Center for Cancer Nanotechnology Excellence Focused on Therapy Response

Faculty

Samira Guccione, Ph.D. Investigator: Core 3 Assistant Professor of Radiology Lucas MRSI Center 1201 Welch Rd, Rm P274 Stanford, California, 94305-5488 Phone: (650) 725-4936 Fax: (650) 723-5795 Email: samira.guccione@stanford.edu

Investigator: Core 3, Assistant Professor of Radiology (Stanford)
Dr. Guccione is an Assistant Professor of Radiology at Stanford and a member of the MIPS. Her research interests include the development of imaging and therapeutic agents targeting the vasculature. She uses high throughput genomic and proteomic analysis to evaluate potential targets for imaging and therapy. Her work includes development of a nanoparticle-based molecular imaging probe that targets the integrins on the luminal side of the endothelium. These nanoparticles have been used to image tumor vasculature in models for brain (glioblastoma multiforme), melanoma, and colon metastasis to the liver and lung. A modified form of these nanoparticles has been used for gene delivery to the tumor vasculature. This anti-angiogenic therapy is being developed for clinical trials. Other areas of interest include stem cells, drug and gene delivery, radiation sensitizers, and the use of ultrasound for imaging and delivery of therapeutics.

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