MIPS Molecular Imaging Program at Stanford

Postdoctoral Fellows

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Kyeongsoon Park, PhD

Postdoctoral Scholar, Cardiovascular Gene and Cell Therapy Laboratory (CGCT)

Education:

Ph.D, Materials Science and Engineering, Gwangju Institute of Science and Technology, Korea, 2006


Contact Information:

Stanford University School of Medicine Grant Building S114 Stanford, CA 94305


Research Interests:

Molecular imaging for cancer and inflammatory diseases, Nanomedicine and theragnostics, Stem cell therapy and tissue regenerative medicine


Recent Publications:

  1. Lee S, Rhu JH, Park K, Lee A, Lee SY, Youn IC, Ahn CH, Yoon SM, Myung SJ, Moon DH, Chen X, Choi K, Kwon IC, Kim K . Self-Assembled Polymeric Activatable Nanosensor for Protease Determination In Vivo. Nano Letters . 2009.
  2. Lee SJ, Park K, Oh YK, Kwon SH, Her S, Kim IS, Choi K, Lee SJ, Kim H, Lee SG, Kim K, Kwon IC. Tumor specificity and therapeutic efficacy of photosensitizer-encapsulated glycol chitosan-based nanoparticles in tumor-bearing mice. Biomaterials. 2009;30:2929-2939.
  3. Park JS, Park K, Moon HT, Woo DG, Yang HN, Park KH. Electrical pulsed stimulation of surfaces homogeneously coated with gold-nanoparticles to induce neurite outgrowth of PC12 cells. Langmuir. 2009;25:451-457.
  4. Park K, Lee S, Kang E, Kim K, Choi K, Kwon IC. New generation of multifunctional nanoparticles for cancer imaging and therapy. Advanced Functional Materials . 2009;19:1553-1566.
  5. Choi KY, Lee S, Park K, Kim K, Park JH, Kwon IC, Jeong SY. Preparation and characterization of Hyaluronic Acid-based hydrogel nanoparticles. Journal of Physics and Chemistry of Solid. 2008;69:1591-1595.
  6. Kim D, Lee ES, Park K, Kwon IC, Bae YH. Doxorubicin loaded pH-sensitive micelle: antitumoral efficacy against ovarian A2780/DOXR tumor. Pharmaceutical Research. 2008;25:2074-2082.
  7. Kim JH, Kim YS, Park K, Kang E, Lee S, Nam HY, Kim K, Park JH, Chi DY, Park RW, Kim IS, Choi K, Kwon IC. Self-assembled glycol chitosan nanoparticles for the sustained and prolonged delivery of antiangiogenic small peptide drugs in cancer therapy. Biomaterials. 2008;29:1920-1930.
  8. Kim JH, Kim YS, Park K, Lee S, Nam HY, Min KH, Jo HG, Park JH, Choi K, Jeong SY, Park RW, Kim IS, Kim K, Kwon IC. Antitumor Efficacy of Cisplatin-loaded Glycol Chitosan Nanoparticles in Tumor-Bearing Mice. Journal of Controlled Release. 2008;127:41-49.
  9. Kwon SM, Nam HY, Nam T, Park K, Lee S, Kim K, Kwon IC, Kim J, Kang DM, Park JH, Jeong SY. In vivo time-dependent gene expression of cationic lipid-based emulsion as a stable and biocompatible non-viral gene carrier. Journal of Controlled Release. 2008;128:89-97.
  10. Lee DY, Park K, Kim SY, Park RW, Kim IS, Kwon IC, Kim SY, Byun Y . Antimetastatic effect of an orally active heparin derivative on experimentally induced metastasis. Clinical Cancer Research. 2008;14:2841-2849.
  11. Lee ES, Gao Z, Kim D, Park K, Kwon IC, Bae YH. Super pH-sensitive multifunctional polymeric micelle for tumor pHe specific TAT exposure and multidrug resistance. Journal of Controlled Release. 2008;129:228-236.
  12. Lee S*, Park K*, Lee SY, Ryu JH, Park JW, Ahn HJ, Kwon IC, Youn IC, Kim K, Choi K . Dark Quenched Fluorogenic Probe for Osteoarthritis Imaging In Vivo. Bioconjugate Chemistry. 2008;19:1743-1747 (co-first author).
  13. Lee S, Cha EJ, Park K, Lee SY, Hong JK, Sun IC, Kim SY, Choi K, Kwon IC, Kim K, Ahn CH. A Near-Infrared Fluorescence-Quenched Gold Nanoparticle Imaging Probe for Drug Screening and Cancer Diagnosis. Angewandte Chemie International Edition. 2008;47:2804-2807.
  14. Lee S, Park K, Kim K, Choi K, Kwon IC. Activatable imaging probes with amplified fluorescent signals. Chemical Communications. 2008;36:4250-4260.
  15. Min KH*, Park K*, Kim YS, Bae SM, Lee S, Jo HG, Park RW, Kim IS, Jeong SY, Kim K, Kwon IC . Hydrophobically modified glycol chitosan nanoparticles-encapsulated camptothecin enhance the drug stability and tumor-targeting in cancer therapy. Journal of Controlled Release. 2008;127:208-218 (co-first author).
  16. Na SJ, Chae SY, Lee S, Park K, Kim K, Park JH, Kwon IC, Jeong SY, Lee KC. Stability and bioactivity of nanocomplex of TNF-related apoptosis-inducing ligand. International Journal of Pharmaceutics. 2008;363:149-154.
  17. Park JH, Lee S, Kim JH, Park K, Kim K, Kwon IC. Polymeric nanomedicine for cancer therapy. Progress in Polymer Science. 2008;33:113-137.
  18. Park JS*, Park K*, Woo DG, Yang HN, Chung HM, Park KH. Triple Constructs Consisting of Nanoparticles and Microspheres for Bone-Marrow-Derived Stromal-Cell-Delivery Microscaffolds. Small. 2008;4(11):1950-1955.
  19. Park JS, Park K, Woo DG, Yang HN, Chung HM, Park KH. PLGA microsphere construct coated with TGF-beta3 loaded nanoparticles for neocartilage formation.. Biomacromolecules. 2008;9:2162-2169 .
  20. Park K, Hong HY, Moon HJ, Lee BH, Kim IS, Kwon IC, Rhee K. A new atherosclerotic lesion probe based on hydrophobically modified chitosan nanoparticles functionalized by the atherosclerotic plaque targeted peptides. Journal of Controlled Release. 2008;128:217-223.
  21. Park K, Kim YS, Lee GY, Park RW, Kim IS, Kim SY, Byun Y. Targeting of RGD-modified heparin derivative to tumor endothelium: Inhibition of angiogenesis and tumor growth. Pharmaceutical Research. 2008;25(12):2786-2798.
  22. Park K, Lee GY, Park RW, Kim IS, Kim SY, Byun Y. Combination therapy of heparin-deoxycholic acid conjugate and doxorubicin against squamous cell carcinoma and B16F10 melanoma. Pharmaceutical Research. 2008;25:268-276.
  23. Park K, Park JS, Na K, Woo DG, Sun K, Chung HM, Park KH. The use of chondrogenic differentiation drugs to induce stem cell differentiation using double bead microsphere structure. Biomaterials. 2008;29:2490-2500.
  24. Kim JH, Lee S, Park K, Nam HY, Jang SY, Youn I, Kim K, Jeon H, Park RW, Kim IS, Choi K, Kwon IC. Protein phosphorylation-responsive polymeric nanoparticles for imaging protein kinase activities in single cells. Angewandte Chemie International Edition. 2007;46:5779-5782 .
  25. Kim JH, Park K, Lee S, Nam HY, Park JH, Kim K, Kwon IC. Biopolymers for molecular imaging. Progress in Polymer Science. 2007;32:1031-1053.
  26. Ko J*, Park K*, Kim YS, Kim MS, Han JK, Kim K, Park RW, Kim IS, Song HK, Lee DS, Kwon IC. Tumoral acidic extracellular pH targeting of pH-responsive MPEG-poly(beta-amino ester) block copolymer micelles for cancer therapy. Journal of Controlled Release. 2007;123:109-115 (co-first author).
  27. Lee GY, Park K, Kim SY, Byun Y. MMPs-specific PEGylated peptide-DOX conjugate micelles that can contain free doxorubicin. European Journal of Pharmaceutics and Biopharmaceutics. 2007;67:646-654.
  28. Na K, Kim S, Park K, Kim K, Woo DG, Kwon IC, Chung HM, Park KH. A heparin/poly(L-lysine) nanoparticle-coated polymeric microspheres for stem cell therapy. Journal of American Chemical Society. 2007;129:5788-5789.
  29. Park K, Kim JH, Nam YS, Lee S, Nam HY, Kim K, Park JH, Kim IS, Choi K, Kim SY, Kwon IC . Effect of polymer molecular weight on the tumor targeting characteristics of self-assembled glycol chitosan nanoparticles. Journal of Controlled Release. 2007;122:305-314.
  30. Park K, Kim YS, Lee GY, Nam JO, Lee SK, Park RW, Kim SY, Kim IS, Byun Y. Antiangiogenic effect of bile acid acylated heparin derivative. Pharmaceutical Research. 2007;24:176-185.
  31. Park K, Lee SK, Son DH, Park SA, Kim K, Chang HW, Jeong EJ, Park RW, Kim IS, Kwon IC, Byun Y, Kim SY. The attenuation of experimental lung metastasis by a bile acid acylated-heparin derivative. Biomaterials. 2007;28:2667-2676.
  32. Yu MK, Lee DY, Kim YS, Park K, Park SA, Son DH, Lee GY, Nam JH, Kim SY, Kim IS, Park RW, Byun Y. Antiangiogenic and apoptotic properties of a novel amphiphilic folate-heparin-lithocholate derivative having cellular internality for cancer therapy. Pharmaceutical Research. 2007;24:705-714.
  33. Choi Y, Kim SY, Park K, Yang JH, Cho KJ, Kwon HJ, Byun Y. Chemopreventive efficacy of all-trans-retinoic acid in biodegradable microspheres against epithelial cancers: Results in a 4-nitroquinoline 1-oxide-induced oral carcinogenesis model. International Journal of Pharmaceutics. 2006;320:45-52.
  34. Lee GY, Park K, Kim SY, Byun Y. Anti-tumor and anti-metastatic effects of gelatin-doxorubicin and PEGylated gelatin-doxorubicin nanoparticles in SCC7 bearing mice. Journal of Drug Targeting. 2006;14:707-716.
  35. Lee GY, Song JH, Kim SY, Park K, Byun Y. Peptide-doxorubicin conjugates specifically degraded by matrix metalloproteinases expressed from tumor. Drug Development Research. 2006;67:438-447.
  36. Park K, Lee GY, Kim YS, Yu MK, Park RW, Kim IS, Kim SY, Byun Y. Heparin-deoxycholic acid chemical conjugate as an anti-cancer drug carrier and its anti-tumor activity. Journal of Controlled Release. 2006;114:300-306.
  37. Kim SK, Kim K, Lee S, Park K, Park JH, Kwon IC, Byun Y. Evaluation of absorption of heparin-DOCA conjugates on the intestinal wall using a surface plasmon resonance. Journal of Pharmaceutical and Biomedical Analysis. 2005;39:861-870.
  38. Lee S, Kim SK, Lee DY, Park K, Kumar TS, Chae SY, Byun Y. Cationic analogue of deoxycholate as an oral delivery carrier for ceftriaxone. Journal of Pharmaceutical Sciences. 2005;94:2541-2548.
  39. Park K, Yang JH, Choi Y, Lee C, Kim SY, Byun Y. Chemoprevention of 4-NQO-induced oral carcinogenesis by co-administration of all-trans retinoic acid loaded microspheres and celecoxib. Journal of Controlled Release. 2005;104:167-179.
  40. Park K, Choi Y, Kim SY, Byun Y. Augmentation of all-trans-retinoic acid concentration in plasma by preventing inflammation responses induced by atRA-loaded microspheres with concurrent treatment of dexamethasone. Drug Development Research. 2004;61:197-206.
  41. Park K, Kim K, Kwon IC, Kim SK, Lee S, Lee DY, Byun Y. Preparation and characterization of self-assembled nanoparticles of heparin-deoxycholic acid conjugates. Langmuir. 2004;20:11726-11731.
  42. Park K, Yu MK, Byun Y. Heparin nanoparticles having anti-tumor effects. The Polymer Society of Korea. 2004;15:422-429.
  43. Choi Y, Kim SY, Kim SH, Yang JH, Park K, Byun Y . Inhibition of tumor growth by biodegradable microspheres containing all-trans-retinoic acid loaded biodegradable microspheres in rats. International Journal of Cancer. 2003;107:145-148.
  44. Choi Y, Lee C, Park K, Kim SH, Han S, Kim SY, Byun Y. Subcutaneous toxicity of all-trans-retinoic acid loaded biodegradable microspheres in rats. Drug Development Research. 2003;59:326-332.

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