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| Samira Guccione |
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Member, MIPS
Assistant Professor of Radiology | |
| Education: | Ph.D., Biomedical Engineering, Johns Hopkins University, 1999
M.S., Chemistry/Math, University of Virginia, Charlottesville, 1995
B.S., Chemistry/Math, University of Virginia, Charlottesville, 1988 |
| Awards: | 2003 AACR- Bristol-Myers Squibb Oncology Award
2002 ISMRM travel award
2001 AACR-AFLAC Scholar-in-training Award
2000 Certificate of Merit on poster presentation at Radiological Society of North America (RSNA)
2000 – 2002 National Cancer Institute Postdoctoral Fellowship
1995 – 1999 Whitaker Foundation Graduate Fellowship
1984 – 1988 Bachelor of Science Degree in Chemistry with Distinction
1985 – 1986 Deloach Award for outstanding student in organic chemistry
1985 – 1988 Scholarship awarded in chemistry by LaQue Center for Corrosion Technology |
| Address: | Lucas MRS Center, RM P280
1201 Welch Road
Stanford, CA 94305 |
| Phone: | 650-725-4936 |
| Fax: | 650-723-5795 |
| E-mail: | guccione@stanford.edu |
| Research Interests: | My research interests are primarily on the development of imaging and therapeutic agents targeting the vasculature.
- We use high throughput genomic and proteomic analysis to evaluate potential targets for imaging and therapy.
- We have developed a nanoparticle-based molecular imaging probe that targets the integrins (in particular alphavbeta3) on the luminal side of the endothelium.
- We have used these nanoparticles to image tumor vasculature in models for brain (glioblastoma multiforme), melanoma, and colon metastasis to the liver and lung.
- We have successfully used a modified form of these nanoparticles for gene delivery to the tumor vasculature. This approach used the dominant negative strategy to disrupt the VEGF and FGF secondary messenger pathway. This anti-angiogenic therapy is being developed for clinical trials.
- I am also interested in pro-angiogenic (re-vascularization) approaches to develop therapies for ischemic or artificial organs (Tissue engineering). Another area of interest in my lab has been the relationship of stem cells with endothelium in pathologic or inflammed tissue. This is a new area of development in my lab.
There are other smaller side projects in the lab involving drug and gene delivery, radiation sensitizers, and the use of ultrasound for imaging and delivery of therapeutics. |
| Current Labs: | Imaging and Therapeutic Platforms for Translational Medicine
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| Recent Publications: |
- D'Souza AL, Tseng JR, Butts Pauly K, Guccione S, Rosenberg J, Gambhir SS, Glazer GM. A strategy for blood biomarker amplification and localization using ultrasound. PNAS.2009; 106(40): 17152-17157.
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