MIPS Molecular Imaging Program at Stanford

ICMIC@Stanford 2005 - 2010

Research Projects

Research Project 1
Development and Validation of Sensors for Imaging Protein Phosphorylation in Living Subjects
Sanjiv Sam Gambhir, MD, PhD
Project Leader

The specific aims of the current research proposal are to further develop and validate a new class of imaging sensors that can report on the phosphorylation status of a protein of choice and apply them to study two specific pathways.

Research Project 2
Multi-Modality Imaging of Oncogene-Induced Tumorigenesis
Dean Felsher, MD, PhD
Project Leader

This project proposes to utilize BLI to analyze the kinetics of tumor regression upon MYC inactivation, in conjunction with microPET to analyze angiogenesis and phosphorylation state of MYC and phosphoprotein FACS analysis to examine associated changes in phosphoprotein expression. Through multi-modality imaging, we will gain insight into the mechanisms by which oncogenes initiate and sustain tumorigenesis that will serve as important clues towards the development of therapies that target oncogenes for the treatment of cancer.

Research Project 3
Dual Biotherapy for the Treatment of Malignancy
Photo of Christopher Contag
Christopher Contag, PhD
Project Leader

The objective of this project is to use advanced imaging approaches to refine this combination therapy in preclinical models and use this data to design and implement a Phase I clinical trial.

Research Project 4
PET Imaging of Brain Tumor Angiogenesis and Anti-Angiogenic Treatment
Zheng Cheng
Zhen Cheng, PhD
Project Leader

This project's objectives are to develop PET imaging techniques for brain tumor imaging in order to identify molecular structures and receptors that are altered during brain tumor growth and spread and to help predict the natural history and response to therapy. The objective in this proposal is to image brain tumor angiogenesis and anti angiogenic therapy efficacy by means of PET and MRI.

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