MIPS Molecular Imaging Program at Stanford

ICMIC@Stanford 2005 - 2010


Sanjiv Sam Gambhir, MD, PhD Sanjiv Sam Gambhir, MD, PhD
The Principal Investigator's Role

Dr. Gambhir will take on the leadership role for the ICMIC@Stanford scientific program with its goal of developing applications of multimodality molecular imaging to cancer biology. Dr. Gambhir will assume the major administrative and management role needed for the ICMIC@Stanford. All administrative staff will report to him, and he will make final approval for all administrative expenditures such as personnel assignment, major purchases, travel, etc. The ICMIC@Stanford has an Executive Committee, which will function as the major management unit for this program. Dr. Gambhir as Chair of the Executive Committee will be responsible for making final decisions related to (i) how Career Development Component trainees are selected, supervised, and evaluated (Section B.12) and (ii) how Developmental Projects are chosen, monitored, and concluded (Section B.10). Drs. Gambhir and Contag will co-chair the ICMIC@Stanford Executive Committee to ensure that Specialized Resources are allocated in an expedient and equitable manner. The Executive Committee considers interdisciplinary exchange between the ICMIC@Stanford program and other Organized Research Units (ORU's) on campus (e.g., Bio-X) to be key in establishing a successful and fully integrated program at Stanford. Dr. Gambhir will lead the effort.

Photo of Christopher Contag, PhD Christopher Contag, PhD
The Co-Principal Investigator's Role

Dr. Contag, as Co-PI will assist Dr. Gambhir in all aspects of the ICMIC@Stanford. Dr. Contag will participate in all meetings of the Executive Committee, the major decision-making body of the ICMIC@Stanford, and will chair meetings of this group in Dr. Gambhir's absence. With Dr. Gambhir, he will co-chair the meetings of the Executive Committee as they prioritize access to the Specialized Resources. Dr. Contag will join Dr. Gambhir in promoting interdisciplinary interactions between the ICMIC@Stanford program and other Organized Research Units (ORUs) on the Stanford campus; e.g., the Stanford Comprehensive Cancer Center (application to be submitted in March, 2005) and the Bio-X Program, which is home-based in the Clark Center where Drs. Contag and Gambhir have their main labs. Together, both will assure a well-managed and efficient Specialized Resource component. With Dr. Gambhir's administrative leadership roles while at UCLA, and with Dr. Contag's leadership role on the P20, both will be able to coordinate the efforts of the Specialized Resources of ICMIC@Stanford with the needs of the ICMIC@Stanford investigators fort to promote.

Francis Blankenberg M.D. Francis Blankenberg, PhD
- is an Associate Professor of Pediatric Radiology focused on pre-clinical models and clinical applications of novel SPECT and PET probes. His laboratory developed and validated 99mTc-Annexin, a SPECT probe for imaging cell death. His Developmental Project #4 (Section E) will develop new VEGF probes for PET imaging of angiogenesis He represents the part of the molecular imaging chain in which new diagnostic imaging probes must be validated in small animal models prior to their pilot testing in patients. These strategies have the potential to directly impact the monitoring of cancer patients undergoing anti-angiogenesis therapy.

Helen Blau Ph.D. Helen Blau, PhD
- is the Donald E. and Delia B. Baxter Professor, Department of Microbiology and Immunology (http://www.stanford.edu/group/blau/). Dr. Blau was chair of Molecular & Medical Pharmacology during 1997-2002 and has been the Director of Gene Therapy Technology at Stanford since 1997. Dr. Blau has significant experience in issues related to mentoring junior faculty, grant management, running a graduate training program, and is very well linked to the basic science community on campus. She has her own highly active molecular pharmacology research laboratory that has started to incorporate small animal molecular imaging.

Zhen Cheng, Ph.D. Zhen Cheng, PhD
- is an Assistant Professor in Radiology focused on PET/SPECT radiochemistry and multimodal molecular probe development. He brings to the molecular imaging research chain (Figure 1) radiochemistry expertise and a project focused on the chemistry/radiochemistry of fundamental molecular probe design. His Research Project #4 (Section C) will focus on refinement and validation of a new class of RGD peptide probes that target tumor angiogenesis. The probes developed in this project for microPET imaging of brain tumor angiogenesis in pre-clinical animal models along with his models to test angiogenesis inhibitors can be translated into a clinical setting for improved patient management.

Scott Delp Ph.D. Scott Delp Ph.D.
- is the Chair of Bioengineering and an Associate Professor of Mechanical Engineering in the Stanford School of Engineering. He has made molecular imaging a key priority for Bioengineering and has committed a new faculty billet that will bridge Bioengineering with Molecular Imaging for a search to begin in late 2004. He is working closely with Drs. Gambhir and Pelc to strengthen bridges between Bioengineering and MIPS.

Dean Felsher M.D., Ph.D. Dean Felsher, MD, PhD
- is an Assistant Professor in the Department of Medicine, Division of Oncology. He represents the new breed of translational scientists who can develop mouse models of human cancer and translate understanding of basic cancer biology into advances in therapeutics. His project on multimodality-imaging oncogene-induced tumorogenesis, Research Project #2, (Section C) (represents the mouse models component of the molecular imaging research chain (Figure 1) and is a vital component of eventually translating fundamental discoveries from bench to bedside. His use of molecular imaging in the small animal models he is developing with a focus on the c-myc oncogene should eventually help in developing and testing new therapies in mouse and in man.

Gary Glazer M.D. Gary Glazer, MD
- is the Chair of Radiology at the Stanford School of Medicine. He has been at Stanford for over 12 years and has helped to build all aspects of Radiological Sciences in the medical center. He is highly supportive of molecular imaging and has mobilized significant resources to help build the MIPS. He is also highly interested in the science of Molecular Imaging and just recently completed a 9 month sabbatical with Dr. Markus Schwaiger (Munich) to better understand the field. Dr. Gambhir, in his role as head of Nuclear Medicine reports directly to Dr. Glazer.

Gary Glover Ph.D. Gary Glover, PhD
- is Professor of Radiology and head of the Radiation Sciences Lab (RSL). He, along with Drs. Norbert Pelc and Gary Glazer, helped build the RSL into a world-class MRI research center growing it from 2 faculty in 1992 to over 12 faculty and 50 staff in 2004. His expertise in MRI and building a large imaging program on the Stanford campus will be a great asset to the IAB and to the ICMIC@Stanford.

Richard Hoppe Ph.D. Richard Hoppe, PhD
- is the Chair of Radiation Oncology at the Stanford School of Medicine. He has been actively involved in the support of Molecular Imaging and has invested in clinical PET/CT equipment as well as a faculty billet focused on molecular imaging. He is also coordinating efforts within his department to better link the basic science of molecular imaging with clinical applications, including development of strategies to study tumor hypoxia with molecular imaging.

Ron Levy M.D. Ron Levy, MD
- is Chief, Division of Medical Oncology and a Professor of Medicine. His research interests are in focused on cancer biology of lymphoma and therapies for lymphoma. He will help to better link translational scientists as well as clinicians into the ICMIC@Stanford effort. He is actively integrating imaging into his own labs toolbox and encouraging its use in several clinical trials. He will help to bring medical oncology fellows interested in molecular imaging to he attention of the ICMIC@Stanford. He will also play a key role as more assays are translated into clinically useful imaging procedures for the management of cancer patients.

Albert Macovski Ph.D. Albert Macovski, PhD
- is the Canon USA Professor of Electrical Engineering and Radiology (Emeritus). Dr. Macovski brings to this advisory board great distinction in virtually every area of medical imaging. He has been involved in imaging research for most of his career. Since joining the Electrical Engineering faculty at Stanford in 1976, his interests have focused on medical imaging which has included ultrasound, DSA, CT, and more recently magnetic resonance imaging. In 1985 Dr. Macovski founded the Magnetic Resonance Systems Research Lab located in the Electrical Engineering Department at Stanford, which is devoted to MRI instrumentation research. Dr. Macovski has advised over 45 doctoral students during his career.

Robert Negrin M.D. Robert Negrin, MD
- is director of the bone marrow transplant program (http://www-med.stanford.edu/shs/txp/bmt/) at Stanford Hospital and is an Associate Professor of Medicine. He runs an active lab focused on cell transplantation biology. He utilizes bioluminescence for cell trafficking models and understands the power of molecular imaging in studying cancer biology. He has been actively involved in helping to spread the word about molecular imaging within the medical center. He also has several NCI grants that utilize bioluminescence based molecular imaging. He is now actively using PET-CT in cancer patient management. He is also an investigator on Research Project #3 (Contag PI).

David Paik, Ph.D. David Paik, PhD
- is an Assistant Professor in Radiology interested in imaging informatics and biomedical computation. He research interests are in developing and validating informatics methods to extract information from medical images. These methods are used for image-based model creation, image segmentation, computer aided diagnosis, image quantitation and visualization. He is the PI of Specialized Resource #4 that will provide support to ICMIC@Stanford research projects and developmental projects in image quantitation, visualization and biostatistics. This Specialized Resource works especially closely with Specialized Resource #3 that provides small animal imaging to the center.

Norbert Pelc D.Sc. Norbert Pelc, DSc
- is Vice-chair and Professor of Radiology, with a courtesy appointment in Electrical Engineering. He has over 12 years experience in mentoring junior physics/engineering faculty and graduate students/post-docs. He also has significant experience in developing and managing training programs including the Program in Advanced Techniques for Cancer Imaging and the Radiological Sciences Lab (RSL) Training Program. In addition, Dr. Pelc has extensive experience in the development, implementation, and evaluation of new imaging technologies, including MRI and CT, and is a recognized leader in this field. Dr. Pelc is also one of 5 scientists on the Presidents Advisory council for the National Institutes of Biomedical and Imaging (NIBIB). He has significant interactions with the School of Engineering, Dept. of Applied Physics in addition to the Department of Radiology.

Philip Pizzo M.D. Philip Pizzo, MD
- is the Dean of the School of Medicine and along with Dr. Glazer was pivotal in the initiation of a University-wide commitment to the Molecular Imaging Program at Stanford (MIPS). We are delighted that he continues to be highly committed to the MIPS and has agreed to serve on the IAB for the ICMIC@Stanford. Dr. Gambhir, as Director of the MIPS, reports directly to Dr. Pizzo and meets with him once every 2 months on a formal basis.

Jianghong Rao Ph.D. JiangHong Rao, PhD
- is a new Assistant Professor in Radiology and Bio-X and is focused on molecular imaging research at the interface of synthetic organic chemistry and cell biology. Dr. Rao trained initially under Dr. George Whitesides in synthetic organic chemistry at Harvard and then under Roger Tsien in cell biology/pharmacology at UCSD. He represents that part of the molecular imaging research chain in which fundamental assays are developed for the field. His Developmental Project #1 (Section E) will study a new assay to image endogenous mRNA levels in living subjects utilizing fluorescence and bioluminescence optical imaging. These assays may help to better understand cancer biology and to develop and test better anti-cancer therapeutics in pre-clinical models. His chemistry expertise will also qualify him to serve as Co-PI of Specialized Resource #1 (Section D) along with Dr. Xiaoyuan (Shawn) Chen.

Mark Schnitzer Ph.D. Mark Schnitzer, PhD
- is a new Assistant Professor of Applied Physics and is also in the Bio-X. He trained in Physics at Princeton and then worked at Bell-labs prior to starting his faculty position at Stanford. He has been developing optical endoscopes to image single cells using fluorescence in intact living rodents. In Developmental Project #2 (Section E) he has teamed up with Dr. Lawrence Recht, a neuro-oncologist to study tumor cell progression in the rodent brain. He represents the important part of the molecular imaging chain in which new imaging instrumentation is developed and then pilot-tested in small animal models. This will help to better understand tumor cell biology at the cellular level with cells in their native intact environment and spur a lot of research to bridge imaging at cellular level resolution to millimeter resolution.

Matt Scott Ph.D. Matt Scott, PhD
- is Professor of Developmental Biology, a Howard Hughes Medical Investigator and head of the Bio-X program. He is also Chairman of the Bio-X Scientific Leadership Council at Stanford to which Dr. Gambhir also belongs. He has been very supportive of molecular imaging and made it a top priority for the Clark Center and for the Bio-X Program. Through his direct efforts well over 10,000 square feet of lab space, including the small animal imaging resource (Resource #3) were made possible. His research is focused on studying evolutionarily conserved genes to learn how the growth of embryos is controlled and organized and how birth defects and cancer arise when developmental regulatory genes malfunction.

Paul Wender Ph.D. Paul Wender, PhD
- is the Bergstrom Professor of Chemistry in the Department of Chemistry, School of Humanities and Sciences. His research interests are focused on organic chemistry and medicinal chemistry. He is very interested in linking the pharmaceutical industry with Molecular Imaging and in forming stronger bridges between the Department of Chemistry and the MIPS. He will be a key liaison to involving other Chemistry faculty in the MIPS and ICMIC@Stanford effort.


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