

Dr. Levin
Principal Investigator

This resource provides access to all the small animal imaging instruments used by all current and future ICMIC@Stanford investigators. The ability to use a multimodality imaging approach to solve a biological problem of interest with bioluminescene and fluorescence optical imaging, small animal computed tomography (microCT), micro positron emission tomography (microPET), micro single photon emission computed tomography (microSPECT), digital whole body autoradiography (DWBA), small animal high-resolution ultrasound, and small animal magnetic resonance imaging (MRI) are all key components of this resource. The ability to utilize multimodality small animal imaging instruments and to have expertise available to evolve these technologies and their uses are a key feature of this important resource. All Research Projects will utilize this resource.

Specialized Resource 4
Quantitation and Visualization Resource

Dr. Paik
Principal Investigator

This resource is designed to help ICMIC@Stanford investigators understand, quantitate, mathematically model, statistically analyze, and visualize their multimodality imaging data. We feel it is critical that molecular imaging move forward with not only the ability to obtain images but to rigorously quantitate the obtained data. This resource will help to make sure that investigators are confident in understanding and reporting the data obtained. This resource will work closely with Specialized Resource #3 and will be utilized by all Research Projects.