MIPS Molecular Imaging Program at Stanford

2015 MIPS News

Dr. Daldrup-Link Elected to the American Society for Clinical Investigation (ASCI)

Photo of Heike Daldrup-Link
March 18, 2015
Please join us in congratulating Dr. Heike Daldrup-Link in her election to the American Society for Clinical Investigation (ASCI)! She was nominated by ASCI members Dr. Sanjiv Sam Gambhir and Dr. Linda Boxer for her contributions in the field of translational cellular imaging.

Dr. Daldrup-Link introduced tumor characterizations via the enhanced permeability and retention effect and lead a first multi-center clinical trial on nanoparticle-enhanced MR imaging of breast cancer to prove this concept in patients. She discovered a new approach for MR imaging of tumor associated macrophages (TAM) with iron oxide nanoparticles in mouse models and obtained an IND to carry out the first TAM imaging trial in pediatric patients. This approach will be used in the future to monitor new anti-CD47 mAb immunotherapies in patients. In collaboration with Dr. Rao, Dr. Daldrup-Link developed tumor-enzyme activatable theranostic nanoparticles, without side effects for combined cancer imaging and therapy. She recently introduced a novel radiation-free whole body staging test for children with cancer (Lancet Oncology 2014). Dr. Daldrup-Link's cellular imaging studies also yielded several new and patented ideas for in vivo imaging of stem cell transplants, establishing immediately clinically applicable technologies for: in vivo stem cell tracking with FDA-approved nanoparticles, in vivo imaging of stem cell rejection processes with immune-cell targeted tracers, and MRI-detection of stem cell apoptosis with a caspase-activatable contrast agent. These cellular imaging tools provide a truly new way to evaluate stem cell physiology beyond simple cell detection, expanding our understanding of in vivo stem cell engraftment outcomes.

The ASCI is one of the nation's oldest and most respected medical honor societies of physician-scientists, those who translate findings in the laboratory to the advancement of clinical practice. Founded in 1908, the Society is home to more than 3,000 physician-scientists from all medical specialties elected to the Society for their outstanding records of scholarly achievement in biomedical research. The ASCI represents active physician-scientists who are at the bedside, at the research bench, and at the blackboard. Many of its senior members are widely recognized leaders in academic medicine.

The ASCI is dedicated to the advancement of research that extends our understanding and improves the treatment of human diseases, and members are committed to mentoring future generations of physician-scientists. The ASCI considers the nominations of several hundred physician-scientists submitted from among its members each year and elects up to 80 new members each year for their significant research accomplishments. Because members must be 50 years of age or younger at the time of their election, membership reflects accomplishments by its members relatively early in their careers.

Congratulations, Dr. Daldrup-Link!

MIPS Research Uses Tumor-activatable Minicircles for Early Detection of Cancer

Concept illustration of tumor-activatable minicircles
March 2, 2015

New work from the Gambhir Lab published in PNAS uses a unique strategy to force tumor cells (if they exist) to produce a blood biomarker that would otherwise not be present. This approach holds significant promise as a new way to tackle the early detection of cancer because it is not dependent on molecules that cancer cells naturally shed that enter the blood.

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Read the Stanford Announcement

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MIPS Research Featured as the Inside Cover in the Advanced Materials

Inside Cover of Advanced Materials, 2015;27(5).
February 4, 2015
The paper entitled "Perylene-Diimide-Based Nanoparticles as Highly Efficient Photoacoustic Agents for Deep Brain Tumor Imaging in Living Mice," by Quli Fan, PhD, et al. from the Cancer Molecular Imaging Chemistry Lab was highlighted by Advanced Materials as the Inside Cover.

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View the Advanced Materials Inside Cover

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