 |
|
| Christopher Contag |
|---|
Co-Director, MIPS
Associate Professor, Department of Pediatrics and of Microbiology and Immunology and, by courtesy, of Radiology | |
| Education: | Ph.D., Microbiology, University of Minnesota 1983 -1988
B.S., Biology, University of Minnesota 1981 - 1982
Iowa State University 1978 - 1981 |
| Awards: | 2005 Keynote address at CLEO - entitled "In vivo Cell Biology Using Optics"
2005 Poster of Distinction during Digestive Disease Week - entitled, "Hemin-Activated Mesothelial Cells Home To the Pancreas and Protect From Pancreatitis"
2003 one of the most cited papers in the field of engineering--ISI Article entitled "Advances in in vivo bioluminescence imaging of gene expression" as 2003 published in the journal "Annual Rev. Biomed. Eng."
1996 Cold Spring Harbor Award Imaging of Single Living Cells
1995 Upjohn Infectious Disease Prize American Federation for Clinical Research (AFCR).
1991-1994 Scholar of the American Foundation for AIDS Research (AmFAR)
1989 -1991 National Research Service Award, Postdoctoral, NIAID training grant: Molecular Basis of Host Parasite Interactions. Stanford University School of Medicine
1988 -1989 National Research Service Award; NCI Cancer Biology Training Grant University of Minnesota School of Medicine
1987-1988 Viral Research Grant, ViroMed and Minnesota Chapter of the National Foundation for Infectious Diseases
1988 Bacaner Research Award, Minnesota Medical Foundation and Basic Science Departments, University of Minnesota.
1984-1988 National Research Service Award, NCI cancer biology training grant. University of Minnesota School of Medicine. |
| Address: | Neonatal and Developmental Medicine
Department of Pediatrics
150 Clark Center
318 Campus Drive
Stanford University School of Medicine
Stanford, CA 94305-5439 |
| Phone: | (650) 725-8781 |
| Fax: | (650) 498-7723 |
| E-mail: | ccontag@stanford.edu |
| Research Interests: | The mission of our laboratory is to understand both the mechanisms of disease (cancer, infection and genetic diseases), and the complex genetic programs of mammalian development and stem cell biology. We monitor these processes noninvasively as they occur in living animals. The methods developed and used by our group can simultaneously reveal the nuances, and the overall picture of cellular and molecular processes in a living animal. Using these approaches we can rapidly assess the effects of antineoplastic therapies, antibiotics or antiviral drugs, revealing possible modes of action. These strategies result in significantly more information than can be obtained using a vivisectionist approach in that the animals are living and the data obtained in real-time. One of our scientific goals is to develop tools that make the body essentially transparent for scientific discovery, and to use these tools to understand how pathogens cause disease and how the host organism responds to these pathogens, how the immune system monitors cell transformation in cancer, and the regulatory networks that control cell migration and development. |
| Current Labs: | Molecular Biophotonics and Imaging Laboratory
|
| Recent Publications: |
- Gonzalez-Gonzalez E, Ra H, Hickerson RP, Wang Q, Leake D, Avilion AA, Solgaard O, Doyle TC, Contag CH, and Kaspar RL. SiRNA silencing of keratinocyte-specific GFP expression in a novel transgenic mouse skin model. Gene Therapy.; submitted(): .
- Hickerson RP, Vlassov AV, Wang Q, Leake D, Ilves H, Gonzalez-Gonzalez E, Contag CH, Johnston BH and Kaspar RL. Stability study and relevance to clinical use. Oligonucleotides.; submitted(): .
- Hickerson RP, Vlassov, Qian Wang, Vlasov AV, Leake D, Ilves H, Gonzalez-Gonzalez E, Contag CH, Johnston BH and Kaspar RL. Stability study of unmodified siRNA and relevance to clinical use. Oligonucleotides.; Accepted(): .
- Wang H. Trafficking Mesenchymal Stem Cell Engraftment and Differentiation in Tumor-Bearing Mice by Bioluminescence Imaging . Stem Cells.2009; (): .
- Jacobson, G.B
Shinde, R
Contag, C.H.
Zare, R.N.. Sustained Release of Drugs Dispersed in POlymer Nanoparticles. Angewandte Chemie International Edition.2008; 47(): .
- Hickerson RP, Smith FJD, Reeves RE, Contag CH, Leake D, Leachman SA, Milstone LM, McLean WHI, Kaspar RL. Single Nucleotide-Specific SiRNA Targeting in a Dominant Negative Skin Model. Journal of Investigative Dermatology.2007; (): in press.
- Smith FJD, Hickerson RP, Sayers JM, Reeves RE, Contag CH, Leake D, Kaspar RL, McLean WHI . Development of Therapeutic SiRNAs for Pachyonychia Congenita. J. Invest. Dermatol..2007; (): in press.
- Beilhack A, Schulz S, Baker J, Beilhack GF, Wieland CB, Herman EI, Baker EM, Cao YA, Contag CH, Negrin RS. In vivo analyses of early events in acute graft-versus-host disease reveal sequential infiltration of T-cell subsets. Blood.2005; 106(3): 1113-22.
- Burns-Guydish SM, Olomu IN, Zhao H, Wong RJ, Stevenson DK, Contag CH. Monitoring age-related susceptibility of young mice to oral Salmonella enterica serovar Typhimurium infection using an in vivo murine model. Pediatr Res.2005; 58(1): 153-8.
- Cao YA, Bachmann MH, Beilhack A, Yang Y, Tanaka M, Swijnenburg RJ, Reeves R, Taylor-Edwards C, Schulz S, Doyle TC, Fathman CG, Robbins RC, Herzenberg LA, Negrin RS, Contag CH. Molecular Imaging Using Labeled Donor Tissues Reveals Patterns of Engraftment, Rejection, and Survival in Transplantation. Transplantation.2005; 80(1): 134-139.
- Chatterjea D, Burns-Guydish SM, Sciuto TE, Dvorak A, Contag CH, Galli SJ. Adoptive transfer of mast cells does not enhance the impaired survival of Kit(W)/Kit(W-v) mice in a model of low dose intraperitoneal infection with bioluminescent Salmonella typhimurium. Immunol Lett.2005; 99(1): 122-9.
- Cowan CM, Aalami OO, Shi YY, Chou YF, Mari C, Thomas R, Quarto N, Nacamuli RP, Contag CH, Wu B, Longaker MT. Bone morphogenetic protein 2 and retinoic acid accelerate in vivo bone formation, osteoclast recruitment, and bone turnover. Tissue Eng.2005; 11(3-4): 645-58.
- Lin AH, Luo J, Mondshein LH, ten Dijke P, Vivien D, Contag CH, Wyss-Coray T. Global analysis of Smad2/3-dependent TGF-beta signaling in living mice reveals prominent tissue-specific responses to injury. J Immunol.2005; 175(1): 547-54.
- Tolar J, Osborn M, Bell S, McElmurry R, Xia L, Riddle M, Panoskaltsis-Mortari A, Jiang Y, McIvor RS, Contag CH, Yant SR, Kay MA, Verfaillie CM, Blazar BR. Real-time in vivo imaging of stem cells following transgenesis by transposition. Mol Ther.2005; 12(1): 42-8.
- Verneris MR, Arshi A, Edinger M, Kornacker M, Natkunam Y, Karami M, Cao YA, Marina N, Contag CH, Negrin RS. Low levels of Her2/neu expressed by Ewing's family tumor cell lines can redirect cytokine-induced killer cells. Clin Cancer Res.2005; 11(12): 4561-70.
|
view all
|
