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Ramasamy Paulmurugan
Ramasamy Paulmurugan
Assistant Professor, Radiology, Stanford University
Member, MIPS
Education:Ph.D., Environmental Biotechnology, National Environmental Engineering Research Institute (NEERI), Nagpur, India, 1997
M.Sc., Bio-Medical Genetics, University of Madras, Madras, India, 1991
B.Sc., Zoology, Madurai Kamaraj University, Madurai, India, 1989
Awards:2006 Travel Award, Academy of Molecular Imaging for Best Paper Presentation, Orlando, Florida.

2005 Travel Award, Society of Molecular Imaging for Best Paper Presentation, Cologne, Germany.

2005 Travel Award, Academy of Molecular Imaging for Best Paper Presentation, Orlando, Florida.

2003 Travel Award, Academy of Molecular Imaging for Best Paper Presentation, San Diego, California, USA.

1999 Young Scientist Award, Government of Kerala, India.

1991 Best Project Fellow, NEERI, CSIR, Nagpur, India.
Address:Molecular Imaging Program at Stanford
Stanford University
Stanford, CA 94305
Phone:650-724-3619
Fax:650-724-4948
E-mail: paulmur8@stanford.edu
Research Interests:The main focus of this laboratory is to develop in vivo imaging strategies that can be used to study signal transduction at different stages of its network, starting from the extracellular stimulus along the path until the nucleus. Signal transduction is a regulated biochemical process by which cells convert extracellular stimuli into functional changes within the cell. This network involves many proteins, small molecule ligands and other physical agents. The intact signal transduction network plays a key role in maintaining the cells at their normal functional state. The break in the signal transduction network contributes for cells to undergo different pathological status including cancer. Currently, we are working on signal transduction imaging of estrogen receptor. Estrogen receptor is a ligand inducible transcription factor that plays an important role in the development, progression, invasiveness and response to therapy, in breast cancer. The multimodality molecular imaging approach in conjunction with the split-reporter complementation system is used to achieve this target.
Current Labs:Cellular Pathway Imaging Laboratory (CPIL)
Previous Labs:Multimodality Molecular Imaging Lab
Recent Publications:
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  • Chan CT, Paulmurugan R, ReevesRE, Solow-Cordero D, and Gambhir SS. Molecular Imaging of Phosphorylation Events for Drug Development. Molecular Imaging and Biology . 2009;11(3):144-58.

  • Chen IY, Greve JM, Gheysens O, Willmann JK, Rodriguez-Porcel M, Chu P, Sheikh AY, Faranesh AZ, Paulmurugan R, Yang PC, Wu JC, Gambhir SS. Comparison of optical bioluminescence reporter gene and superparamagnetic iron oxide MR contrast agent as cell markers for noninvasive imaging of cardiac cell transplantation. Mol Imaging Biol. 2009;11(3):178-87.

  • Chen IY, Greve JM, Gheysens O, Willmann JK, Rodriguez-Porcel M, Chu P, Sheikh AY, Faranesh AZ, Paulmurugan R, Yang PC, Wu JC, Gambhir SS.. Comparison of optical bioluminescence reporter gene and superparamagnetic iron oxide MR contrast agent as cell markers for noninvasive imaging of cardiac cell transplantation. Mol Imaging Biol.. 2009;11(3):178-87.

  • Paulmurugan R, Padmanabhan P, Ahn BC, Ray S, Willmann JK, Massoud TF, Biswal S, Gambhir SS. A novel estrogen reception intramolecular folding based titratable transgene expression system. Mol Ther. 2009;17():1703-11.

  • Ramasamy Paulmurugan, Parasuraman Padmanabhan, Byeong-Cheol Ahn, Sunetra Ray, Juergen K Willmann, Tarik F Massoud, Sandip Biswal and Sanjiv S Gambhir.. A Novel Estrogen Receptor Intramolecular Folding–based Titratable Transgene Expression System . Mol.Ther.. 2009;in press():.

  • Rodriguez-Porcel M, Gheysens O, Paulmurugan R, Chen IY, Peterson KM, Willmann JK, Wu JC, Zhu X, Lerman LO, Gambhir SS.. Antioxidants Improve Early Survival of Cardiomyoblasts After Transplantation to the Myocardium. Mol Imaging Biol. 2009;[Epub ahead of print]():.

  • Willmann JK, Paulmurugan R, Rodriguez-Porcel M, Stein W, Brinton TJ, Connolly AJ, Nielsen CH, Lutz AM, Lyons J, Ikeno F, Suzuki Y, Rosenberg J, Chen IY, Wu JC, Yeung AC, Yock P, Robbins RC, Gambhir SS. Imaging gene expression in human mesenchymal stem cells: from small to large animals. Radiology. 2009;252(1):117-27.

  • Chan, C.T., Paulmurugan, R., Gheysens, O.S., Kim J., Chiosis, G., and Gambhir, S.S. Molecular Imaging of The Efficacy of Heat Shock Protein 90 Inhibitors in Living Subjects. Cancer Research. 2008;68(1):1-11.

  • Choi CY, Chan DA, Paulmurugan R, Sutphin PD, Le QT, Koong AC, Zundel W, Gambhir SS, Giaccia AJ.. Molecular imaging of hypoxia-inducible factor 1 alpha and von Hippel-Lindau interaction in mice. Mol Imaging. 2008;7(3):139-46.

  • Paulmurugan R, Tamrazi A, Katzenellenbogen JA, Katzenellenbogen BS, Gambhir SS.. A Human Estrogen Receptor-{alpha} Mutation with Differential Responsiveness to Non-Steroidal Ligands: Novel Approaches for Studying Mechanism of ER Action.. Molecular Endocrinolofgy. 2008;Mol Endocrinol. 2008 May 1. [Epub ahead of print](July):.

  • Ray S, Paulmurugan R, Patel MR, Ahn BC, Wu L, Carey M, Gambhir SS.. Noninvasive imaging of therapeutic gene expression using a bidirectional transcriptional amplification strategy.. Mol Ther. . 2008;16(11):1848-56.

  • Seongmi Park, Deepti B. Ramnarain, Kimmo J. Hatanpaa, Bruce E. Mickey, Debabrata Saha, Ramasamy Paulmurugan, Christopher J. Madden, Paul S. Wright, Salman Bhai, M. Aktar Ali, Krishna Puttaparthi, Wei Hu, Jeffrey L. Elliott, Olaf Stuve, and Amyn A. Habib. The death domain containing kinase RIP1 regulates p27Kip 1 levels via a PI3K-Akt- Forkhead pathway.. EMBO Rep.. 2008;9(8):766-73.

  • Willmann JK, Chen K, Wang H, Paulmurugan R, Rollins M, Cai W, Wang DS, Chen IY, Gheysens O, Rodriguez-Porcel M, Chen X, Gambhir SS. Monitoring of the biological response to murine hindlimb ischemia with 64Cu-labeled vascular endothelial growth factor-121 positron emission tomography. Circulation. 2008;7(117):915-22.

  • Willmann JK, Paulmurugan R, Chen K, Gheysens O, Rodriguez-Porcel M, Lutz AM, Chen IY, Chen X, Gambhir SS. US imaging of tumor angiogenesis with microbubbles targeted to vascular endothelial growth factor receptor type 2 in mice. Radiology. 2008;246(2):508-18.

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