| Education: | Ph.D., Organic Chemistry, Purdue University, West Lafayette, IN, 2000
B.S., Chemistry, Indiana University, Bloomington, IN, 1991 |
| Awards: | 2003, 2004 NIH Fellow Award for Research Excellence
2002-2005 NIH Intramural Research Fellowship
2001-2002 Lawrence Berkeley National Laboratory Research Fellowship
1998 "Excellence in Teaching" Award IUPUI Intercollegiate Athletics Department
1998 Physical Scientist Research Award - awarded by Indiana University School of Medicine, Department of Radiology
1990 Phi Beta Kappa |
| Address: | Molecular Imaging Program at Stanford
1201 Welch Road, Rm PS049
Stanford, CA 94305-5484 |
| Phone: | (650) 725-4182 |
| Fax: | (650) 618-0415 |
| E-mail: | chinf@stanford.edu |
| Research Interests: | Our group's primary objectives are:
1) Novel radioligand and radiotracer development.
We will develop novel PET (Positron Emission Tomography) imaging agents with MIPS and Stanford faculty as well as other outside collaborations including academia and pharmaceutical industry. Although my personal research interests will be to discover and design of candidate probes that target molecular targets in the brain, our group focus will primarily be on cancer biology and gene therapy. In conjunction with our state-of-the-art imaging facility, promising candidates will be evaluated by PET imaging in small animals and primates. Successful radioligands and/or radiotracers will be extended towards future human clinical applications.
2) Designing new radiolabeling techniques and methodologies.
We will aim to design new radiolabeling techniques and methodologies that may have utility for future radiopharmaceutical development in our lab and the general radiochemistry community.
3) Radiochemistry production of routine clinical tracers.
Since we also have many interests with many Stanford faculty and outside collaborators, our efforts will also include the routine radiochemistry production of many existing radiotracers for human and non-human use. Our routine clinical tracers will be synthesized in custom-made or commercial synthetic modules (i.e. GE TRACERlab modules) housed in lead-shielded cells and be distributed manually or automatically (i.e. Comecer Dorothea) to our imagers. |
| Current Labs: | Radiochemistry Facility
|
| Recent Publications: |
- Chin FT, Subbarayan M, Berganos RA, Van de Ven SMWY, Yaghoubi SS, Gambhir SS, Quon A.. Automated Radiosynthesis of 5-[18F]Fluorouracil for Clinical PET Studies. Molecular Imaging and Biology.; In review(): .
- Liu Z, Yan Y, Chin FT, Wang F, and Chen X. Dual Integrin and Gastrin-Releasing Peptide Receptor
Targeted Tumor Imaging Using 18F-labeled PEGylated
RGD-Bombesin Heterodimer 18F-FB-PEG3-Glu-RGD-BBN
. J. Med. Chem.2009; 52(2): 425-432.
- Chin FT, Namavari M, Levi J, Subbarayan M,
Ray P, Chen X, and Gambhir SS
. Semi-automated Radiosynthesis and Biological Evaluation of [18F]FEAU: A Novel PET Imaging Agent for HSV1-tk/sr39tk
Reporter Gene Expression
. Molecular Imaging & Biology.2008; 10(2): 82-91.
- Quon A, Chang ST, Chin F, Kamaya A, Dick DW, Loo Jr BW, Gambhir SS, and Koong AC. Initial evaluation of 18F-fluorothymidine (FLT) PET/CT scanning for primary pancreatic cancer. Eur. J. Nucl. Med. Mol. Imaging.2008; 35(3): 527-31.
- Li ZB, Wu Z, Chen K, Chin FT, Chen X.. Click Chemistry for 18F-Labeling of RGD Peptides. Bioconjugate Chemistry.2007; 18(): 1987-1994.
- Rodriguez-Gomez JA, Lu J-Q, Velasco I, Rivera S, Zoghbi SS, Liow J-L, Musachio JL, Chin FT, Toyama H, Seidel J, Green MV, Thanos PK, Ichise M, Pike VW, Innis RB, and McKay RDG. Persistent dopamine functions of neurons derived from embryonic stem cells in a rodent model of Parkinsons disease. Stem Cells.2007; 25(): 918-928.
- Sprague DR, Chin FT, Liow J-S, Fujita M, Burns HD, Hargreaves R, Stubbs JB, Pike VW, Innis RB, and Mozley PD. Human Biodistribution and Radiation Dosimetry of the Tachykinin NK1 Antagonist Radioligand [18F]SPA-RQ:Comparison of Thin-Slice, Bisected, and 2-D Planar Image Analysis. Journal of Nuclear Medicine.2007; 48(1): 100-107.
- Wu Z, Li Z-B, Cai W, He L, Chin FT, Li F, Chen X.. 18F-labeled mini-PEG spacered RGD dimer (18F-FPRGD2): synthesis and microPET imaging of alpha(v)beta(3) integrin expression. Eur. J. Nucl. Med. Mol. Imaging..2007; 34(11): 1823-1831.
- Wu Z, Li Z-B, Chen K, Cai W, He L, Chin FT, Li F, Chen X. microPET Imaging of Tumor Integrin alpha(v)beta(3) Expression Using 18F-labeled PEGylated Tetrameric RGD Peptide (18F-FPRGD4). J Nucl Med.2007; 48(9): 1536-1544.
- Yasuno F, Sanabria SM, Burns HD, Hargreaves RJ, Ghose S, Ichise M, Chin FT, Morse CL, Hong J, Pike VW, and Innis RB . PET Imaging of Neurokinin-1 (NK1) Receptors with [18F]SPA-RQ in Human Subjects: Assessment of Reference Tissue Models and Their Test-Retest Reproducibility . Synapse.2007; 61(): 242-251.
- Chin FT, Morse CL, and Pike VW. Production of [18F]SPA-RQ as a PET Radioligand for Imaging Human Brain NK1 Receptors. J. of Label. Compd. Radiopharm.2006; 49(): 17-31.
- Lu SY, Hong J, Musachio JL, Chin FT, Vermeulen ES, Wikström HV, and Pike VW. Alternative methods for labeling the 5-HT1A receptor agonist, 1 [2_(4 fluorobenzoylamino)ethyl]-4-(7-methoxynaphthyl)piperazine (S14506), with carbon-11 or fluorine-18. J. of Label. Compd. Radiopharm.2005; 48(13): 971-981.
- Shetty HU, Chin FT, Musachio JL, and Pike VW. Application of an LC-MS-MS technique in the analysis of PET radiopharmaceuticals: measurement of cold-carrier in 2β-carbomethoxy-3β-(4-chlorophenyl)-8-[18F](2-fluoroethyl)nortropane, a dopamine transporter ligand. J. of Label. Compd. Radiopharm.2005; 48(13): 929-940.
- Cai L, Chin FT, Pike VW, Toyama H, Liow JS, Zoghbi S, Modell K, Briard E, Shetty U, Sinclair K, Donohue S, Tipre D, Kung MP, Dagostin C, Widdowson DA, Gao W, Herman M, Ichise M, and Innis RB. Evaluation of 18F-Labeled IMPY Derivatives as PET Radioligands for β-Amyloid in Alzheimer's Disease. J. Med. Chem..2004; 47(9): 2208-2218.
- Lu SY, Chin FT, McCarron JA, Pike VW. Improving NCA O- and N-[18F] fluoroethylation using [18F] β-fluoroethyl tosylate under microwave-enhanced conditions. J. of Label. Compd. Radiopharm.2004; 47(): 289-297.
|
view all
|
