Bioengineering/Radiology 222
Course Syllabus

CLASSES: 9:00 - 10:50 AM Beckman Center B-200B

Sept 27 Introduction to Molecular Imaging [ Part 1 | Part 2 ] Dr. Gambhir
Dr. Levin
Sept 29 Optics (physics): Tissue Optics [ Download PDF - 47.4 MB ]

Biomedical Photonics Handbook [ Download PDF - 7 MB ]
Tromberg B, et al. Non-Invasive In Vivo Characterization of Breast Tumors Using Photon Migration Spectroscopy. Neoplasia 2000; 2(1-2):26-40.
[ Download PDF - 2.1 MB ]
 Dr. Contag
Oct 4 Optics (physics): 3D Fluorescence Imaging [ Download PDF - 10.9 MB ] Dr. Graves
Oct 6 MR Basic Principles [ Download PDF - 1.8 MB ] Dr. McConnel
Oct 11 SPECT/PET Physics [ Download PDF - 21.6 MB ]
Physics in Nuclear Medicine. Cherry, Sorenson, Phelps, 3rd Edition. Saunders, 2003.

Principles of Computerized Tomographic Imaging. Kak, Slaney, IEEE Press, 1988.

 Dr. Levin
Oct 13 Chemistry of Fluorescence [ Download PDF - 9.2 MB ] Dr. Rao
Oct 18 Optics Application: Intervital Optical Neuroimaging [ Download PDF - 19.4 MB ] Dr. Schnitzer
Oct 20 Optics Application: Optical Reporter Genes
Tsien RY. The Green Fluorescent Protein. Annu. Rev. Biochem. 1998; 67:509-44.
[ Download PDF - 545 KB ]

Contag C, Bachmann MH. Advances in In Vivo Bioluminescence Imaging of Gene Expression. Annu. Rev. Biomed. Eng. 2002; 4:235-60.
[ Download PDF - 353 KB ]

 Dr. Contag
Oct 25 Digital Autoradiography Dr. Gambhir
Oct 27 Cardiovascular MRI/Targeted MRI Contrast Agents [ Download PDF - 6.1 MB ] Dr. McConnel
Nov 1 Vascular Imaging/Angiogenesis/Targeted Vascular Imaging [ Download PDF - 2.3 MB ] Dr. Guccione
Nov 3 Radiochemistry [ Download PDF - 10.8 MB ] Dr. Chen
Nov 8 Tumor Angiogenesis Imaging [ Download PDF - 30.6 MB ] Dr. Chen
Nov 10 Neuroimaging by MR [ Download PDF - 15.6 MB ] Dr. Moseley
Nov 15 MR for Molecular Imaging [ Download PDF - 7.1 MB ] Dr. Moseley
Nov 17 Imaging of Apoptosis [ Download PDF - 5.8 MB ]
  1. Belhocine TZ, Tait JF, Vanderheyden JL, Li C, Blankenberg FG. Nuclear medicine in the era of genomics and proteomics: lessons from annexin V. J Proteome Res. 2004 May-Jun;3(3):345-9.
    [ Download PDF - 156 KB ]
  2. Blankenberg FG. Recent advances in the imaging of programmed cell death. Curr Pharm Des. 2004;10(13):1457-67. Review.
    [ Download PDF - 296 KB ]
  3. Blankenberg F, Mari C, Strauss HW. Imaging cell death in vivo. Q J Nucl Med. 2003 Dec;47(4):337-48. Review.
    [ Download PDF - 272 KB ]
  4. Lahorte CM, Vanderheyden JL, Steinmetz N, Van de Wiele C, Dierckx RA, Slegers G. Apoptosis-detecting radioligands: current state of the art and future perspectives. Eur J Nucl Med Mol Imaging. 2004 Jun;31(6):887-919.
    [ Download PDF - 428 KB ]
  5. Kolodgie FD, Petrov A, Virmani R, Narula N, Verjans JW, Weber DK, Hartung D, Steinmetz N, Vanderheyden JL, Vannan MA, Gold HK, Reutelingsperger CP, Hofstra L, Narula J. Targeting of apoptotic macrophages and experimental atheroma with radiolabeled annexin V: a technique with potential for noninvasive imaging of vulnerable plaque. Circulation. 2003 Dec 23;108(25):3134-9.
    [ Download PDF - 384 KB ]
  6. Blankenberg FG, Strauss HW. Nuclear medicine applications in molecular imaging. J Magn Reson Imaging. 2002 Oct;16(4):352-61. Review.
    [ Download PDF - 288 KB ]
Dr. Blankenberg
Nov 22 Multi-modality Assays for Small Animal Imaging [ Download PDF's - Part A 29.7 MB, Part B 28.2 MB ]
Massoud T, Gambhir SS. Molecular imaging in living subjects: seeing fundamental biological processes in a new light. Genes & Development 2003 17:545-580.
Dr. Gambhir
Nov 24 Human Molecular Imaging Applications - [ Download PDF - 26.5 MB ]
Gambhir SS. Molecular Imaging of Cancer With Positron Emission Tomography. Nature Cancer 2002 2:683-693.
Dr. Gambhir
Nov 29 Applications of Molecular Imaging in Radiation Therapy (1) Dr. Xing
Dec 1 Applications of Molecular Imaging in Radiation Therapy (2) Dr. Graves
Final Exam