| Education: | M.D., Ph.D., Medical Scientist Training Program, UCLA, 1993
B.S., Physics, Arizona State University, 1983 |
| Awards: | 2008 Elected to the Institute of Medicine (IOM) - Institute of Medicine of the National Academies.
2008 Tesla Medal - United Kingdom Royal College of Radiologists in England for his work in Multimodality Molecular Imaging of Living Subjects.
2008 ASCI Membership - American Society of Clinical Investigation (ASCI). The ASCI is an honor society for physician-scientists.
2006 Most Influential Radiology Researcher - AuntMinnie.com
2006 Paul C. Aebersold Award - Society of Nuclear Medicine (SNM). For contributing extensively to molecular imaging and the basic science of using radioactive tracers.
2006 Hounsfield Medal - Imperial College, London. The medal was awarded to honor contributions to the field of biomedical imaging
2005 Wagner Lectureship - Society of Nuclear Medicine (SNM). Lecture given at annual meeting to over 4,000 physicians and scientists on the future of molecular imaging.
2004 Distinguished Clinical Scientist Award - awarded by Doris Duke Charitable Foundation
2004 Achievement Award - presented by the Society of Molecular Imaging
2004 Distinguished Basic Scientist Award - presented by the Academy of Molecular Imaging
2003 Holst Medal - presented by Philips Research, Philips Medical Systems and Technical University at Eindhoven in the Netherlands. (more informatiom)
2002 Taplin Award - Western Regional Society of Nuclear Medicine. Received award for work on molecular imaging and reporter genes.
2000 Frontiers of Science Lecture - National Academy of Sciences. Invitation to speak at a meeting of the Academy for the top young scientists in the U.S. Presented work on Molecular Imaging.
1999 First Prize Scientific Exhibit - Society of Nuclear Medicine. Award given for a scientific exhibit at the 46th annual world-wide society meeting. The exhibit was on an internet based clinical trials engine for information support of distributed clinical trials.
1999 Best Scientific Paper (Basic Science) - Journal of Nuclear
Medicine. Outstanding Basic Science Investigations Award (3rd place) given for a basic science paper published in the Journal during 1998. The paper was on imaging reporter gene expression using radiolabeled
ganciclovir. |
| Address: | Molecular Imaging Program at Stanford
The James H Clark Center
318 Campus Drive
East Wing, 1st Floor
Stanford, CA 94305-5427
|
| Phone: | 650-725-2309 |
| Fax: | 650-724-4948 |
| E-mail: | sgambhir@stanford.edu |
| Research Interests: | Multimodality Molecular Imaging Assays to Interrogate Molecular/Cellular Events in Living Subjects
We are developing imaging assays to monitor fundamental cellular events in living subjects. Technologies such as micro positron emission tomography (microPET), bioluminescence optical imaging with a charge coupled-device (CCD) camera, fluorescence optical imaging, micro computerized axial tomography (microCAT) are all being actively investigated in small animal models. Our goals are to marry fundamental advances in molecular/cell biology with those in biomedical imaging to advance the field of molecular imaging. We have a particular focus on cancer biology and gene therapy. We have developed several reporter genes/reporter probes compatible with all of the above imaging modalities. These reporter genes are being used in cell trafficking models, gene therapy models, as well as in transgenic models for studying cancer biology. Assays to interrogate cells for mRNA levels, cell surface antigens, protein-protein interactions are also under active development. We are also extending many of these approaches for human clinical applications. |
| Current Labs: | Multimodality Molecular Imaging Lab
|
| Recent Publications: |
- Chin FT, Subbarayan M, Berganos RA, Van de Ven SMWY, Yaghoubi SS, Gambhir SS, Quon A.. Automated Radiosynthesis of 5-[18F]Fluorouracil for Clinical PET Studies. Molecular Imaging and Biology.; In review(): .
- Walls ZF and Gambhir SS. BRET-Based Method For Detection of Specific RNA Species. Bioconjugate Chemistry.; in press(): .
- . X. X.; (): .
- Chan CT, Paulmurugan R, ReevesRE, Solow-Cordero D, and Gambhir SS. Molecular Imaging of Phosphorylation Events for Drug Development. Molecular Imaging and Biology .2009; 11(3): 144-58.
- Chen IY, Greve JM, Gheysens O, Willmann JK, Rodriguez-Porcel M, Chu P, Sheikh AY, Faranesh AZ, Paulmurugan R, Yang PC, Wu JC, Gambhir SS. Comparison of optical bioluminescence reporter gene and superparamagnetic iron oxide MR contrast agent as cell markers for noninvasive imaging of cardiac cell transplantation. Mol Imaging Biol.2009; 11(3): 178-87.
- Cheng Z, De Jesus OP, Kramer DJ, De A, Webster JM, Gheysens O, Levi J, Namavari M, Wang S, Park JM, Zhang R, Liu H, Lee B, Syud FA, Gambhir SS. 64Cu-Labeled Affibody Molecules for Imaging of HER2 Expressing Tumors. Mol Imaging Biol.2009; Sep 25. [Epub ahead of print](): .
- Cheng Z, De Jesus OP, Kramer DJ, De A, Webster JM, Gheysens O, Levi J, Namavari M, Wang S, Park JM, Zhang R, Liu H, Lee B, Syud FA, Gambhir SS.. (64)Cu-Labeled Affibody Molecules for Imaging of HER2 Expressing Tumors. Mol Imaging Biol..2009; (): .
- D'Souza AL, Tseng JR, Butts Pauly K, Guccione S, Rosenberg J, Gambhir SS, Glazer GM. A strategy for blood biomarker amplification and localization using ultrasound. PNAS.2009; 106(40): 17152-17157.
- Gaster RS, Hall DA, Nielsen CH, Osterfeld SJ, Yu H, Mach KE, Wilson RJ, Murmann B, Liao JC, Gambhir SS, Wang SX. Matrix-insensitive protein assays push the limits of biosensors in medicine. Nature Medicine.2009; 15(11): 1327-32.
- Kimura RH, Cheng Z, Gambhir SS, Cochran JR. Engineered knottin peptides: a new class of agents for imaging integrin expression in living subjects. Cancer Res.2009; 69(6): 2435-42.
- Namavari M, Cheng Z, Zhang R, De A, Levi J, Hoerner JK, Yaghoubi SS, Syud FA, and Gambhir SS. A Novel method for Direct site-specific Radiolabeling of peptides Using [18F]FDG. Bioconjug Chem.2009; 20(): 432-436.
- Paulmurugan R, Padmanabhan P, Ahn BC, Ray S, Willmann JK, Massoud TF, Biswal S, Gambhir SS. A novel estrogen reception intramolecular folding based titratable transgene expression system. Mol Ther.2009; 17(): 1703-11.
- Ren G, Miao Z, Liu HG, Jiang L, Limpa-Amara N, Mahmood A, Gambhir SS, Cheng Z.. Melanin-Targeted Preclinical PET Imaging of Melanoma Metastasis. Journal of Nuclear Medicine.2009; 50(10): 1692-9.
- Wang H. Trafficking Mesenchymal Stem Cell Engraftment and Differentiation in Tumor-Bearing Mice by Bioluminescence Imaging . Stem Cells.2009; (): .
- Webster JM, Zhang R, Gambhir SS, Cheng Z*, Syud FA*. Engineered Two-Helix Small Proteins for Molecular Recognition. ChemBioChem.2009; 10(): 1293-1296.
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