MIPS Molecular Imaging Program at Stanford

Research Scientists

Carmel Chan, PhD

Carmel Chan, PhD

Research Scientist, Multimodality Molecular Imaging Lab (MMIL)

Education:

Ph.D. City of Hope Graduate School of Biological Sciences, 2004
B.Sc. (Honors) University of British Columbia, Vancouver, Canada, 1998

Awards:

2010 Travel Award - ARCMP Joint Symposium for Catholic Univ. of Korea - MIPS Stanford University, Seoul, South Korea

2010 Travel award - 5th International Conference on 'The Hsp90 Chaperone Machine' in Les Diablerets, Switzerland

2009 Junior Scientist Travel Award -Institute of Molecular Imaging Sciences/Academy of Molecular Imaging for World Molecular Imaging Congress, Montreal.

2008 Student Travel Award -World Molecular Imaging Congress.

2006-2008 Postdoctoral Fellowship Award - Susan G. Komen Breast Cancer Foundation. Project title "Imaging the efficacy of Heat Shock Protein 90 Inhibitors in Human Breast Cancers".

2005 Young Investigator Travel Award - Academy of Molecular Imaging

2005 Travel Award - American Association of Cancer Research Edward A. Smuckler Memorial Pathobiology of Cancer Workshop

2000-2004 Trainee Award, Department of Defense Breast Cancer Research Training Program at City of Hope National Medical Center & Beckman Research Institute

2001-2004 Predoctoral Fellowship Award, Department of Defense Breast Cancer Research Program

2000 Young Investigator Award, for American Association of Cancer Research Conference on 'Signal transduction in Cancer'.

1994-95 Dean's Honors List, University of California, Davis


Contact Information:

James Clark Center E150
Department of Radiology
Stanford University School of Medicine
318 Campus Drive
Stanford, CA-94305

Phone: 650-724-3624
Fax: 650-724-4948
E-mail: carmelc@stanford.edu


Research Interests:

signal transduction, drug resistance, molecular imaging of biological events


Recent Publications:

  1. Chan CT, Reeves RE, Geller R, Yaghoubi SS, Solow-Cordero D, Paulmurugan R and Gambhir SS. Discovery and Validation of a Novel Class of Heat Shock Protein 90 (Hsp90) Inhibitors through Multi-modality Molecular Imaging of Chaperone Interactions in Living Subjects. Proceedings of the National Academy of Science Plus. In Press.
  2. James ML, Shen B, Zavaleta CL, Nielsen CH, Mesangeau C, Vuppala PK, Chan CT, Avery BA, Fishback JA, Matsumoto RR, Gambhir SS, McCurdy CR, and Chin FT. A new Positron Emission Tomography (PET) radioligand for imaging Sigma-1 receptors in living subjects. J. Med. Chem. In Press.
  3. Van de Ven S, Elias SG, Chan CT, Miao Z, Cheng Z, De A, and Gambhir SS. (2012). Optical Imaging with Her2-Targeted Affibody Molecules Can Monitor Hsp90 Treatment Response in a Breast Cancer Xenograft Mouse Model. Clin Cancer Res 18:1073-1081.
  4. Dragulescu-Andrasi A, Chan, C.T., De A and Gambhir SS. Enhanced Bioluminescence Resonance Energy Transfer Strategies for Imaging of Protein-Protein Interactions in Deep Tissues of Living Subject. Accepted by Proceedings of the National Academy of Sciences 2011.
  5. Gheysens O, Chen IY, Rodriguez-Porcel M, Chan C.T., Rasooly J, Vaerenberg C, Paulmurugan R, Willmann JK, Deroose C, Wu J, Gambhir SS. Non-invasive Bioluminescence Imaging of Myoblast-Mediated Hypoxia-Inducible Factor-1 alpha Gene Transfer. Mol Imaging Biol. 2011.
  6. Fan-Minogue H, Z Cao, Paulmurugan R, Chan CT, Massoud TF, Felsher DW, Felsher DW, Gambhir SS. Noninvasive molecular imaging of c-Myc activation in living mice. Proceedings of the National Academy of Sciences 2010;107(36):15892-15897.
  7. Chan CT, Paulmurugan R, Reeves RE, Solow-Cordero D, and Gambhir SS. Molecular Imaging of Phosphorylation Events for Drug Development. Mol Imaging Biol. 2009;11(3):144-158.
  8. Chan CT and Gambhir SS. (2008). Encyclopedia of Diagnostic Imaging. Baert (Ed.) Springer, Berlin New York Heidelberg.
  9. Chan CT, Paulmurugan R, Gheysens OS, Kim J, Chiosis G, and Gambhir SS. Molecular Imaging of The Efficacy of Heat Shock Protein 90 Inhibitors in Living Subjects. Cancer Research. 2008;68(1):1-11.
  10. Levi J, Cheng Z, Gheysens O, Patel M, Chan CT, Wang Y, Namavari M, Gambhir SS. Fluorescent fructose derivatives for imaging breast cancer cells. Bioconjug Chem. 2007;18(3):628-34.
  11. Chan CT, Metz MZ, Kane SE. Differential sensitivities of trastuzumab (Herceptin®)-resistant human breast cancer cells to phosphoinositide-3 kinase (PI-3K) and epidermal growth factor receptor (EGFR) kinase inhibitors. Breast Cancer Research and Treatment. 2005;9(2):187-201.
  12. Paulmurugan R, Ray P, De A, Chan CT, Gambhir SS. Imaging protein-protein interactions in living subjects. Trends in Analytical Chemistry. 2005;24(5):446-458.
  13. Paulmurugan R, Ray P, De A, Chan CT, Gambhir SS. Imaging protein-protein interactions in living animals. Protein-Protein Interactions. Chapter 35. 2005;():695-714.
  14. Kyle AH, Chan CT, Minchinton AI. Characterization of three-dimensional tissue cultures using electrical impedance spectroscopy. Biophysical Journal. 1999;76(5):2640-2648.

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