2012 MIPS Molecular Imaging Seminar Series

Calendars and Scheduling

Use the links below to view event calendars and the availability and schedules of rooms.

Seminar 5:30 − 6:15 pm
Discussion 6:15 − 6:30 pm
Reception 6:30 − 7:00 pm
Li Ka Shing Center, Rm. LK130
Stanford University Campus
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Current Molecular Imaging Seminar - 2012
Archived Molecular Imaging Seminars
2011 | 2010 | 2009 | 2008 | 2007 | 2006 | 2005 | 2003-2004

Invited Speakers
January 5, 2012 February 2, 2012 March 1, 2012 April 5, 2012 May 3, 2012 October 4, 2012 November 1, 2012 December 6, 2012	Zheng-Rong Lu, PhD - View Webcast Jianwei John Miao, PhD - View Webcast Lidia Sambucetti, PhD - View Webcast Otto Zhou, PhD Paolo Decuzzi, PhD Peter Caravan, PhD Dennis Hallahan, MD Steve Conolly

Jan 5, 2012 Zheng-Rong Lu, PhD M. Frank and Margaret Domiter Rudy Professor Biomedical Engineering Dept. Case Western Reserve University View Webcast	Novel Contrast Agents for MR Molecular Imaging of Tumor Microenvironment Abstract: Tumor microenvironment plays a critical role in cancer survival, angiogenesis, proliferation and metastasis. Molecular imaging of biomarkers in tumor microenvironment provides accurate characterization of tumor angiogenesis, earlier detection and diagnosis of malignant tumors and non-invasive evaluation of anticancer therapeutics efficacy. We have designed and developed polydisulfide-based biodegradable macromolecular MRI contrast agents for evaluating tumor angiogenesis and targeted nanoglobular MRI contrast agents for detecting a cancer-related biomarker expressed in the extracellular matrix of malignant tumors. The biodegradable macromolecular contrast agents are effective for characterizing tumor angiogenesis and non-invasive evaluation of tumor response to cancer therapies in DCE-MRI. The targeted contrast agents specifically bind to the biomarker in tumor extracellular matrix, resulting in strong and prolonged contrast enhancement in the tumor tissue, not in normal tissues. The novel MRI contrast agents have shown a potential for accurate characterization of tumor angiogenesis, timely evaluation of anticancer therapeutic efficacy and specific cancer molecular imaging with MRI.
Feb 2, 2012 Munzer Jianwei John Miao, PhD Prof, Physics and Astronomy CNSI, UCLA View Webcast	Lensless X-ray Microscopy and Low-Dose X-ray Phase Contrast Tomography Abstract For centuries, lens-based microscopy, such as light, phase-contrast, fluorescence, confocal and electron microscopy, has played an important role in the evolution of modern sciences and technologies. In 1999, a novel form of microscopy, i.e. coherent diffraction microscopy (also denoted coherent diffraction imaging or lensless imaging) was developed and transformed our traditional view of microscopy, in which the physical lenses are replaced with a Fourier-based iterative algorithm. In this talk, I will briefly discuss the principle of lensless X-ray microscopy and present some biological and biomedical applications. In the second part of my talk, I will show that this Fourier-based iterative algorithm can be combined with a novel data acquisition scheme to form equally sloped tomography (EST). Using the European Synchrotron Radiation Facility in France, several tilt series of phase-contrast X-ray images were measured from a human breast cancer sample. Our reconstruction results indicated that EST with 512 projections visually produced a 3D image with comparable or better image quality than conventional tomography with 2000 projections. In addition, EST 512 and FBP 2000 reconstructions were blindly evaluated by six independent radiologists. They unanimously confirmed that the EST 512 reconstruction is superior to the FBP 2000 reconstruction. The Mean Glandular Dose (MGD) was estimated to be 2.3 mGy for the EST 512 reconstruction, which is less than the average dose in a dual-view screening routine exam.
Mar 1, 2012 Munzer Lidia Sambucetti, PhD Sr Dir, Center for Cancer Research View Webcast	Molecular Imaging Applications for Drug Discovery; from Animals to Single Cells Abstract Molecular Imaging technologies that have been applied to various aspects of cancer drug discovery will be discussed. Examples of imaging applications in target validation, screening, compound optimization and companion diagnostics will be described along with their impact on the development of novel cancer therapeutics.
Apr 5, 2012 LK130 Otto Zhou, PhD David Godschalk Distinguished Professor UNC, Chapel Hill	Carbon Nanotube X-Ray Technology forDigital Breast Tomosynthesis and Microbeam Radiation Therapy Abstract We recently developed a new x-ray source technology utilizing the carbon nanotubes (CNTs) as the electron field emitters. This distributed x-ray source array technology with flexible source configuration and digital control of radiation opens up new possibilities for designing x-ray tomography scanners with enhanced resolution and scanning speed, and for developing novel radiotherapy systems. Several imaging and radiation therapy systems are currently at difference stages of development. A stationary digital tomosynthesis scanner for detection of human breast tumor has been demonstrated which offers a higher spatial resolution, a faster scanning speed, and potentially a higher sensitivity for micro-calcification compared to the current rotating-gantry tomosynthesis scanners. We have also initiated an effort on microbeam radiotherapy, which is an experimental andpreclinical technique that has been shown in synchrotron based animal studies to be effective for eradication of brain tumor while sparing normal tissue. In this talk we will provide an update on the status of the CNT x-ray source technology and will introduce the stationary digital breast tomosynthesis and microbeam radiation therapy systems currently under development at UNC.
May 3, 2012 LK130 Paolo Decuzzi, PhD Dept. of Transl Imag & Dept. of Nanomed The Methodist Hospital Res Inst	Rational Design of Multifunctional Nanoconstructs for Biomedical Imaging and Cancer Therapy Abstract Nanoconstructs are multifunctional, particle-based devices for the ‘smart’ delivery of therapeutic and imaging agents. In this lecture, first, an integrated approach will be presented for the rational design of nanoconstructs with high level of accumulation within the diseased tissue and minimal sequestration by the organs of the reticulo-endothelial system (liver, spleen, kidneys, lungs). Second, a new class of multifunctional nanoconstructs will be described offering superior contrast enhancement for MR imaging and thermal ablation potential under non invasive electromagnetic fields. The integrated approach for the rational design of nanoconstructs combines together the in-silico mathematical modeling for the vascular transport and adhesion of blood-borne nanoparticles, in-vitro microfluidic-based assays and in-vivo intravital microscopy analysis in small animals. The multifunctional nanoconstructs are based on mesoporous silicon and hydrogel-based particles exhibiting a variety of size and shape combinations, loaded with Gd-based contrast agents (Magnevist®; Gd-nanotubes and Gd-fullerenes) for T1-based MRI and SuperParamagnetic iron oxide (SPIOs) for T2-based MRI. In the presence of non-invasive electromagnetic fields, these nanoconstructs could also generate thermal toxicity for tissue ablation and/or triggered drug release.
Oct 4, 2012 Clark Peter Caravan, PhD Assist Prof., Radiology Harvard Medical School	Title TBD Abstract
Nov 1, 2012 Clark Dennis Hallahan, MD Elizabeth H. and James S. McDonnell, III Distinguished Professor Head, Rad Onc Washington University School of Medicine Mallinckrodt Institute of Radiology	Imaging the Biodistribution and Pharmacokinetics of Nanoparticles and Antibodies Targeted to Cancer Abstract
Dec 6, 2012 Clark Steve Conolly Prof, Bioeng & EE & Computer Sci UC Berkeley	Title TBD Abstract
Sponsored by: Molecular Imaging Program at Stanford (MIPS) (mips.stanford.edu); Host: Director, Sanjiv Sam Gambhir, MD, PhD (sgambhir@stanford.edu) Current Seminar - 2012 Archived Molecular Seminar Series - 2011 \| 2010 \| 2009 \| 2008 \| 2007 \| 2006 \| 2005 \| 2003-2004 If you would like to be included on the MIPS email distribution list for weekly meeting reminders, contact Susan Singh.