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| Francis Blankenberg |
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Associate Professor of Radiology and Pediatrics, Stanford University
Member, MIPS | |
| Education: | M.D., UCLA 1986
BS, Biomedical Engineering & Materials Science, Northwestern University, 1982 |
| Awards: | 2003 The 2003 Plastic Surgery educational Foundation, Scientific Essay Committee 3rd Place Investigator Award Co-author of "Apoptosis in a Rodent Model of Cranial Suture Fusion: In situ Imaging and Gene Expression Analysis".
2003 The Journal of Nuclear Medicine's 3rd Place Award for Basic Science Investigations. Presented at the 50th Annual Meeting of the Society of Nuclear Medicine in New Orleans.
2001 Associate Professor of Pediatrics Courtesy appointment to the Department of Pediatrics; Lucile Salter Packard Children's Hospital at Stanford.
2001 Associate Professor of Radiology with Tenure Department of Radiology at Stanford University Medical Center
2000 John Caffey Award for Best Basic Science Research Paper: Detection of Early Atherosclerosis with Radiolabeled Monocyte Chemoattractant Protein-1 in Prediabetic Zucker Rats. Presented at the 43rd Annual Meeting of The Society of Pediatric Radiology, Naples Fl May 3, 2000.
1999 Fleischner Memorial Award (Chest Imaging) Paper: Evaluation of acute rejection in a model of experimental lung transplantation with 99m Tc annexin V. Presented at the Fleischner Society 29th Annual Scientific Program April 18, 1999.
1998 Assistant Professor of Pediatrics (Courtesy appointment of the Department of Pediatrics Lucile Salter Packard Children's Hospital).
1998 John Caffey Award for Outstanding Paper: Imaging acute heart and lung transplant rejection in rats by using 99mTc radiolabeled annexin V. Presented at the 41st Annual Meeting of The Society for Pediatric Radiology, Tucson, AZ, May 9, 1998.
1993 (6/16/93) Walter L. Robb Fellowship (U.C.S.F.)
1992 (06/04/92) Board Certification in Diagnostic Radiology
1985 present Alpha Omega Alpha Medical Honor Society (UCLA School of Medicine)
1985 Hortense Fishbaugh Memorial Scholarship (Affiliates of U.C.L.A.)
1983 - 1985 Eldridge Medical Scholarship
1983 - 1985 Hale Medical Scholarship
1983 - 1985 J. Clark Medical Scholarship
1981 - present Tau Beta Pi Honorary Engineering Society |
| Address: | Stanford University School of Medicine
Division of Pediatric Radiology,
Lucile Salter Packard Children's Hospital
Clinic F MC:5654
725 Welch Road
Palo Alto, CA 94304 |
| Phone: | (650) 497-8601 |
| Fax: | (650) 497-8745 |
| E-mail: | blankenb@stanford.edu |
| Research Interests: | Francis Blankenberg M.D. is supported by NCI/NIBIB RO1 EB000898-04A1 (PI-Blankenberg) 09/30/2003-7/31/2008 and NCI/NIBIB R01 CA102348-1-01 (PI-Jonathan F. Tait, CoPI-Blankenberg) 7/1/04-6/30/08. The first grant entitled, "Imaging Apoptosis In Vivo with Technetium 99m", focuses on the sensitivity and specificity of radiolabeled annexin V uptake, a marker of programmed cell death, following stroke and in tumors in response to chemotherapy in rodent and murine models, respectively. he second grant entitled, "Membrane Binding and Imaging Applications of Annexins" examining the biodistribution and imaging characteristics of a dozen mutated forms of self-chelating annexin V to better understand the in vivo binding charactersitics and mechanisms of annexin V localization in vivo. Dr. Blankenberg is also a part the NCI P50 ICMIC grant (Project 4: "Development of VEGF-driven PET imaging of tumor vasculature" Francis Blankenberg, M.D. & Joseph Backer, Ph.D.) The following specific aims are formulated to test our approach for the radiolabeling of VEGF for imaging tumor angiogenesis; Construct Cys-VEGF, a functionally active VEGF fusion protein with a cysteine-containing humanized tag, develop PET agents for rapid conjugation to a unique cysteine residue in Cys-VEGF, establish protocol for VEGF-driven PET imaging. Accomplishing these specific aims will determine the feasibility of targeted PET imaging of tumor angiogenesis in oncology patients. We expect that actively angiogenic primary cancers and metastatic lesions will be particularly amenable to VEGF-driven PET imaging. In addition, this type of imaging might provide the basis for rational selection of patients for anti-angiogenic therapies. The continuation of this project will be directed toward clinical development of VEGF-driven PET imaging. |
| Current Labs: | Nuclear Medicine Research Lab
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| Recent Publications: |
- Belhocine TZ, Blankenberg FG. 99mTc-Annexin A5 uptake and imaging to monitor chemosensitivity. Methods Mol Med.2005; 111(): 363-380.
- Ermann J, Hoffmann P, Edinger M, Dutt S, Blankenberg FG, Higgins JP, Negrin RS, Fathman CG, Strober S. Only the CD62L+ subpopulation of CD4+CD25+ regulatory T cells protects from lethal acute GVHD. Blood.2005; 105(): 2220-2226.
- Tait JF, Smith C, Blankenberg FG. Structural Requirements for In Vivo Detection of Cell Death with 99mTc-Annexin V. J Nucl Med.2005; 46(): 807-815.
- Takei T, Kuge Y, Zhao S, Sato M, Strauss HW, Blankenberg FG, Tait JF, Tamaki N. Enhanced Apoptotic Reaction Correlates with Suppressed Tumor Glucose Utilization After Cytotoxic Chemotherapy: Use of 99mTc-Annexin V, 18F-FDG, and Histologic Evaluation. J Nucl Med.2005; 46(): 794-799.
- BelhocineTZ, Tait JF, Vanderheyden J-L, Li C, Blankeneberg FG. Nuclear Medicine in the Era of Genomics and Proteomics: lessons from annexin V. Journal of Proteome Research.2004; 3(): 345-349.
- Blankenberg FG. Molecular imaging with single photon emission computed tomography. How new tracers can be employed in the nuclear medicine clinic. IEEE Eng Med Biol Mag.2004; 23(): 51-57.
- Blankenberg FG, Mandl S, Cao YA, O'Connell-Rodwell C, Contag CH, Mari C, Gaynutdinov TI, Vanderheyden JL, Backer MV, Backer JM. Tumor imaging using a standardized radiolabeled adapter protein docked to vascular endothelial growth factor. J Nucl Med.2004; 45(): 1373-1380.
- Fong KD, Song HM, Nacamuli RP, Franc BL, Mari C, Fang TD, Warren SM, Contag CH, Blankenberg FG, Longaker MT. Apoptosis in a rodent model of cranial suture fusion: in situ imaging and gene expression analysis. Plast Reconstr Surg.2004; 113(): 2037-2047.
- Mandl SJ, Mari C, Edinger M, Negrin RS, Tait JF, Contag CH, Blankenberg FG. Multi-modality Imaging Identifies Key Times for Annexin V Imaging as an Early Predictor of Therapeutic Outcome. Journal of Molecular Imaging.2004; 3(): 1-8.
- Mari C, Karabiyikoglu M, Goris ML, Tait JF, Yenari MA, Blankenberg FG. Detection of focal hypoxic-ischemic injury and neuronal stress in a rodent model of unilateral MCA occlusion/reperfusion using radiolabeled annexin V. Eur J Nucl Med Mol Imaging.2004; 31(): 733-739.
- Takei T, Kuge Y, Zhao S, Sato M, Strauss HW, Blankenberg FG, Tait JF, Tamaki N. Time Course of Apoptotic Tumor Response After a Single Dose of Chemotherapy: Comparison with 99mTc-Annexin V Uptake and Histologic Findings in an Experimental Model. J Nucl Med.2004; 45(): 2083-2087.
- Blankenberg FG. Molecular imaging: The latest generation of contrast agents and tissue characterization techniques. J Cell Biochem.2003; 90(): 443-453.
- Post AM, Katsikis PD, Tait JF, Geaghan SM, Strauss HW, Blankenberg FG. Imaging cell death with radiolabeled annexin V in an experimental model of rheumatoid arthritis. J Nucl Med.2002; 43(): 1359-1365.
- Blankenberg FG, Tait JF, Blankenberg TA, Post AM, Strauss HW. Imaging macrophages and the apoptosis of granulocytes in a rodent model of subacute and chronic abscesses with radiolabeled monocyte chemotactic peptide-1 and annexin V. Eur J Nucl Med.2001; 28(): 1384-1393.
- Narula J, Acio ER, Narula N, Samuels LE, Fyfe B, Wood D, Fitzpatrick JM, Raghunath PN, Tomaszewski JE, Kelly C, Steinmetz N, Green A, Tait JF, Leppo J, Blankenberg FG, Jain D, Strauss HW. Annexin-V imaging for noninvasive detection of cardiac allograft rejection. Nat Med.2001; 7(): 1347-52.
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