Education:

PhD, McGill University, 1991
MSc, University of British Columbia, 1986
BSc, Brock University, 1984

Awards:

1992-1995 Canadian Heart and Stroke Foundation Post-doctoral research fellowship (McMaster University)
1989 First prize at Ninth Annual Student Research Seminar (McGill University)
1984-1986 Canadian Medical Research Council Graduate Scholarship (UBC)

Contact Information:

Research Interests:

Early detection of cancer, integrin tracers, use of tracers to follow therapy, Stem Cells, Impact of Aging, Telomere and Telomerase Biology

Recent Publications:

1. Chang E., Roldan,J.C., Kelantan M., Deisinger M., Detsch D. , Reichert T.E., Gurtner G.C. Quantifying migration and polarization of human mesenchymal stem cells on different bone substitutes by confocal laser microscopy. Clincal and Oral Implants Res.. 2010;In Press:.
2. Chin F.T., Shen B., Liu S., Berganos R.A., CHANG E., Mittra E., Chen X.Y., Gambhir S.S.. First Experience with Clinical-grade [18F]FPP(RGD)2: An Automated Multi-step Radiosynthesis for Clinical PET Studies. Jour Nucl Med. 2010;submitted.
3. Roldán J.C, Chang E., Kelantan M., Detsch R., Schlüfter, S., Deisinger U., Waiss, W., Reichert, T.E., Gurtner G. . Bone formation and degradation of a novel calcium phosphate ceramic in presence of BMP, VEGF and mesenchymal stem cells in an ectopic mouse model. Clinical and Oral Implants. 2010;In Press.
4. Thangarajah H, Vial I, Chang E, El-Ftesi S, Januszyk M, Chang EI, Paterno J, Neofytou E, Longaker MT, Gurtner GC. Adipose Stromal Cells Adopt a Proangiogenic Phenotype Under the Influence of Hypoxia. Stem Cells. 2009;27:266-274.
5. Chang E., Gurtner G.C.. "Priming" Endothelial Progenitor Cells: A New Strategy to Improve Cell Based Therapeutics. ATVB. 2008;28:1034-1035.
6. Chang E., Matsushita, H., Glassford A.J., Cooke J.P., Chiu C.P. and Tsao P.S.. eNOS activity is reduced in senescent human endothelial cells: Preservation by hTERT Immortalization. Circ. Res.. 2002;89:793-798.
7. CHANG E, Yang J, , Cherry AM, Bangs CD, Oei Y, Bodnar A, Bronstein A, Chiu CP, Herron GS, . Human endothelial cell life extension by telomerase expression. J Biol.Chem. 1999;274(37):26141-26148.
8. Jiang XR, CHANG E, Jimenez G, Frolkis M, Kusler B, Sage M, Beeche M, Bodnar AG, Wahl GM, Tlsty TD, Chiu CP, . Telomerase expression in human somatic cells does not induce changes associated with a transformed phenotype. Nature Genetics. 1999;1:111-114.
9. CHANG E. and Harley,C.B.. Telomere length as a biomarker in human vascular tissues. Proc. Natl. Acad. Sci. USA. 1995;92:11190-11194.
10. Feng J., Funk W.D., Wang S.S., Weinrich S.L., Avilion A.A., Chiu C.P., Adams R.R., CHANG E., Allsopp R.C., Yu J., Le S., West M.D., Harley C.B., Andrews W.H., Greider C.W. and Villeponteau B.. The RNA component of human telomerase. Science. 1995;269:1236-1241.