Bioengineering/Radiology 222
Course Syllabus


CLASSES: Monday & Friday, 9:00 - 10:50 AM Beckman Center B-230

Sept 26 Introduction to Molecular Imaging [ Part 1 | Part 2 ] Dr. Levin
Sept 30 Optics (physics): 3D fluorescence imaging [ Download PDF - 12.5MBB ] Dr. Graves
Oct 3 Optics (physics): Tissue optics [ Download PDF - 47.7MB ]

Biomedical Photonics Handbook [ Download PDF - 7MB ]
  • Tromberg B, et al. Non-Invasive In Vivo Characterization of Breast Tumors Using Photon Migration Spectroscopy. Neoplasia 2000; 2(1-2):26-40.
    [ Download PDF - 2.1MB ]
Dr. Contag
Oct 7 Chemistry of Fluorescence [ Download PDF - 9.2MB ] Dr. Rao
Oct 10 Optics Application: Intervital Optical Neuroimaging [ Download PDF - 19.4MB ] Dr. Schnitzer
Oct 14 Optics Application: Optical Reporter Genes [ Download PDF - 26.5MB ]
  • Tsien RY. The Green Fluorescent Protein. Annu. Rev. Biochem. 1998; 67:509-44.
    [ Download PDF - 545KB ]
  • Contag C, Bachmann MH. Advances in In Vivo Bioluminescence Imaging of Gene Expression. Annu. Rev. Biomed. Eng. 2002; 4:235-60.
    [ Download PDF - 353KB ]

Dr. Contag
Oct 17 SPECT Physics [ Download PDF - 12.7MB ]
Principles of Computerized Tomographic Imaging. Kak, Slaney, IEEE Press, 1988.

Physics in Nuclear Medicine. Cherry, Sorenson, Phelps, 3rd Edition. Saunders, 2003.

Dr. Levin
Oct 21 PET Physics [ Download PDF - 9.9MB ]
Principles of Computerized Tomographic Imaging. Kak, Slaney, IEEE Press, 1988.

Physics in Nuclear Medicine. Cherry, Sorenson, Phelps, 3rd Edition. Saunders, 2003.

Dr. Levin
Oct 24 Radiochemistry [ Download PDF - 4.2MB ] Dr. Chen
Oct 28 PET Imaging of Integrin Expression [ Download PDF - 10MB ] Dr. Chen
Oct 31 Imaging of Apoptosis [ Download PDF - 7.2MB ]
  1. Belhocine TZ, Tait JF, Vanderheyden JL, Li C, Blankenberg FG. Nuclear medicine in the era of genomics and proteomics: lessons from annexin V. J Proteome Res. 2004 May-Jun;3(3):345-9.
    [ Download PDF - 156KB ]
  2. Blankenberg FG. Recent advances in the imaging of programmed cell death. Curr Pharm Des. 2004;10(13):1457-67. Review.
    [ Download PDF - 296KB ]
  3. Blankenberg F, Mari C, Strauss HW. Imaging cell death in vivo. Q J Nucl Med. 2003 Dec;47(4):337-48. Review.
    [ Download PDF - 272KB ]
  4. Lahorte CM, Vanderheyden JL, Steinmetz N, Van de Wiele C, Dierckx RA, Slegers G. Apoptosis-detecting radioligands: current state of the art and future perspectives. Eur J Nucl Med Mol Imaging. 2004 Jun;31(6):887-919.
    [ Download PDF - 428KB ]
  5. Kolodgie FD, Petrov A, Virmani R, Narula N, Verjans JW, Weber DK, Hartung D, Steinmetz N, Vanderheyden JL, Vannan MA, Gold HK, Reutelingsperger CP, Hofstra L, Narula J. Targeting of apoptotic macrophages and experimental atheroma with radiolabeled annexin V: a technique with potential for noninvasive imaging of vulnerable plaque. Circulation. 2003 Dec 23;108(25):3134-9.
    [ Download PDF - 384KB ]
  6. Blankenberg FG, Strauss HW. Nuclear medicine applications in molecular imaging. J Magn Reson Imaging. 2002 Oct;16(4):352-61. Review.
    [ Download PDF - 288KB ]
Dr. Blakenberg
Nov 4 MR Basic Principles [ Download PDF - 1.8MB ] Dr. McConnell
Nov 7 Cardiovascular MRI/Targeted MRI Contrast Agents [ Download PDF - 6.1MB ] Dr. McConnell
November 9, 2005 - Midterm Exam

3:30-5:00 PM
Place: Lucas Magnetic Imaging Center, Room P083
The exam will be open book and cover the first 11 lectures.

Nov 11 Neuroimaging by MR [ Download PDF - 15.6MB ] Dr. Moseley
Nov 14 MR for Molecular Imaging [ Download PDF - 7.1MB ] Dr. Moseley
Nov 18 Vascular development and Vascular Imaging [ Download PDF - 7.6 MB ] Dr. Guccione
Nov 28 Multi-modality Assays for Small Animal Imaging [ Part A 3.4MB, Part B 6.2MB ]
  • Massoud T, Gambhir SS. Molecular imaging in living subjects: seeing fundamental biological processes in a new light. Genes & Development 2003 17:545-580. [ Download PDF - 29.7MB ]
Dr. Wu
Dec 2 Applications of Molecular Imaging in Radiation Therapy (1) [ Download PDF - 10.6MB ] Dr. Graves
Dec 5 Applications of Molecular Imaging in Radiation Therapy (2) [ Download PDF - 1.2MB ] Dr. Xing
Dec 9 Applications of Molecular Imaging in Humans [ Download PDF - 26.5MB ] Dr. Gambhir
TBD Tour of Small Animal Imaging Facility Dr. Doyle
December 16, 2005 - Final Exam