Center for Cancer Nanotechnology Excellence Focused on Therapy Response

Faculty

Parag Mallick, Ph.D. Co-Investigator: Project 4 Cedars-Sinai Medical Center Louis Warschaw Prostate Cancer Center 8631 West Third Street, Suite 215E Los Angeles, CA 90048 Phone: 310-423-7600 Fax: 310-423-1998 Email: parag.mallick@cshs.org Website: http://www.doe-mbi.ucla.edu/~parag

Co-Project Leader: Project 4, Director of Clinical Proteomics (Cedars-Sinai); Assistant Professor of Chemistry and Biochemistry (UCLA)
Consultant in Proteomics for Project 6
Dr. Mallick's primary appointment is as Director of Clinical Proteomics at the Cedars-Sinai Medical Center. In addition, he is an Assistant Professor of Chemistry and Biochemistry at the University of California, Los Angeles and maintains active affiliate appointments with the Fred Hutchinson Cancer Center and Institute for Systems Biology. His unique combination of appointments enables him to catalyze synergy between several of the major institutions within this proposal. His research interests have focused on development of tools for quantitative, proteome-scale analyses of protein structure and function and on the application of those tools to global profiling for predictive, personalized cancer diagnosis and prognosis. He has historically focused on problems bridging the interface between experimental studies and analytic computational challenges. In addition, his background in genome-scale problems in computational biology has enabled him to both develop and refine tools to extract relevant information from the complex Mass Spectrometric-based serum proteome data. Towards this goal, he first used these analytic tools to complement the development of experimental procedures for serum-enrichment by identifying specific steps in the experiment that required attention. Next he applied these tools to discover and begin validation of molecular fingerprints, patterns of proteins, indicative of cancer in mouse and human models. In parallel work, he has been developing statistical models of Mass-Spectrometric processes that have enabled proteotypic peptide-array methods for high-throughput pattern discovery and validation.

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