| Education: | PhD, Biomedical Engineering, Ohio State University, 2006
BS, Physics, Mathematics and Biomedical Engineering, Tufts University, 2000 |
| Awards: | 2007 Stanford Dean's Fellowship
2006 Stanford Molecular Imaging Scholar - NIH Training Grant Post-doctoral Fellow.
National Science Foundation (NSF) Predoctoral Fellow (IGERT).
2005 - Young Investigator Travel Award - Fourth Annual Meeting of the Society for Molecular Imaging in Cologne, Germany.
2004 - Whitaker Conference Award - BioMEMS and Biomedical Nanotechnology WORLD. |
| Address: | Molecular Imaging Program at Stanford
The James H Clark Center
318 Campus Drive
East Wing, 1st Floor
Stanford, CA 94305-5427 |
| E-mail: | brsmith@stanford.edu |
| Research Interests: | I employ nanoparticulate platforms, bioconjugation, and microfabrication to
develop targeting capabilities and platforms of multifunctional diagnostic
and therapeutic devices that could be used clinically either in an in vivo
setting (e.g., molecular imaging diagnostics and/or targeted therapy) or as
part of a bedside monitoring/diagnostic device. I am interested in devising
methods to exploit the molecular basis of a variety of diseases,
particularly cancer, through the identification of molecular targets and
fusion with nanoscale platforms that can interact with standard (e.g., MRI,
PET, optical, SPECT, etc.) and non-standard (e.g., characterization mode
ultrasound) imaging techniques for diagnosis. These methods may be
realized through screening of molecular targets for imaging and/or drug
delivery and novel bioconjugation chemistries that exploit such molecules
in conjunction with materials such as carbon nanotubes, iron oxide
nanoparticles, and porous silicon (and detection modalities for these
materials). I am increasingly focusing upon translating clinically
relevant nanodevices into in vivo animal models and humans for the imaging
of therapeutic response to certain cancers. |
| Recent Publications: |
- de la Zerda A, Zavaleta C, Keren S, Vaithilingam S, Bodapati S, Liu Z, Levi J, Smith BR, Ma T, Oralkan O, Cheng Z, Chen X, Dai H, Khuri-Yakub BT, Gambhir SS. Carbon Nanotubes as Photoacoustic Molecular Imaging Agents in Living Mice. Nature Nanotechnology.2008; 3(9): 557-62.
- Smith BR, Heverhagen J, Moldovan N, Schmalbrock P, Shiomi M, Knopp MV, Lee SC. Imaging of Atherosclerotic Plaques by Molecularly Targeted Nanoparticulates (USPIOs): Proof-of-Principle with MRI. Circulation.2006; (): submitted.
- Sakamoto J, Smith BR, Xie B, Rokhlin S, Lee S, Ferrari M. The Molecular Analysis of Breast Cancer Utilizing Targeted Nanoparticulates (USPIOs): Proof-of-Principle with Ultrasound. Technology in Cancer and Research Treatment.2005; 4(6): 627-636.
- Smith BR, Heverhagen J, Knopp M, Lee S. Biologically-Targeted Superparamagnetic Nanoparticulates to Atheromatous Plaque. Molecular Imaging.2005; 4(3): 312.
- Smith BR, Nijdam AJ, Cheng MC, Liu X, Lee SC, Ferrari M. A Biological Perspective of Particulate Nanoporous Silicon. Materials Technology.2004; 19(1): 16-20.
- Sprintz M, Sakamoto J, Smith BR, Ferrari M. Opportunities in Oncological Nanotechnology. Proceedings of the 1st International Symposium on Micro and Nano Technology.2004; (): .
- Granik VT, Smith BR, Lee SC, Ferrari M. Osmotic Pressures for Binary Solutions of Non-electrolytes. Biomedical Microdevices.2002; 4(4): 309-321.
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