MIPS Molecular Imaging Program at Stanford

Research Scientists

Bryan Smith, PhD

Bryan Smith, PhD

Senior Research Scientist, Multimodality Molecular Imaging Lab


PhD, Biomedical Engineering, Ohio State University, 2006
BS, Physics, Mathematics and Biomedical Engineering, Tufts University, 2000


2007 Stanford Dean's Fellowship

2006 Stanford Molecular Imaging Scholar - NIH Training Grant Post-doctoral Fellow.

National Science Foundation (NSF) Predoctoral Fellow (IGERT).

2005 - Young Investigator Travel Award - Fourth Annual Meeting of the Society for Molecular Imaging in Cologne, Germany.

2004 - Whitaker Conference Award - BioMEMS and Biomedical Nanotechnology WORLD.

Contact Information:

Molecular Imaging Program at Stanford
The James H Clark Center
318 Campus Drive
East Wing, 1st Floor
Stanford, CA 94305-5427

Research Interests:

I employ nanoparticulate platforms, bioconjugation, and microfabrication to develop targeting capabilities and platforms of multifunctional diagnostic and therapeutic devices that could be used clinically either in an in vivo setting (e.g., molecular imaging diagnostics and/or targeted therapy) or as part of a bedside monitoring/diagnostic device. I am interested in devising methods to exploit the molecular basis of a variety of diseases, particularly cancer, through the identification of molecular targets and fusion with nanoscale platforms that can interact with standard (e.g., MRI, PET, optical, SPECT, etc.) and non-standard (e.g., characterization mode ultrasound) imaging techniques for diagnosis. These methods may be realized through screening of molecular targets for imaging and/or drug delivery and novel bioconjugation chemistries that exploit such molecules in conjunction with materials such as carbon nanotubes, iron oxide nanoparticles, and porous silicon (and detection modalities for these materials). I am increasingly focusing upon translating clinically relevant nanodevices into in vivo animal models and humans for the imaging of therapeutic response to certain cancers.

Recent Publications:

  1. Li Z, Wilson KD, Smith B, Kraft D, Jia F, Huang M, Xie X, Robbins RC, Gambhir SS, Weissman IL, Wu JC. Transcriptional and functional profiling of human embryonic stem cell-derived endothelial cells for treatment of myocardial infarction. PLoS ONE. 2009;4(12):e8443.
  2. Zavaleta CL, Smith BR, Walton I, Doering W, Davis G, Shojaei B, Natan MJ, Gambhir SS. Multiplexed imaging of surface enhanced Raman scattering nanotags in living mice using noninvasive Raman spectroscopy. PNAS. 2009;106(32):13511-13516.
  3. de la Zerda A, Bodapati S, Teed R, Schipper ML, Keren S, Smith BR, Ng JST, Gambhir SS. A Comparison Between Time Domain and Spectral Imaging Systems for Imaging Quantum Dots in Small Living Animals. Molecular Imaging and Biology. 2009.
  4. Smith BR, Cheng Z, De A, Koh AL, Sinclair R, Gambhir SS. Real-Time Intravital Imaging of RGD−Quantum Dot Binding to Luminal Endothelium in Mouse Tumor Neovasculature. Nano Letters. 2008;8(9):2599–2606.
  5. de la Zerda A, Zavaleta C, Keren S, Vaithilingam S, Bodapati S, Liu Z, Levi J, Smith BR, Ma T, Oralkan O, Cheng Z, Chen X, Dai H, Khuri-Yakub BT, Gambhir SS. Carbon Nanotubes as Photoacoustic Molecular Imaging Agents in Living Mice. Nature Nanotechnology. 2008;3(9):557-62.
  6. Smith BR, Heverhagen J, Moldovan N, Schmalbrock P, Shiomi M, Knopp MV, Lee SC. Imaging of Atherosclerotic Plaques by Molecularly Targeted Nanoparticulates (USPIOs): Proof-of-Principle with MRI. Circulation. 2006.
  7. Sakamoto J, Smith BR, Xie B, Rokhlin S, Lee S, Ferrari M. The Molecular Analysis of Breast Cancer Utilizing Targeted Nanoparticulates (USPIOs): Proof-of-Principle with Ultrasound. Technology in Cancer and Research Treatment. 2005;4(6):627-636.
  8. Smith BR, Heverhagen J, Knopp M, Lee S. Biologically-Targeted Superparamagnetic Nanoparticulates to Atheromatous Plaque. Molecular Imaging. 2005;4(3):312.
  9. Smith BR, Nijdam AJ, Cheng MC, Liu X, Lee SC, Ferrari M. A Biological Perspective of Particulate Nanoporous Silicon. Materials Technology. 2004;19(1):16-20.
  10. Sprintz M, Sakamoto J, Smith BR, Ferrari M. Opportunities in Oncological Nanotechnology. Proceedings of the 1st International Symposium on Micro and Nano Technology. 2004.
  11. Granik VT, Smith BR, Lee SC, Ferrari M. Osmotic Pressures for Binary Solutions of Non-electrolytes. Biomedical Microdevices. 2002;4(4):309-321.

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