Bioengineering/Radiology 222A
Course Syllabus

CLASSES: Monday & Friday, 9:00 - 10:50, AM Clark Center S361

Sept 25 Introduction to Molecular Imaging [ Part 1 | Part 2 ] Dr. Levin
Sept 29 Optics (physics): Tissue optics [ Download PDF - 17.3MB ]

Biomedical Photonics Handbook [ Download PDF - 7MB ]
  • Tromberg B, et al. Non-Invasive In Vivo Characterization of Breast Tumors Using Photon Migration Spectroscopy. Neoplasia 2000; 2(1-2):26-40.
    [ Download PDF - 2.1MB ]
 Dr. Contag
Oct 2 Optics (physics): 3D fluorescence imaging [ Download PDF - 12.5MBB ] Dr. Graves
Oct 6 Optics Application: Intervital Optical Neuroimaging [ Download PDF - 19.4MB ] Dr. Schnitzer
Oct 9 Optics Application: Optical Reporter Genes [ Download PDF - 5.7MB ]
  • Tsien RY. The Green Fluorescent Protein. Annu. Rev. Biochem. 1998; 67:509-44.
    [ Download PDF - 545KB ]
  • Contag C, Bachmann MH. Advances in In Vivo Bioluminescence Imaging of Gene Expression. Annu. Rev. Biomed. Eng. 2002; 4:235-60.
    [ Download PDF - 353KB ]

 Dr. Contag
Oct 13 Chemistry of Fluorescent Probes [ Download PDF - 8.3MB ]
  • Frangioni JV. In vivo near-infrared fluorescence imaging. Curr Opin Chem Biol. 2003;7(5):626-34.
    [ Download PDF - 231KB ]
  • Gao X, Yang L, Petros JA, Marshall FF, Simons JW, Nie S. In vivo molecular and cellular imaging with quantum dots. Curr Opin Biotechnol. 2005 Feb;16(1):63-72.
    [ Download PDF - 316KB ]
  • So MK, Xu C, Loening AM, Gambhir SS, Rao J. Self-illuminating quantum dot conjugates for in vivo imaging. Nature Biotechnology 2006; 24(3):339-43.
    [ Download PDF - 468KB ]
 Dr. Rao
Oct 16 MR Basic Principles [ Download PDF - 1.8MB ] Dr. McConnell
Oct 20 Molecular Imaging with MR [ Download PDF - 7.7MB ] Dr. Moseley
Oct 23 Neuroimaging by MR [ Download PDF - 19.3MB ] Dr. Moseley
Oct 27 Cardiovascular MRI/Targeted MRI Contrast Agents [ Download PDF - 6.1MB ] Dr. McConnell
Oct 30 Vascular imaging/ angiogenesis/ targeted vascular imaging [ Download PDF - 7.6 MB ] Dr. Guccione
Nov 3 Radiochemistry [ Download PDF - 3.0MB ] Dr. Chen
Nov 6 PET: Instrumentation, Methods, and Applications [ Download PDF - 17.5MB ]
Principles of Computerized Tomographic Imaging. Kak, Slaney, IEEE Press, 1988.

Physics in Nuclear Medicine. Cherry, Sorenson, Phelps, 3rd Edition. Saunders, 2003.

 Dr. Levin
November 6, 2006 - Midterm Exam

7:00 PM
Place: Learning Center (Room P083) of the Lucas Magnetic Imaging Center.
Direction: Lucas is linked to the MSLS building, at the corner of Welch Road and Pastuer Drive.
Take the outside stairs down to the first floor, and the Learning Center is at your left.

Nov 10 Multimodality Molecular Imaging of Integrin Expression [ Download PDF - 9.6MB ]
Logan J. Graphical analysis of PET data applied to reversible and irreversible tracers. Nucl Med Biol 2000;27:661-670.
[ Download PDF - 725KB ]

Cai W, Gambhir SS, Chen X. Multimodality tumor imaging targeting integrin alpha(v)beta(3). BioTechniques.2005; 39:S6-S17.
[ Download PDF - 9.2MB ]

 Dr. Chen
Nov 13 SPECT: Instrumentation, Methods and Applications [ Download PDF - 23.6MB ]
Principles of Computerized Tomographic Imaging. Kak, Slaney, IEEE Press, 1988.

Physics in Nuclear Medicine. Cherry, Sorenson, Phelps, 3rd Edition. Saunders, 2003.

 Dr. Levin
Nov 17 Imaging of Apoptosis [ Download PDF - 6.3MB ]
  1. Belhocine TZ, Tait JF, Vanderheyden JL, Li C, Blankenberg FG. Nuclear medicine in the era of genomics and proteomics: lessons from annexin V. J Proteome Res. 2004 May-Jun;3(3):345-9.
    [ Download PDF - 156KB ]
  2. Blankenberg FG. Recent advances in the imaging of programmed cell death. Curr Pharm Des. 2004;10(13):1457-67. Review.
    [ Download PDF - 296KB ]
  3. Blankenberg F, Mari C, Strauss HW. Imaging cell death in vivo. Q J Nucl Med. 2003 Dec;47(4):337-48. Review.
    [ Download PDF - 272KB ]
  4. Lahorte CM, Vanderheyden JL, Steinmetz N, Van de Wiele C, Dierckx RA, Slegers G. Apoptosis-detecting radioligands: current state of the art and future perspectives. Eur J Nucl Med Mol Imaging. 2004 Jun;31(6):887-919.
    [ Download PDF - 428KB ]
  5. Kolodgie FD, Petrov A, Virmani R, Narula N, Verjans JW, Weber DK, Hartung D, Steinmetz N, Vanderheyden JL, Vannan MA, Gold HK, Reutelingsperger CP, Hofstra L, Narula J. Targeting of apoptotic macrophages and experimental atheroma with radiolabeled annexin V: a technique with potential for noninvasive imaging of vulnerable plaque. Circulation. 2003 Dec 23;108(25):3134-9.
    [ Download PDF - 384KB ]
  6. Blankenberg FG, Strauss HW. Nuclear medicine applications in molecular imaging. J Magn Reson Imaging. 2002 Oct;16(4):352-61. Review.
    [ Download PDF - 288KB ]
Dr. Blakenberg
Nov 27 Application of Molecular Imaging in Stem Cell Therapy [ Download PDF - 1.4MB ] Dr. Wu
Dec 1 Applications of Molecular Imaging in Radiation Therapy (1) [ Download PDF - 10.6MB ] Dr. Graves
Dec 4 Applications of Molecular Imaging in Radiation Therapy (2) [ Download PDF - 1.2MB ] Dr. Xing
Dec 8 Applications of Molecular Imaging in Humans [ Download PDF - 26.5MB ] Dr. Gambhir
TBD Tour of Small Animal Imaging Facility Dr. Doyle
Monday, December 11, 2006 - Final Exam

9:00 - 11:00 AM
Place: Learning Center (Room P083) of the Lucas Magnetic Imaging Center.
Direction: Lucas is linked to the MSLS building, at the corner of Welch Road and Pastuer Drive.
Take the outside stairs down to the first floor, and the Learning Center is at your left.