MIPS Molecular Imaging Program at Stanford

ICMIC@Stanford 2010 - 2015

Advisory Board

Executive Committee Members

Beverly Mitchell
Beverly S. Mitchell, MD
- is the Director of the Stanford Cancer Center, and the George E. Becker Professor of Medicine at Stanford University. Prior to coming to Stanford University, she was Associate Director for Translational Research at the University of North Carolina Lineberger Comprehensive Cancer Center, and Chief of the Division of Hematology/Oncology at UNC. Her research relates to the development of new therapies for hematologic malignancies. She has a long-standing interest in the enzyme IMPDH as a therapeutic target and has published extensively on the regulation of this enzyme and the potential role of inhibitors and of nucleoside analogs in the treatment of leukemia in preclinical and clinical investigations. She is also investigating the molecular pathogenesis of myelodysplastic syndromes. She also has an active ICMIC Developmental Project selected in 2008.

Robert Negrin
Robert Negrin, MD
- is Director of the Bone Marrow Transplant Program (http://bmt.stanford.edu/) at Stanford Hospital and is a Professor of Medicine. He runs an active lab focused on cell transplantation biology. He utilizes bioluminescence for cell trafficking models and understands the power of molecular imaging in studying cancer biology. He has been actively involved in helping to spread the word about molecular imaging within the Medical Center. He also has several NCI grants that utilize bioluminescence based molecular imaging and leads multiple NIH-funded programs including a program project grant as well as a T32 training grant. He is now actively using PET-CT in cancer patient management. He has also been working with Dr. Gambhir on cell imaging studies in patients using PET/SPECT.           


Norbert Pelc
Norbert Pelc, DSc
- is Associate Chair for Research and Professor of Radiology and Bioengineering with a courtesy appointment in Electrical Engineering. He has over 15 years experience in mentoring physics/engineering faculty and graduate students/postdocs. He also has significant experience in developing and managing training programs including the Program in Advanced Techniques for Cancer Imaging. Dr. Pelc also has extensive experience in the development, implementation, and evaluation of new imaging technologies, including MRI and CT, and is a recognized leader in this field.  Dr. Pelc has also served as one of 5 scientists on the President’s Advisory Council for NIH/NIBIB. He has significant interactions with the School of Engineering, Department of Applied Physics, in addition to the Department of Radiology. Dr. Pelc also co-leads the newly established strategic Center for Biomedical Imaging at Stanford (CBIS), which provides educational and networking opportunities in biomedical imaging and is providing seed funding for projects all over campus including for molecular imaging.

Internal Advisory Board Members

Scott Delp
Scott Delp, PhD
- is the former Chair of Bioengineering and the Charles Lee Powell Foundation Professor of Engineering in the Stanford School of Engineering. He has made molecular imaging a key priority for Bioengineering. His research relies heavily on MRI applications in the development of biomechanical models to analyze muscle function and study movement abnormalities. Dr. Delp also is experienced in managing NIH-funded projects. He continues to work closely with Drs. Gambhir and Pelc to strengthen bridges between Bioengineering and MIPS.

Paul Fisher
Paul G. Fisher, MD
- is Professor of Pediatrics and the Chief, Division of Child Neurology, in the Department of Neurology. His research explores the epidemiology, natural history, and disease patterns of brain tumors in childhood, as well as prospective clinical trials for treating these neoplasms. Research interests also include neurologic effects of cancer and its therapies. Dr. Fisher is board-certified by the American Boards of Pediatrics and Neuroogy, with specialty certification in neuro-oncology. He currently manages clinical trials that evaluate therapeutic radiation following surgery in children with newly diagnosed medulloblastoma and embryonal tumors as well as a study evaluating treatment of intrinsic ontine glioma. His interest in pediatric clinical trials and therapeutic response will provide critical  expertise for the continuing ICMIC@Stanford as we pursue translational goals.

Gary Glazer
Gary Glazer, MD
- is the Chair of Radiology at the Stanford School of Medicine. He has been at Stanford for over 19 years and has helped to build all aspects of Radiological Sciences in the Medical Center. He is highly supportive of molecular imaging and has mobilized significant resources to help build the MIPS. He is also highly interested in the science of Molecular Imaging, having completed a sabbatical with Dr. Markus Schwaiger (Munich) to better understand the field. Dr. Glazer is honored this year with Radiology’s highest distinction, the Radiological Society of North America (RSNA) Gold Medal Award, which is given for exemplary service to the science of Radiology. Dr. Gambhir, in his role as Head of Nuclear Medicine reports directly to Dr. Glazer.

Gary Glover
Gary Glover, PhD
- is Professor of Radiology and Head of the Radiation Sciences Lab (RSL). He, along with Drs. Norbert Pelc and Gary Glazer, helped build the RSL into a world-class MRI research center growing it from 2 faculty in 1992 to over 12 faculty and 40 staff in 2009. His expertise in MRI and building a large imaging program on the Stanford campus will be a great asset to the IAB and to the ICMIC@Stanford. He has also been very supportive of bridges between RSL and MIPS/ICMIC@Stanford, including the recent recruitment of Dr. Brian Rutt.

Richard Hoppe
Richard Hoppe, PhD
- is the Chair of Radiation Oncology at the Stanford School of Medicine. He has been actively involved in the support of molecular imaging and has invested in clinical PET/CT equipment as well as a faculty billet focused on molecular imaging. He is also coordinating efforts within his department to better link the basic science of molecular imaging with clinical applications, including development of strategies to study tumor hypoxia with molecular imaging. He helped to recruit Dr. Ted Graves as a MIPS faculty within the Department of Radiation Oncology.

Ronald Levy
Ronald Levy, MD
- is Chief, Division of Medical Oncology and a Professor of Medicine. His research interests are focused on cancer biology of lymphoma, and therapies for lymphoma. He will help to better link translational scientists as well as clinicians into the ICMIC@Stanford effort. He is actively integrating imaging into his own lab’s toolbox and encouraging its use in several clinical trials. He will help to bring medical oncology fellows interested in molecular imaging to the attention of the ICMIC@Stanford. He will also play a key role as more assays are translated into clinically useful imaging procedures for the management of cancer patients.

Albert Macovski
Albert Macovski, PhD
- is the Canon USA Professor of Electrical Engineering and Radiology (Emeritus). Dr. Macovski brings to this advisory board great distinction in virtually every area of medical imaging. He has been involved in imaging research for most of his career. Since joining the Electrical Engineering faculty at Stanford in 1976, his interests have focused on medical imaging which has included ultrasound, DSA, CT, and more recently magnetic resonance imaging. In 1985 Dr. Macovski founded the Magnetic Resonance Systems Research Lab located in the Electrical Engineering Department at Stanford, which is devoted to MRI instrumentation research. Dr. Macovski has advised over 45 doctoral students during his career.

Philip Pizzo
Philip Pizzo, MD
- is Chief, Division of Medical Oncology and a Professor of Medicine. His research interests are in focused on cancer biology of lymphoma and therapies for lymphoma. He will help to better link translational scientists as well as clinicians into the ICMIC@Stanford effort. He is actively integrating imaging into his own labs toolbox and encouraging its use in several clinical trials. He will help to bring medical oncology fellows interested in molecular imaging to he attention of the ICMIC@Stanford. He will also play a key role as more assays are translated into clinically useful imaging procedures for the management of cancer patients.

Matthew Scott
Matthew Scott, PhD
- is Professor of Developmental Biology, a Howard Hughes Medical Investigator and previous head of the Bio-X program. He is also a member of the Bio-X Scientific Leadership Council at Stanford to which Dr. Gambhir also belongs. He has been very supportive of molecular imaging and made it a top priority for the Clark Center and for the Bio-X Program. Through his direct efforts well over 10,000 square feet of lab space, including the small animal imaging resource (SR2) were made possible. His research is focused on studying evolutionarily conserved genes to learn how the growth of embryos is controlled and organized, and how birth defects and cancer arise when developmental regulatory genes malfunction. He is also an investigator in RP2 due to his expertise in models of medulloblastomas.

Branimir I. Sikic
Branimir I. Sikic, MD
- is Professor of Medicine (Oncology and Clinical Pharmacology), Associate Director of the Stanford Cancer Center, Co-Director of Stanford Center for Clinical and Translational Education and Research, and Chairman, Annual Northern California Tumor Board at Silverado, Stanford University School of Medicine. Dr. Sikic is currently conducting/recruiting for six oncology clinical trials. His interests and goals are to understand mechanisms of drug resistance in cancer cells and to develop more effective therapies. Current research ranges from biochemical and molecular studies in cellular models to Phase I, II and III clinical trials of new inhibitors of drug resistance and novel therapies. His interests in response to therapy will be of great value with this competing renewal as we focus on translating projects into the clinic.

Paul Wender
Paul Wender, PhD
- is the Bergstrom Professor of Chemistry in the Department of Chemistry, School of Humanities & Sciences. He is a member of the National Academy of Sciences. His research interests are focused on organic chemistry, medicinal chemistry, biology, and medicine. He is very interested in linking the pharmaceutical industry with molecular imaging, and in forming stronger bridges between the Department of Chemistry and the MIPS. He will be a key liaison to involving other Chemistry faculty in the MIPS and ICMIC@Stanford effort. He has helped Dr. Rao to obtain a joint appointment in Chemistry, helped us recruit several graduating chemistry students as postdoctoral fellows, and been very active with our R25T postdoctoral training grant.

External Advisory Board Members

Norbert Pelc D.Sc.
Jorge Barrio, PhD
- is Professor of Molecular & Medical Pharmacology at the UCLA School of Medicine. He has over 25 years experience in PET radiochemistry and has helped to develop many innovative PET tracers. His expertise and advice is an important part of the ICMIC@Stanford because we are continuing to expand our Chemistry/Radiochemistry Resource (SR1) and can learn from his wealth of experience over the years in running a cyclotron facility and developing PET radiopharmaceuticals. His experience with the FDA has been particularly useful over the last funding cycle, including providing advice to us to obtain an eIND for our integrin imaging PET agents.

Lee Hartwell
Lee Hartwell, PhD
- is just retiring as President and Director of the Fred Hutchinson Cancer Research Center in Seattle (Hutch), and won the 2001 Nobel Prize in Physiology or Medicine for his pioneering work in yeast genetics. His insights provided the foundation for understanding how normal cells divide and the mechanisms leading to the uncontrolled growth of cancer cells. Dr. Hartwell conducted much of his groundbreaking work at the University of Washington, where he is Professor of Genome Sciences and Adjunct Professor of Medicine. He was a critical advisor to Stanford and Dean Pizzo in our efforts to build a Comprehensive Cancer Center including a NCI Comprehensive Cancer Center grant proposal - and continues to be an incredible resource as our newly-funded Cancer Center continues to grow. He has also been directly bridging efforts in the MIPS with cancer research at the Hutch. Over the last several years, he has directly helped the MIPS to build bridges to the Canary Foundation, which has resulted in the new Canary Center for Cancer Early Detection at Stanford and new investments in space, infrastructure, and faculty for the growth of the program. As a result of his efforts to help us build bridges to the Hutch, we are a direct part of the Hutch Ovarian SPORE (N. Urban, PI) with targeted microbubble molecular imaging clinical trials. He is also a personal mentor for Dr. Gambhir to help him grow as a scientist.

Ralph Weissleder
Ralph Weissleder, MD, PhD
- is Professor of Radiology and Director of the Center for Molecular Imaging Research at Massachusetts General Hospital and Harvard Medical School. His expertise will be important because he has been leading the MGH/Harvard ICMIC P50, which has been funded since 2000. His experience and interest in developing new instruments and imaging probes has continued to be a great resource for us as we have expanded our own ICMIC. He has been of significant value to the ICMIC@Stanford with respect to optical fluorescence imaging, MR instrumentation issues, and faculty recruitment. Dr. Brian Rutt, who has collaborated with Dr. Weissleder, is now a new Radiology faculty at Stanford and is program co-leader for RP4 with Dr. J. Rao. Also, two students who have worked with the Harvard ICMIC are now postdoctoral fellows in the Stanford ICMIC. Due in large part to developing bridges between the Stanford and Harvard ICMICs, Drs. Weissleder and Gambhir (along with the University of Michigan ICMIC investigators Drs. Ross and Rehemtulla) have co-edited a new comprehensive book on Molecular Imaging (Molecular Imaging: Principles and Practice; published by PMPH USA).


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